Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 24, 2023

Knowledge of aging biology needs to be expanded due the continuously growing number elderly people worldwide. Aging induces changes that affect all systems body. The risk cardiovascular disease and cancer increases with age. In particular, age-induced adaptation immune system causes a greater susceptibility infections contributes inability control pathogen growth immune-mediated tissue damage. Since impact on function, is still fully elucidated, this review addresses some recent understanding age-related affecting key components immunity. emphasis immunosenescence inflammaging are impacted by common infectious diseases characterized high mortality, includes COVID-19, HIV tuberculosis.

Language: Английский

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A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?

Aging Cell, Journal Year: 2022, Volume and Issue: 21(9)

Published: Aug. 24, 2022

Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against the microbiota, well conduit for signaling between microbiota systemic host immunity. As individuals age, balance these systems undergoes myriad of changes due to age-associated IECs themselves, immunosenescence, inflammaging. In this review, we discuss emerging data related loss intestinal integrity posit that IEC dysfunction may play central role in propagating alterations composition immune homeostasis.

Language: Английский

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Short-chain fatty acids improve inflamm-aging and acute lung injury in old mice

AJP Lung Cellular and Molecular Physiology, Journal Year: 2023, Volume and Issue: 324(4), P. L480 - L492

Published: Feb. 21, 2023

A chronic proinflammatory milieu (inflamm-aging) is observed in the elderly and associated with poorer prognosis acute lung injury (ALI). Gut microbiome-derived short-chain fatty acids (SCFAs) are known to have immunomodulatory capabilities, but their function gut-lung axis aging poorly understood. Here, we analyzed gut microbiome its impact on inflammatory signaling tested effects of SCFAs young (3 mo) old (18 mice that received either drinking water a mixture each 50 mM acetate, butyrate, propionate for 2 wk or alone. ALI was induced by intranasal lipopolysaccharide (LPS; n = 12/group) administration. Controls ( 8/group) saline. Fecal pellets were sampled analysis before after LPS/saline treatment. The left lobe collected stereology right lobes cytokine gene expression analysis, cell activation, proteomics. Different microbial taxa, such as Bifidobacterium, Faecalibaculum, Lactobacillus correlated positively pulmonary inflammation aging, suggesting an inflamm-aging axis. supplementation reduced inflamm-aging, oxidative stress, metabolic alteration, enhanced activation myeloid cells lungs mice. also SCFA In summary, study provides new evidence play beneficial role organism reducing ameliorating severity

Language: Английский

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The contribution of age-related changes in the gut-brain axis to neurological disorders

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 18, 2024

Trillions of microbes live symbiotically in the host, specifically mucosal tissues such as gut. Recent advances metagenomics and metabolomics have revealed that gut microbiota plays a critical role regulation host immunity metabolism, communicating through bidirectional interactions microbiota-gut-brain axis (MGBA). The regulates both systemic contributes to neurodevelopment behaviors host. With aging, composition changes, emerging studies linked these shifts microbial populations age-related neurological diseases (NDs). Preclinical demonstrated microbiota-targeted therapies can improve behavioral outcomes by modulating microbial, metabolomic, immunological profiles. In this review, we discuss pathways brain-to-gut or gut-to-brain signaling summarize metabolites across lifespan disease. We highlight recent investigating 1) changes with aging; 2) how aging maternal microbiome affect offspring health; 3) contribution chronic (e.g., Parkinson's disease, Alzheimer's disease cerebral amyloidosis), acute brain injury, including ischemic stroke traumatic injury.

Language: Английский

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Intestinal Permeability, Gut Inflammation, and Gut Immune System Response Are Linked to Aging-Related Changes in Gut Microbiota Composition: A Study in Female Mice

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(4)

Published: Feb. 14, 2024

Aging entails changes at the cellular level that increase risk of various pathologies. An association between gut microbiota and age-related diseases has also been attributed. This study aims to analyze in fecal composition their with genes related immune response, inflammation, intestinal barrier impairment. Fecal samples female mice different ages (2 months, 6 12 18 months) gene expression colon tissue were analyzed. Results showed older group had a more diverse than younger group. Additionally, abundance Cyanobacteria, Proteobacteria, Flavobacteriaceae, Bacteroides, Parabacteroides, Prevotellaceae_UCG-001, Akkermansia, Parabacteroides goldsteinii increased age. In contrast, there was notable decline Clostridiaceae, Lactobacillaceae, Monoglobaceae, Ligilactobacillus, Limosilactobacillus, Mucispirillum, Bacteroides faecichinchillae. These bacteria imbalances positively correlated inflammation markers colon, including Tnf-α, Ccl2, Ccl12, negatively tight junction (Jam2, Tjp1, Tjp2), as well response (Cd4, Cd72, Tlr7, Tlr12, Lbp). conclusion, high levels diversity did not result improved health mice; however, imbalance occurs aging might contribute senescence, leaky disease.

Language: Английский

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Effects of In Vitro Fermented Pleurotus eryngii on Intestinal Barrier Integrity and Immunomodulation in a Lipopolysaccharide-Induced Colonic Model

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 430 - 430

Published: Feb. 11, 2025

Background: This study investigates the impact of fermentation supernatants (FSs) from Pleurotus eryngii whole mushrooms (PEWS), as well its subcomponents, digested (PEWSD) and extracted (PEWSE) forms, on intestinal barrier function immune modulation in lipopolysaccharide (LPS) -stimulated Caco-2 cells. Methods: Gene expression tight junction (TJs) genes, cytokines, key immune/metabolic receptors was assessed via qRT-PCR, while cytokine protein levels were measured using ELISA to explore post-transcriptional regulation. Results: LPS challenge significantly downregulated TJs zonula occludens-1 (ZO-1,) occludin, claudin-1, compromising epithelial integrity. Treatment with FS-PEWS notably restored ZO-1 occludin expression, outperforming FS-PEWSD FS-PEWSE, which only partially mitigated LPS-induced damage. further demonstrated potent immunomodulatory effects, upregulating anti-inflammatory IL-10 pro-inflammatory cytokines such IL-8 TNF-α. The activation like TLR-2 mTOR suggests that modulates critical metabolic pathways, NF-kB signaling, maintain homeostasis. Although mRNA altered, no corresponding release detected, suggesting potential Conclusions: preserves integrity responses, particularly low-grade inflammation, highlighting food matrix’s role enhancing bioactivity functional potential.

Language: Английский

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Cistanche deserticola polysaccharides alleviate cognitive decline in aging model mice by restoring the gut microbiota-brain axis

Aging, Journal Year: 2021, Volume and Issue: 13(11), P. 15320 - 15335

Published: June 3, 2021

Recent evidence suggests alterations in the gut microbiota-brain axis may drive cognitive impairment with aging. In present study, we observed that prolonged administration of D-galactose to mice induced decline, microbial dysbiosis, peripheral inflammation, and oxidative stress. this model age-related Cistanche deserticola polysaccharides (CDPS) improved function D-galactose-treated by restoring homeostasis, thereby reducing stress inflammation. The beneficial effects CDPS these aging were abolished through ablation microbiota antibiotics or immunosuppression cyclophosphamide. Serum metabolomic profiling showed levels creatinine, valine, L-methionine, o-Toluidine, N-ethylaniline, uric acid proline all altered mice, but restored CDPS. These findings demonstrated improves a D-galactose-induced homeostasis axis, which alleviated an amino imbalance, thus shows therapeutic potential for patients memory learning disorders, especially those related dysbiosis.

Language: Английский

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Gut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine

Clinical Interventions in Aging, Journal Year: 2023, Volume and Issue: Volume 18, P. 963 - 986

Published: June 1, 2023

Abstract: The changing composition of gut microbiota, much like aging, accompanies people throughout their lives, and the inextricable relationship between both has recently attracted extensive attention as well. Modern medical research revealed that a series changes in microbiota are involved aging process organisms, which may be because modulates aging-related related to innate immunity cognitive function. At present, there is no definite effective method delay aging. However, Nobel laureate Tu Youyou’s on artemisinin inspired researchers study importance Traditional Chinese Medicine (TCM). TCM, an ancient alternative medicine, unique advantages preventive health care treating diseases it already formed independent understanding system. TCM practitioners believe mechanism mainly deficiency, pathological states such blood stasis, qi stagnation phlegm coagulation can exacerbate involves organs, including brain, kidney, heart, liver spleen. Our current led us realise indeed make some beneficial changes, improvement impairment. due multi-component multi-target nature exploration its action become extremely complex. While analysing this review explores similarities differences treatment methods mechanisms Medicine, order explore new approach combines regulate improve Keywords: traditional microbiota-gut-brain axis

Language: Английский

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Airborne Exposure to Pollutants and Mental Health: A Review with Implications for United States Veterans

Current Environmental Health Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 168 - 183

Published: March 8, 2024

Language: Английский

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The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review

Aging Cell, Journal Year: 2024, Volume and Issue: 23(10)

Published: Aug. 15, 2024

Abstract The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, predisposition age‐associated diseases. Cellular senescence, characterized by cessation of cell division response various stressors, induces morphological functional changes within tissues. complexity heterogeneity senescent cells, alongside secretion senescence‐associated secretory phenotype, exacerbate process through pro‐inflammatory pathways influence microenvironment immune system. Concurrently, aging‐associated diversity composition contribute dysbiosis, further exacerbating inflammation undermining integrity bodily functions. This review encapsulates burgeoning research on reciprocal relationship highlighting their collective impact age‐related musculoskeletal diseases, including osteoporosis, sarcopenia, osteoarthritis. It also explores potential modulating targeting innovative strategies healthy mitigating progression aging‐related conditions. By exploring targeted interventions, development senotherapeutic drugs probiotic therapies, this aims shed light novel therapeutic avenues. These leverage connection advance interventions aimed at extending health span improving quality life older population.

Language: Английский

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