Evidence for reduced choroid plexus volume in the aged brain DOI Creative Commons

R Youh,

Charith Perera, Ian F. Harrison

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Background The choroid plexus plays an important role in brain homeostasis, including the active secretion of cerebrospinal fluid. Its function and structure have been reported to be affected by normal ageing. However, existing measures volume may complicated partial ( vivo MRI) tissue fixation artefacts (histology). In this study, we investigate possible changes within lateral ventricles aged mice utilising two structural MRI protocols explicitly designed for time-efficient, high-resolution imaging plexus. Methods Two sequences were utilised examine young (∼6 months) (∼24 mouse brains: 1) ultra-long echo-time T2 weighted fast-spin-echo 2) a multi-TE T2* mapping protocol. A test-retest study was performed on subset data reproducibility estimation. two-way ANOVA test determine differences groups across distinct protocols. Results Reproducibility tests showed low variability manual segmentation pipeline both statistically significant reduction found brain. This finding is concordant with previous histology studies that observed epithelial cell height ageing wide range species. Conclusions We present investigation ventricle approach based bespoke time-efficient high resolution Furthermore, these protocols, provide evidence research provides insight measurements as biomarker age-related neurologic conditions it indicates process itself does not result hypertrophy plexus, but decrease volume.

Language: Английский

Chronic Active Lesions and Larger Choroid Plexus Explain Cognition and Fatigue in Multiple Sclerosis DOI Creative Commons
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani

et al.

Neurology Neuroimmunology & Neuroinflammation, Journal Year: 2024, Volume and Issue: 11(2)

Published: Feb. 13, 2024

Chronic inflammation may contribute to cognitive dysfunction and fatigue in patients with multiple sclerosis (MS). Paramagnetic rim lesions (PRLs) choroid plexus (CP) enlargement have been proposed as markers of chronic MS being associated a more severe disease course. However, their relation impairment has not fully explored yet. Here, we investigated the contribution PRL number volume CP MS.

Language: Английский

Citations

21
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan DOI Creative Commons
Jarrod Eisma, Colin D. McKnight, Kilian Hett

et al.

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 29, 2024

Abstract Background The choroid plexus functions as the blood-cerebrospinal fluid (CSF) barrier, plays an important role in CSF production and circulation, has gained increased attention light of recent elucidation circulation dysfunction neurodegenerative conditions. However, methods for routinely quantifying volume are suboptimal require technical improvements validation. Here, we propose three deep learning models that can segment from commonly-acquired anatomical MRI data report performance metrics changes across adult lifespan. Methods Fully convolutional neural networks were trained 3D T 1 -weighted, 2 2D -weighted FLAIR using gold-standard manual segmentations control participants lifespan (n = 50; age 21–85 years). Dice coefficients, 95% Hausdorff distances, area-under-curve (AUCs) calculated each model compared to FreeSurfer two-tailed Wilcoxon tests (significance criteria: p < 0.05 after false discovery rate multiple comparisons correction). Metrics regressed against lateral ventricular generalized linear assess varying levels atrophy. Finally, applied expanded cohort controls 98; 21–89 years) provide exemplar volumetry values Results Deep results yielded coefficient 0.72, distance 1.97 mm, AUC 0.87 MRI, 2.22 0.74, 1.69 MRI; did not differ significantly between sequences statistically improved current commercially-available algorithms (p 0.001). intraclass coefficients 0.95, 0.96 FLAIR, models, respectively. Mean ventricle all was 3.20 ± 1.4 cm 3 ; a significant, positive relationship (R 0.54-0.60) observed participant Conclusions Findings support comparable delineation standard, clinically available, non-contrasted sequences. software embedding evaluated is freely available online should useful tool growing number studies desire quantitatively evaluate structure function ( https://github.com/hettk/chp_seg ).

Language: Английский

Citations

14
Choroid plexus volume as a marker of retinal atrophy in relapsing remitting multiple sclerosis DOI
Muhammad Faraz Raghib,

Fen Bao,

Mahmoud Elkhooly

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 457, P. 122884 - 122884

Published: Jan. 17, 2024

Language: Английский

Citations

7
Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients DOI Creative Commons
Samuel Klistorner, Michael Barnett, Chenyu Wang

et al.

Multiple Sclerosis Journal, Journal Year: 2024, Volume and Issue: 30(4-5), P. 496 - 504

Published: Feb. 6, 2024

Background and Objective: We explored dynamic changes in the choroid plexus (CP) patients with relapsing-remitting multiple sclerosis (RRMS) assessed its relationship chronic lesion expansion atrophy various brain compartments. Methods: Fifty-seven RRMS were annually for a minimum of 48 months 3D FLAIR, pre- post-contrast T1 diffusion-weighted magnetic resonance imaging (MRI). The CP was manually segmented at baseline last follow-up. Results: volume significantly increased by 1.4% annually. However, extent enlargement varied considerably among individuals (ranging from −3.6 to 150.8 mm 3 or −0.2% 6.3%). magnitude correlated central ( r = 0.70, p < 0.001) total −0.57, 0.001), white −0.61, deep grey matter −0.60, 0.001). Progressive associated 0.60, but not number new lesions. Conclusion: This study provides evidence progressive RRMS. Our findings also demonstrate that is linked lesions neurodegeneration periventricular patients.

Language: Английский

Citations

6
Segmentation of Cerebral MRI Images Using Fuzzy C-Means and Genetic Algorithm DOI

U. S. B. K. Mahalaxmi,

R. Anil Kumar,

N. N. S. V. Ramaraju

et al.

Advances in Science, Technology & Innovation/Advances in science, technology & innovation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in neuroimaging of multiple sclerosis DOI
Maria A. Rocca, Paolo Preziosa, Massimo Filippi

et al.

Current Opinion in Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Purpose of review To summarize recent advancements in understanding multiple sclerosis (MS) pathophysiology, predicting disease course, and monitoring treatment responses using MRI. Recent findings Paramagnetic rim lesions (PRLs) are highly specific to MS clinically relevant. Detected from the earliest phases, PRLs aid distinguishing other conditions, improving diagnostic accuracy. Moreover, associated with more severe disability measures brain damage may predict progression. Similarly, slowly expanding (SELs) a course. Disease-modifying therapies have limited effectiveness reducing or SELs. Choroid plexus (CP) enlargement is structural clinical predicts evolution. Enlarged perivascular spaces (ePVS) suggest microangiopathic changes rather than direct MS-related inflammation. Glymphatic dysfunction, evaluated diffusion tensor image analysis along space, emerges early correlates disability, cognitive impairment, damage. Aging comorbidities exacerbate damage, complicating diagnosis treatment. Emerging technologies, such as brain-age paradigms, aim disentangle aging MS-specific neurodegeneration. Summary Advances MRI highlighted significance chronic inflammation glymphatic dysfunction contributors progression well interplay between aging, MS.

Language: Английский

Citations

0
Choroid plexus volume changes in multiple sclerosis: insights from a systematic review and meta-analysis of magnetic resonance imaging studies DOI
Shahriar Kolahi, Diana Zarei, Mahbod Issaiy

et al.

Neuroradiology, Journal Year: 2024, Volume and Issue: 66(11), P. 1869 - 1886

Published: Aug. 6, 2024

Language: Английский

Citations

3
The Time Trajectory of Choroid Plexus Enlargement in Multiple Sclerosis DOI Open Access

Athina Andravizou,

S. Lorenzo, Evangelia Kesidou

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(7), P. 768 - 768

Published: April 1, 2024

Choroid plexus (CP) can be seen as a watchtower of the central nervous system (CNS) that actively regulates CNS homeostasis. A growing body literature suggests CP alterations are involved in pathogenesis multiple sclerosis (MS) but underlying mechanisms remain elusive. CPs enlarged and inflamed relapsing-remitting (RRMS) also clinically isolated syndrome (CIS) radiologically (RIS) stages, far beyond MS diagnosis. Increases choroid plexus/total intracranial volume (CP/TIV) ratio have been robustly associated with increased lesion load, higher translocator protein (TSPO) uptake normal-appearing white matter (NAWM) thalami, well annual relapse rate disability progression highly active RRMS individuals, not progressive MS. The CP/TIV has only slightly correlated magnetic resonance imaging (MRI) findings (cortical or whole brain atrophy) clinical outcomes (EDSS score) Therefore, we suggest volumetric assessments should mainly applied to early disease stages MS, whereas it taken into consideration caution In this review, attempt clarify pathological significance temporal (CPV) changes highlight pitfalls limitations analysis.

Language: Английский

Citations

2
ASCHOPLEX: A generalizable approach for the automatic segmentation of choroid plexus DOI Creative Commons
Valentina Visani, Mattia Veronese, Francesca B. Pizzini

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 182, P. 109164 - 109164

Published: Sept. 25, 2024

The Choroid Plexus (ChP) plays a vital role in brain homeostasis, serving as part of the Blood-Cerebrospinal Fluid Barrier, contributing to clearance pathways and being main source cerebrospinal fluid. Since involvement ChP neurological psychiatric disorders is not entirely established currently under investigation, accurate reproducible segmentation this structure on large cohorts remains challenging. This paper presents ASCHOPLEX, deep-learning tool for automated human from structural MRI data that integrates existing software architectures like 3D UNet, UNETR, DynUNet deliver volume estimates.

Language: Английский

Citations

2
Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis DOI
Martina Rubin, Paolo Preziosa, Monica Margoni

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. jnnp - 334913

Published: Oct. 10, 2024

Immune-mediated processes are implicated in the pathogenesis of fatigue, a common symptom multiple sclerosis (MS). The choroid plexus (CP) regulates central nervous system (CNS) immune homeostasis and undergoes volumetric modifications possibly contributing to MS-related fatigue. We explored association between CP volume changes fatigue dynamics.

Language: Английский

Citations

2