Journal of Magnetic Resonance Imaging, Journal Year: 2023, Volume and Issue: 59(5), P. 1708 - 1709
Published: Sept. 4, 2023
Language: Английский
Brain Structure and Function, Journal Year: 2025, Volume and Issue: 230(2)
Published: Jan. 27, 2025
Language: Английский
Citations
2
Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(2)
Published: Feb. 1, 2024
Entropy indicates irregularity of a dynamic system, with higher entropy indicating and more transit states. In the human brain, regional brain (BEN) has been increasingly assessed using resting state fMRI (rs-fMRI), while changes BEN during task-based have scarcely studied. The purpose this study is to characterize task-induced alterations large Human Connectome Project (HCP) data. To control potential modulation by block design, task-fMRI was calculated from images acquired task conditions only (task BEN) then compared rs-fMRI (resting BEN). Moreover, separately blocks runs (control BEN. Finally, test for residual effects in condition. With respect state, performance unanimously induced reduction peripheral cortical area increase centric part sensorimotor perception networks. Control showed similar alterations, suggesting effects. Task characterized reduced occipital, orbitofrontal, parietal regions.
Language: Английский
Citations
10
Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00556 - e00556
Published: March 1, 2025
Intermittent theta burst stimulation (iTBS), a novel protocol within repetitive transcranial magnetic (rTMS), has shown superior therapeutic effects for depression compared to conventional high-frequency rTMS (HF-rTMS). However, the neural mechanisms underlying iTBS remain poorly understood. Brain entropy (BEN), measure of irregularity brain activity, recently emerged as promising marker regional function and demonstrated sensitivity HF-rTMS. Given its potential, BEN may help elucidate iTBS. In this study, we computed using resting-state fMRI data from sixteen healthy participants obtained OpenNeuro. Participants underwent over left dorsolateral prefrontal cortex (L-DLPFC) at two different intensities (90 % 120 resting motor threshold (rMT)) on separate days. We used 2 × 2 repeated measures analysis variance (ANOVA) analyze interaction between intensity pre- vs. post-stimulation paired sample t-tests examine specific intensities. Additionally, spatial correlation was conducted determine whether altered baseline coupling neurotransmitter receptors/transporters, investigate potential changes induced by Our results indicate that subthreshold rMT) reduced striatal BEN, while suprathreshold (120 increased it. Subthreshold led in several receptor/transporter maps, primarily involving serotonin (5-HT), cannabinoid (CB), acetylcholine (ACh), glutamate (Glu). findings suggest is sensitive iTBS, with having distinct activity. Notably, offer more effective stimulation. This research highlights crucial role modulating activity lays groundwork future clinical studies focused optimizing outcomes through precise intensity.
Language: Английский
Citations
1
Medical & Biological Engineering & Computing, Journal Year: 2023, Volume and Issue: 61(12), P. 3159 - 3166
Published: Sept. 18, 2023
Language: Английский
Citations
14
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: April 27, 2024
Abstract Entropy indicates systematic irregularity and information capacity. Recent years have seen increasing interest in assessing regional brain entropy (BEN) using fMRI healthy controls (HCs) patients with various diseases. Depression anti-depressant related BEN alterations been reported several initial studies. Re-examining these effects independent cohort is crucial given the high complexity of depression. In this study, we used open data from OpenNeuro 46 mild to moderate depression 20 HCs examine its changes due nonpharmacological treatment (14 underwent treatment). Functional connectivity (FC) analysis was performed assess inter-regional relationship between regions showing rest brain. Compared HCs, showed increased left DLPFC, precuneus, limbic system, including amygdala, parahippocampal gyrus hippocampus. Increased amygdala were suppressed by a each individual patient. had positive FC right DLPFC negative areas, while abnormally lower or area. These seeded reverted after treatment. The findings highlight system effects, exhibit significant emotion dysregulation, which effectively addressed targeting top-down regulation functions mediated DLPFC-limbic system. Different existing literature, results suggest entropy/irregularity as potential mechanism underlying personalized marker for corresponding effects.
Language: Английский
Citations
6
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 16, 2024
Abstract Intermittent theta burst stimulation (iTBS) is a novel protocol of repetitive transcranial magnetic (rTMS). While iTBS has shown better therapeutic effects for depression than conventional high-frequency rTMS (HF-rTMS), its underlying neuronal mechanism remains elusive. Brain entropy (BEN), measure irregularity brain activity, recently emerged as marker regional activity. Our previous studies have the sensitivity BEN to and HF-rTMS, suggesting sensitive tool understanding iTBS. To assess this possibility, we calculated using resting state fMRI data provided by an open dataset in OpenNeuro. Sixteen healthy participants underwent 600 pulses applied over left dorsolateral prefrontal cortex (L-DLPFC) at two intensities (90% 120% individual motor threshold (rMT)) on separate days. We assessed pre-post difference associations with neurotransmitter receptor transporter binding maps. results showed that subthreshold rMT) decreased striatal BEN, while suprathreshold (120% increased BEN. also found significant differences spatial correlation between changes induced different various neurotransmitters. These suggest caused intensity may be related release other The study underscores significance provides basis future clinical investigations identify good benefits.
Language: Английский
Citations
4
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 19, 2024
Abstract Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain method effective in treating various neuropsychiatric disorders, yet its mechanisms are not fully understood. In general, rTMS protocols categorized into excitatory including high-frequency (HF-rTMS) and intermittent theta burst (iTBS), inhibitory low-frequency (LF-rTMS) continuous (cTBS). Brain entropy (BEN) measures irregularity, complexity of activity, our previous studies have indicated that BEN affects rTMS, HF-rTMS iTBS. However, two important questions remain whether equally sensitive to it can induce opposite activities, another question concerns specific changes across regions. To address these issues, we utilized own cTBS targeted on the left dorsal lateral prefrontal cortex (L-DLPFC) dataset publicly available LF-rTMS with stimulating sites L-DLPFC, temporal parietal junction (L-TPJ), occipital (L-OCC), from OpenNeuro. maps were calculated before after stimulation. The results showed L-DLPFC increased MOFC MOFC, subgenual anterior cingulate (MOFC/sgACC) putamen, regions consistent findings Additionally, L-TPJ resulted right TPJ, while L-OCC led decreased posterior (PCC). Our suggest only but also rTMS. Moreover, induces different effects regions, as detected by BEN.
Language: Английский
Citations
4
NeuroImage, Journal Year: 2025, Volume and Issue: 312, P. 121226 - 121226
Published: April 21, 2025
Language: Английский
Citations
0
Journal of Pain, Journal Year: 2025, Volume and Issue: unknown, P. 105421 - 105421
Published: April 1, 2025
Chronic pain is a debilitating clinical condition and severe public health issue that demands to be addressed. Neuroimaging-based techniques have been widely adopted investigate the neural underpinnings of chronic pain. Despite efforts complex nature experience as well heterogeneity made identification neuroimaging-based biomarkers extremely challenging. In this study, resting-state fMRI-based brain entropy, measure reflecting "irregularity" activity, was biomarker by comparing individuals with healthy controls in sample middle-to-old-age participants (n > 30,000) drawn from UK Biobank database. Abnormal entropy associated altered dynamics may serve potential marker disrupted processing Compared controls, exhibited increased broad set regions including frontal, temporal, occipital lobes, cerebellum. addition, more distributed showed lobes. When examining distinct types individually, only headache all over body differences compared matched controls. Perspective This article investigates substrates using randomness irregularity activity. could potentially aid assessment treatment
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 6, 2024
Abstract Entropy measures the irregularity or complexity of a system. Recent research on brain entropy (BEN) based resting-state fMRI has provided complementary information to other metrics such as low-frequency fluctuations and cerebral blood flow. It been established that neural plasticity, both pharmacological nonpharmacological, well stimulation can influence BEN. However, it remains unknown whether BEN reflect effects hormones. Furthermore, recent studies have indicated ovarian hormones behavioral inhibition activation systems. In our study, we utilized open-access available data from OpenNeuro investigate their impact BIS/BAS. Our results negative correlation between progesterone (PROG) in frontal-parietal network limbic system, while showed significant positive with BAS-drive DLPFC. Additionally, was observed PROG BAS-drive. Further analysis revealed DLPFC mediates This suggests reduces by increasing executive inhibitory functions We also analyzed FC whole brain. DLPFC-IPL BAS-drive, DLPFC-LOFC exhibited BAS-fun-seeking. Moreover, DLPFC-AG demonstrated BAS-rewards. These are consistent relationship impulsivity representation BAS. study is first demonstrate function. identified mediated left BEN, providing new insights into understanding behavior.
Language: Английский
Citations
3