Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis

Clinical Nutrition ESPEN, Journal Year: 2022, Volume and Issue: 51, P. 120 - 127

Published: Sept. 9, 2022

Language: Английский

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Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15188 - 15188

Published: Dec. 2, 2022

Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility disease severity. The present study was performed on 165 third-trimester pregnant women at time of delivery. Seventy-nine tested negative for SARS-CoV-2. From 86 testing positive, 32 were asymptomatic, 44 presented a mild form disease, 10 experienced severe symptoms. Serum 25-OH levels measured blood samples collected admission. Low detected symptomatic but not asymptomatic patients compared to healthy (

Language: Английский

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Acute painful crises may be causes of sudden deaths in sickle cell diseases

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Background: Sickle cell diseases (SCDs) are severe inflammatory processes on vascular endothelium, especially at the capillary level because system is actual distributor of hardened red blood cells (RBCs) into tissues. Methods: All cases with SCDs were included. Results: We studied 222 males and 212 females similar mean ages (30.8 vs 30.3 years, p>0.05, respectively). Disseminated teeth losses (5.4% 1.4%, p<0.001), ileus (7.2% cirrhosis (8.1% 1.8%, leg ulcers (19.8% 7.0%, digital clubbing (14.8% 6.6%, coronary heart disease (18.0% 13.2%, p<0.05), chronic renal (9.9% 6.1%, obstructive pulmonary (25.2% stroke (12.1% 7.5%, p<0.05) all higher in but not acute chest syndrome (2.7% 3.7%), hypertension (12.6% 11.7), deep venous thrombosis and/or varices telangiectasias (9.0% 6.6%), or age mortality (30.2 33.3 years) (p>0.05 for all). Conclusion: The RBCs-induced endothelial damage, inflammation, edema, fibrosis initiated birth, terminate disseminated tissue hypoxia multiorgan failures even childhood SCDs. Although RBCs supports corticosteroids phase aspirin plus hydroxyurea both phases decrease severity diseases, survivals still shortened genders, dramatically. Infections, medical surgical emergencies, emotional stresses-induced increased basal metabolic rate aggravates sickling may painful crises, failures, sudden deaths. Key words: deaths, atherosclerosis, aging

Language: Английский

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Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 996 - 996

Published: Aug. 17, 2024

Evidence is increasing that vitamin D and CYP11A1-derived D, tachysterol, lumisterol metabolites play a significant antioxidant role beyond its classical functions in bone health calcium metabolism. Several recent studies have linked these elements to reduced oxidative stress as well improved immune, cardiovascular, neurological result of chronic kidney disease cancer. Additionally, supplementation with this has been shown be one the most cost-effective micronutrient interventions worldwide, highlighting potential therapeutic approach. The underlying mechanisms implications function or are not understood. This comprehensive narrative review aimed at summarizing current evidence regarding molecular implicated provide general overview identify key research areas for future, offering an extensive perspective can guide both researchers clinicians management diseases associated and/or insufficient status.

Language: Английский

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Superoxide dismutase alterations in COVID-19: implications for disease severity and mortality prediction in the context of omicron variant infection

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Background In the few reports to date, changes in superoxide dismutase (SOD), a key factor cellular protection against superoxide, COVID-19 have been very inconsistent and contradictory. There is also lack of data on induced by Omicron variant. Further investigation warranted figure out SOD alterations COVID-19, particularly within context ongoing variant infection, which may provide clues its role pathogenesis open up new avenues for treatment. Methods activity 109 patients (including 46 severe cases 63 mild moderate cases) 30 matched healthy controls were quantified. Demographic data, blood cell counts, biochemical indicators, coagulation inflammatory markers recorded. Results SOD, an important node, experienced significant decrease with exhibiting lower compared control healthy. Notably, who deceased had lowest activity. Correlation analysis revealed correlations between markers, organ injury dysfunction nutritional lymphocytes counts. The ROC curve showed good performance differentiation prediction death. Conclusion was significantly decreased infected correlated systemic changes, could be used as biomarker assess disease severity predict mortality clinical pathway management. Additionally, this finding will contribute exploring potential direction treatment patients.

Language: Английский

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The Variable Nature of Vitamin C—Does It Help When Dealing with Coronavirus?

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1247 - 1247

Published: June 24, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading worldwide. For this reason, new treatment methods are constantly being researched. Consequently, and already-known preparations investigated to potentially reduce the severe course of disease 2019 (COVID-19). SARS-CoV-2 infection induces production pro-inflammatory cytokines serum biomarkers in host organism. In addition antiviral drugs, there other substances used COVID-19, e.g., those with antioxidant properties, such as vitamin C (VC). Exciting aspects use VC therapy its pro-oxidative abilities. review, we summarized both positive effects using treating infections caused by light available research. We have tried answer question whether high doses brings expected benefits COVID-19 correct therapeutic choice. Each case requires individual assessment determine positives outweigh negatives, especially populational studies concerning genetic differentiation genes encoding solute carriers responsible forVC adsorption. Few data on influence infection. Deducing from already-published data, high-dose intravenous (HDIVC) does not significantly lower mortality or length hospitalization. However, some prove, among things, impact levels inflammatory markers. Finally, non-positive effect administration mainly neutral, but negative that it can result urinary stones nephropathies.

Language: Английский

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Oxidative Stress Biomarkers and Their Association with Mortality among Patients Infected with SARS-CoV-2 in Mexico

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 8

Published: June 17, 2022

Activation of the immune system response is associated with generation oxidative stress (OS). Several alterations are involved in OS, such as excessive production reactive oxygen species (ROS) and decreased antioxidant activity, which together lead to an imbalance redox status. The role OS during SARS-CoV-2 infection not fully understood. aim this study was determine biomarkers assess their usefulness a predictor mortality COVID-19 patients.Baseline characteristics serum samples were collected from hospitalized patients compared healthy controls. biomarkers, including malondialdehyde (MDA) total capacity (TAC), assessed by spectrophotometric radical absorbance (ORAC) methods, respectively.A 152 individuals analyzed (COVID-19 vs. controls). Compared controls (n = 76), infected 76) presented higher levels MDA (p < 0.001) TAC 0.001). A 37 (49%) died. area under receiver operating characteristic (ROC) curve (AUC) estimated that combination (MDA+TAC) (AUC 0.6394, p 0.037) significant mortality. level (HR, 1.05, 95% CI, 1.00-1.10, 0.045).This concludes increased To our knowledge, first evidence expression association among Mexican population.

Language: Английский

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The Effectiveness of Problem-Based Learning in Improving Critical Thinking and Problem-Solving Skills in Medical Students: A Systematic Review of Fifteen Years’ Experience (2005-2019)

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Background: An ongoing challenge for medical education in the twenty-first century is determining best method to foster problem-solving and critical thinking learners. These higher-order aptitudes help prepare doctors practice a rapidly evolving health system. In education, Problem-Based Learning (PBL) an instructional pedagogy which pupils are challenged seek answers authentic patient scenarios small groups. PBL techniques proposed as one enhance pupils’ learning abilities including problem-solving. Aim: This systematic review was conducted search evidence from past fifteen years of literature, demonstrating capability improve skills students. Review Question: Is there support problem solving students? Methods: The process through electronic databases on publications related impact PBL, particularly, two fundamental skills; restricted publicationsbetween January 1, 2005 December 31, 2019. Four were searched, namely; Medline, PubMed, EMBASE Scopus. Best Evidence Medical Education (BEME) guidelines utilised guide way this conducted. Quality assessment performed rating evaluation methods included studies. employing five-point Likert scale (1= strongly disagree 5= agree) each study relation three items; appropriateness design, implementation well data analysis. then mapped grade 1 (low) 5 (high), aligns with BEME strength findings. Results: Searching four aforementioned produced 657 publications, 249 duplicates. Therefore, 408 screened based their titles against inclusion exclusion criteria, leaving 86 articles screen abstracts. A further 9 manually obtained such that total 95 Forty-one met criteria full text review. Following review, twenty-nine excluded. twelve studies findings follows; only reviewed graded 5, 4, six 3. Of reviewed, five provided among Two these while Discussion: available limited claim improves students’ aptitudes. Only claim, remaining seven did not. assessed knowledge, comprehension, application domains, student perspectives. studies, where description either case-analysis tests or modified essay questions, not give actual indication measuring skills. Another describe written i.e. proxy questions purported measure skills, prevented use specified question. reported scores final significantly (p>0.05) compared initial assessment. Conclusion: There very little published over last supporting recent evidence. As such, investigations required legitimise claims Key words: Learning, Critical Thinking Problem-Solving Skills, Students

Language: Английский

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Pregnancy and COVID-19: The Possible Contribution of Vitamin D

Nutrients, Journal Year: 2022, Volume and Issue: 14(16), P. 3275 - 3275

Published: Aug. 10, 2022

Vitamin D deficiency has been associated with the severity of COVID-19. The role vitamin in pregnant women COVID-19 poorly investigated to date. aim this study was evaluate influence affecting some clinical features pregnancy between SARS-CoV-2 positive and negative patients. pathway related polymorphisms 25-hydroxyvitamin levels were quantified followed from first third trimester pregnancy. considered values ≤ 30 ng/mL. In total, 160 enrolled: 23 resulted for at least one test (molecular swab or antibody tests). D-associated able affect subjects: remarkably, all VDR TaqICC genotype patients SARS-CoV-2. a sub-population (118 patients), correlated pregnancy-related factors, such as alpha-fetoprotein levels. Third-trimester lower preterm births compared full-term pregnancy: trend highlighted This is demonstrating characteristics during era. Further studies larger different cohorts are required confirm these findings.

Language: Английский

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COVID-19 in Pregnancy: Influence of Body Weight and Nutritional Status on Maternal and Pregnancy Outcomes—A Review of Literature and Meta-Analysis

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1052 - 1052

Published: Feb. 20, 2023

In the last two and a half years, COVID-19 has been one of most challenging public health issues worldwide. Based on available evidence, pregnant women do not appear to be more susceptible infection than general population but having during pregnancy may increase risk major complications for both mother fetus. The aim this study is identify correlation between BMI nutritional status likelihood contracting in pregnancy, its severity, maternal outcomes. We carry out systematic literature search meta-analysis using three databases following guidelines Cochrane Collaboration. include 45 studies about COVID-19-positive women. Compared with normal-weight COVID-19, obesity associated severe (OR = 2.32 [1.65–3.25]), increased death 2.84 [2.01–4.02]), higher rate hospital admission 2.11 [1.37–3.26]). Obesity adverse outcomes by increasing symptom severity and, consequently, Intensive Care Unit (ICU) admission, finally, rates. For micronutrients, results are less definite, even if there seems lower level particular Vitamin D,

Language: Английский

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