Shared 6mer Peptides of Human and Omicron (21K and 21L) at SARS-CoV-2 Mutation Sites DOI Creative Commons
Yekbun Adıgüzel, Yehuda Shoenfeld

Antibodies, Journal Year: 2022, Volume and Issue: 11(4), P. 68 - 68

Published: Oct. 25, 2022

We investigated the short sequences involving Omicron 21K and 21L variants to reveal any possible molecular mimicry-associated autoimmunity risks changes in those. first identified common 6mers of viral human protein present for both mutant (Omicron) nonmutant (SARS-CoV-2) versions same sequence then predicted binding affinities those HLA supertype representatives. evaluated change potential risk, through comparative assessment their similar peptides with allele. This is lost new, or de novo, associated mutations variants. Accordingly, e.g., affinity virus-similar Ig heavy chain junction regions shifted from HLA-B*15:01 HLA-A*01:01 allele at sequences. Additionally, different proteins sharing SARS-CoV-2 mutation sites interest HLA-B*07:02 allele, such as respective sequences, were lost. Among all, novel risk appeared be prominent HLA-A*24:02 HLA-B*27:05 serotypes upon infection 21L. Associated disease, pathway, tissue expression data supported new serotypes, while could have been diminished, HLA-A*03:01 retained, individuals infected under study. These are likely affect complications related cross-reactions influencing relevant

Language: Английский

Azvudine therapy of common COVID‐19 in hemodialysis patients DOI Creative Commons
Shunlai Shang, Bo Fu,

Yanqiu Geng

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(8)

Published: July 31, 2023

Abstract There is no antiviral study on hemodialysis patients infected with coronavirus disease 2019 (COVID‐19), especially the application of 2′‐deoxy‐2′‐β ‐fluoro‐4′‐azidocytidine (Azvudine, FNC) therapy. We conducted a multicenter observational involving 1008 patients. After matching for age, sex, and other factors, 182 in basic treatment group FNC were included. The negative nucleic acid conversion rate was significantly higher than that group, viral loads, interleukin‐6, C‐reactive protein lower those ( p < 0.05). significant differences liver function, renal or number adverse events between two groups > In conclusion, our has provided novel evidence suggesting scheme may be safe effective compared to common COVID‐19.

Language: Английский

Citations

16
The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2 DOI Creative Commons

Letian Fang,

Jie Xu,

Yue Zhao

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 25, 2023

Over three years’ pandemic of 2019 novel coronavirus disease (COVID-19), multiple variants and subvariants have emerged successively, outcompeted earlier become predominant. The sequential emergence reflects the evolutionary process mutation-selection-adaption severe acute respiratory syndrome 2 (SARS-CoV-2). Amino acid substitution/insertion/deletion in spike protein causes altered viral antigenicity, transmissibility, pathogenicity SARS-CoV-2. Early pandemic, D614G mutation conferred virus with advantages over previous increased it also laid a conservative background for subsequent substantial mutations. role genomic recombination evolution SARS-CoV-2 raised increasing concern occurrence recombinants such as Deltacron, XBB.1.5, XBB.1.9.1, XBB.1.16 late phase pandemic. Co-circulation different co-infection immunocompromised patients accelerate recombinants. Surveillance variations, particularly recombination, is essential to identify ongoing changes genome antigenic epitopes thus leads development new vaccine strategies interventions.

Language: Английский

Citations

15
Antibody responses in Omicron BF.7-infected patients vaccinated with inactivated SARS-CoV-2 DOI
Yabo Zhao, Weili Li, Liming Xu

et al.

Virology, Journal Year: 2025, Volume and Issue: 603, P. 110404 - 110404

Published: Jan. 11, 2025

Language: Английский

Citations

0
Viroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization DOI
Antonio Alcaraz, José L. Nieva

Quarterly Reviews of Biophysics, Journal Year: 2025, Volume and Issue: 58

Published: Jan. 1, 2025

Abstract The ‘Viroporin’ family comprises a number of mostly small-sized, integral membrane proteins encoded by animal and plant viruses. Despite their sequence structural diversity, viroporins share common functional trend: capacity to assemble transmembrane channels during the replication cycle virus. Their selectivity spectrum ranges from low-pH-activated, unidirectional proton transporters, size-limited permeating pores allowing passive diffusion metabolites. Through mechanisms not fully understood, expression facilitates virion assembly/release infected cells, subverts cell physiology, contributing cytopathogenicity. Compounds that interact with interfere membrane-permeabilizing activity in vitro , are known inhibit virus production. Moreover, viroporin-defective viruses comprise source live attenuated vaccines prevent infection notorious human livestock pathogens. This review dives into origin evolution viroporin concept, summarizes some methodologies used characterize structure–function relationships these important virulence factors, attempts classify them on biophysical grounds attending ion/solute transport across membranes.

Language: Английский

Citations

0
Genomic Epidemiology of the Main SARS‐CoV‐2 Variants Circulating in Italy During the Omicron Era DOI Creative Commons
Annalisa Bergna, Alessia Lai,

Fabio Sagradi

et al.

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(2)

Published: Feb. 1, 2025

ABSTRACT Since early 2022 the Omicron variant has rapidly spread worldwide, becoming dominant to date. The study aimed investigate clinical and epidemiological characteristics of COVID‐19 patients reconstruct genomic epidemiology main SARS‐CoV‐2 sublineages in Italy 2022. A total 8970 samples were studied, phylogenetic analyses focused on BA.1, BA.2, BA.5 subvariants. More than half subjects received three doses vaccine experienced a reinfection. significant larger proportion unvaccinated presented reinfection compared with vaccinated. Clusters tMRCA between September–November 2021 (BA.1), November 2021–January (BA.2), October 2021–May (BA.5). R e values showed highest level September–October, January–February 2022, May for BA.2 BA.5, respectively. Limited number studied sequences are included clusters. rate exceeded its evolutionary rate. No single sublineage had sufficient time differentiate into large clusters, but only small fragmented groups sharing same recent ancestor. These dissect dynamics over period great changes epidemic.

Language: Английский

Citations

0
The relationship between selenium and viral diseases DOI Creative Commons
Jiali Li,

Jia Lai,

Yucheng Zeng

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Selenium (Se) is a trace element that fulfills vital functions in the organism. Over past few years, numerous studies have revealed profound connection between and its therapeutic potential addressing various viral infectious diseases. can boost activity of immune cells counteract oxidative damage caused by free radicals to prevent replication viruses. Studies shown protects against wide range viruses such as DNA viruses, hepatitis B virus, RNA human immunodeficiency virus coxsackie virus. probably one research directions for antiviral drugs future. This review summarizes use therapy progress.

Language: Английский

Citations

0
Cracking the code of a correlate of protection against SARS-CoV-2 breakthrough infection in cancer patients DOI Creative Commons
Yana Debie, Irene Garcia-Fogeda, Lander Willem

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 6, 2025

The level of protection against SARS-CoV-2 breakthrough infections conferred by the presence anti-S1 antibodies (IgGs) in cancer patients is still understudied. This work examines existence an immunoglobulin G (IgG) -based correlate (CoP) established prospectively collected observational data about with different variants a large cohort study vaccinated patients. 760 were longitudinally followed-up, starting before first vaccination until six months after second booster. Anti-S1 IgGs quantified serum samples (N = 2958) and monitored using questionnaires, routine COVID-19 testing medical chart review. A Generalized Estimating Equations approach was used to model binary infection status as endpoint relation IgG titers. It observed that higher titers correspond lower probability infection. For early pandemic phase, protective titer above 20.42 BAU/mL observed. However, emergence Omicron variant, are required be protective, but no clear CoP could identified.

Language: Английский

Citations

0
Evaluating gene expression patterns for NF-κB1, TNF, and VEGF A& VEGF B in a mouse model of SARS-CoV-2 infection. DOI Creative Commons
Wael Hafez, Asrar Rashid, Feras Al‐Obeidat

et al.

Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100124 - 100124

Published: March 1, 2025

Language: Английский

Citations

0
Persistent Nucleic Acids from Endemic Human Coronaviruses in Adenoids: Do They Enhance Children's Immune Response to SARS-CoV-2 Infection? DOI Creative Commons

Kai Winkler,

Lucia Otten,

Alina Abramian

et al.

Journal of Clinical Virology Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100208 - 100208

Published: March 1, 2025

Language: Английский

Citations

0
Unraveling the Dynamics of Omicron (BA.1, BA.2, and BA.5) Waves and Emergence of the Deltacron Variant: Genomic Epidemiology of the SARS-CoV-2 Epidemic in Cyprus (Oct 2021–Oct 2022) DOI Creative Commons
Andreas C. Chrysostomou, Bram Vrancken,

Christos Haralambous

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(9), P. 1933 - 1933

Published: Sept. 15, 2023

Commencing in December 2019 with the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), three years disease (COVID-19) pandemic have transpired. The virus has consistently demonstrated a tendency for evolutionary adaptation, resulting mutations that impact both immune evasion and transmissibility. This ongoing process led to successive waves infections. study offers comprehensive assessment spanning genetic, phylogenetic, phylodynamic, phylogeographic dimensions, focused on trajectory SARS-CoV-2 epidemic Cyprus. Based dataset comprising 4700 viral genomic sequences obtained from affected individuals between October 2021 2022, our analysis is presented. Over this timeframe, total 167 distinct lineages sublineages emerged, including variants such as Delta Omicron (1, 2, 5). Notably, during fifth wave infections, subvariants 1 gained prominence, followed by ascendancy 5 subsequent sixth wave. Additionally, (December 2021-January 2022), unique set genetic associated variant 1, dubbed "Deltacron", was identified. phenomenon initially evoked skepticism, characterized concerns primarily centered around contamination or coinfection plausible etiological contributors. These hypotheses were predominantly disseminated through unsubstantiated assertions within realms social mass media, lacking concurrent scientific evidence validate their claims. Nevertheless, exhaustive molecular analyses presented occurrences would likely lead frameshift mutation-a aberration conspicuously absent provided sequences. substantiates accuracy initial assertion while refuting potential etiologies. Comparable observations global scale dispelled doubt, eventually leading recognition Delta-Omicron community monitoring World Health Organization (WHO). As investigation delved deeper into intricate dynamics Cyprus, discernible pattern highlighting major role international connections shaping virus's local trajectory. United States Kingdom central conduits governing entry exit Moreover, notable migratory routes included nations Greece, South Korea, France, Germany, Brazil, Spain, Australia, Denmark, Sweden, Italy. empirical findings underscore spread Cyprus markedly influenced influx new, highly transmissible variants, triggering infection. elucidates new infection advent contagious notably an abundance localized spike protein. discovery decisively contradicts hitherto hypothesis seasonal fluctuations epidemiological dynamics. emphasizes importance meticulously examining genetics alongside migration patterns specific region. Past experiences also emphasize substantial viruses SARS-CoV-2, underscoring need sustained vigilance. However, pandemic's continue evolve, balanced approach caution resilience becomes paramount. ethos encourages founded informed prudence self-preservation, guided public health authorities, rather than enduring apprehension. Such empowers societies adapt progress, fostering poised confidence rooted well-founded adaptation.

Language: Английский

Citations

9