Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report DOI Creative Commons
Sheridan J.C. Baker, Landry Nfonsam,

Daniela Leto

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 4, 2024

Abstract Background The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 virus, emerged in late 2019 and spready globally. Many effects of infection with this pathogen are still unknown, both chronic repeated producing novel pathologies. Case presentation An immunocompromised patient presented infection. had history Hodgkin’s lymphoma, treated chemotherapy stem cell transplant. During course their treatment, eleven respiratory samples from were analyzed whole-genome sequencing followed lineage identification. Whole-genome virus present over time revealed that at various timepoints harboured three different lineages virus. was initially infected B.1.1.176 before coinfection BA.1. When coinfected BA.1, viral populations found approximately equal proportions within based on read abundance. Upon further sampling, during final two to be BA.2.9. eventually developed failure died. Conclusions This case study shows an example changes can happen who is multiple times. Furthermore, demonstrates how simultaneous lead unclear assignment standard methods, which resolved investigation. analyzing reinfection cases, care must taken properly identify present.

Language: Английский

Handheld NIR-to-NIR Platform for on-site evaluating protective neutralizing antibody against SARS-CoV-2 ancestral strain and Omicron variant after vaccination or infection DOI

Qingwei Song,

Lei Zhao,

Weikang Mai

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 234, P. 115353 - 115353

Published: April 25, 2023

Language: Английский

Citations

14
The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2 DOI Creative Commons

Letian Fang,

Jie Xu,

Yue Zhao

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 25, 2023

Over three years’ pandemic of 2019 novel coronavirus disease (COVID-19), multiple variants and subvariants have emerged successively, outcompeted earlier become predominant. The sequential emergence reflects the evolutionary process mutation-selection-adaption severe acute respiratory syndrome 2 (SARS-CoV-2). Amino acid substitution/insertion/deletion in spike protein causes altered viral antigenicity, transmissibility, pathogenicity SARS-CoV-2. Early pandemic, D614G mutation conferred virus with advantages over previous increased it also laid a conservative background for subsequent substantial mutations. role genomic recombination evolution SARS-CoV-2 raised increasing concern occurrence recombinants such as Deltacron, XBB.1.5, XBB.1.9.1, XBB.1.16 late phase pandemic. Co-circulation different co-infection immunocompromised patients accelerate recombinants. Surveillance variations, particularly recombination, is essential to identify ongoing changes genome antigenic epitopes thus leads development new vaccine strategies interventions.

Language: Английский

Citations

14
COVID-19 pandemic sheds a new research spotlight on antiviral potential of essential oils – A bibliometric study DOI Creative Commons
Binawati Ginting, Williams Chiari, Teuku Fais Duta

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(7), P. e17703 - e17703

Published: June 30, 2023

Essential oils are thought as potential therapies in managing coronavirus disease 2019 (COVID-19). Many researchers have put their efforts to tackle the pandemic by exploring antiviral candidates which consequently changes research landscape. Herein, we aimed assess effect of COVID-19 toward landscape essential oil research.

Language: Английский

Citations

13
Rapid classification of SARS-CoV-2 variant strains using machine learning-based label-free SERS strategy DOI

Jingwang Qin,

Xiangdong Tian, Siying Liu

et al.

Talanta, Journal Year: 2023, Volume and Issue: 267, P. 125080 - 125080

Published: Aug. 17, 2023

Language: Английский

Citations

13
Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report DOI Creative Commons
Sheridan J.C. Baker, Landry Nfonsam,

Daniela Leto

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 4, 2024

Abstract Background The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 virus, emerged in late 2019 and spready globally. Many effects of infection with this pathogen are still unknown, both chronic repeated producing novel pathologies. Case presentation An immunocompromised patient presented infection. had history Hodgkin’s lymphoma, treated chemotherapy stem cell transplant. During course their treatment, eleven respiratory samples from were analyzed whole-genome sequencing followed lineage identification. Whole-genome virus present over time revealed that at various timepoints harboured three different lineages virus. was initially infected B.1.1.176 before coinfection BA.1. When coinfected BA.1, viral populations found approximately equal proportions within based on read abundance. Upon further sampling, during final two to be BA.2.9. eventually developed failure died. Conclusions This case study shows an example changes can happen who is multiple times. Furthermore, demonstrates how simultaneous lead unclear assignment standard methods, which resolved investigation. analyzing reinfection cases, care must taken properly identify present.

Language: Английский

Citations

5