Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

Introduction: The severe cases of COVID-19, a disease caused by acute respiratory syndrome coronavirus-2 (SARS-CoV-2), often present with kidney injury (AKI). Although old age and preexisting medical conditions have been identified as principal risk factors for COVID-19-associated AKI, the molecular basis behind such connection remains unknown. In this study, we investigated pathogenic role Klotho deficiency in AKI explored therapeutic potential Klotho-derived peptide 1 (KP1). Methods: We assessed susceptibility deficient Kl/Kl mice to developing after expression SARS-CoV-2 N protein. KP1 ameliorating tubular was using cultured proximal cells (HK-2) vitro mouse model ischemia-reperfusion (IRI) vivo . Results: Renal markedly downregulated various chronic (CKD) models aged mice. Compared wild-type counterparts, mutant KL/KL were susceptible overexpression protein developed lesions resembling AKI. , alone induced HK-2 express markers injury, cellular senescence, apoptosis epithelial-mesenchymal transition, whereas both abolished these lesions. Furthermore, mitigated dysfunction, alleviated inhibited IRI Conclusion: These findings suggest that is key determinant As such, KP1, small recapitulating function, could be an effective alleviating COVID-19 patients.

Language: Английский

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In silico evidence implicating novel mechanisms of Prunella vulgaris L. as a potential botanical drug against COVID-19-associated acute kidney injury

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: May 18, 2023

COVID-19-associated acute kidney injury (COVID-19 AKI) is an independent risk factor for in-hospital mortality and has the potential to progress chronic disease. Prunella vulgaris L ., a traditional Chinese herb that been used treatment of variety diseases centuries, could have treat this complication. In study, we studied protective role in COVID-19 AKI explored its specific mechanisms applied by network pharmacology bioinformatics methods. The combination protein-protein interaction Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment -target gene revealed eight key target genes (VEGFA, ICAM1, IL6, CXCL8, IL1B, CCL2, IL10 RELA). Molecular docking showed all these gene-encoded proteins be effectively bound three major active compounds (quercetin, luteolin kaempferol), thus becoming therapeutic targets. dynamics simulation also supports binding stability RELA-encoded protein with quercetin luteolin. Together, our data suggest VEGFA, RELA drug targets inhibiting NF-κB signaling pathway. Our silico studies shed new insights into P. ingredients, e.g., quercetin, as botanical drugs against AKI, warrant further on efficacy mechanisms.

Language: Английский

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Editorial on the Special Issue “Advances in Pediatric Acute Kidney Injury”

Children, Journal Year: 2024, Volume and Issue: 11(2), P. 195 - 195

Published: Feb. 3, 2024

Acute kidney injury (AKI) refers to a swift decline in function, marked by the reduced excretion of waste products and disturbances fluid electrolyte balance [...]

Language: Английский

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Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series

Integrative Medicine in Nephrology and Andrology, Journal Year: 2024, Volume and Issue: 11(1)

Published: Feb. 26, 2024

ABSTRACT Background: Due to their chronic immunocompromised status, kidney transplant (KT) recipients face escalated risks from coronavirus disease 2019 (COVID-19), which may be exacerbated by lower vaccination rates. However, there is a paucity of information regarding the clinical traits unvaccinated KT with COVID-19. We aimed investigate characteristics and outcomes severe acute respiratory syndrome 2 (SARS-CoV-2) Omicron infection in recipients. Methods: In this retrospective study, we analyzed 36 diagnosed SARS-CoV-2 infection, as confirmed reverse transcription polymerase chain reaction. Clinical characteristics, laboratory tests, treatment regimens, were examined, 2-month follow-up assessments conducted. Results: had high incidence 66.7% classified having severe/critical illness. Factors associated illness included age; diabetes mellitus; lung computed tomography score; elevated serum D-dimer, interleukin-6, C-reactive protein, procalcitonin, ferritin levels. The patients group also significantly blood lymphocyte counts albumin Treatment strategies discontinuation antimetabolic drugs, reduction or calcineurin inhibitor antiviral therapy, early patient-tailored nutritional support. Acute injury was observed 19.4% patients. Four (11.1%) died during observation period, two (5.6%) succumbing hospitalization period due infection. remaining did not report any significant symptoms are still undergoing follow-up. Conclusion: Early diagnosis, personalized treatment, vigilant monitoring all crucial aspects management These findings contribute understanding COVID-19 KT.

Language: Английский

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Research on coronavirus disease 2019 and the kidney: A bibliometric analysis

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31749 - e31749

Published: May 25, 2024

In addition to damage the lungs, coronavirus disease 2019 (COVID-19) can multiple organs, including kidney. Our purpose was analyze research hotspots and trends in COVID-19 kidney diseases using bibliometrics help clarify development direction of this field.

Language: Английский

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Clinical characteristics and outcomes of unvaccinated kidney transplant patients infected with SARS-CoV-2 omicron subvariant BA.5.2

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 10, 2023

Abstract Background Kidney transplant (KT) recipients, who are chronically immunocompromised, face increased risks due to COVID-19 and lower vaccination rates. Limited knowledge exists regarding the clinical characteristics of unvaccinated KT patients with COVID-19. This study aimed examine features outcomes infected SARS-CoV-2 omicron subvariant BA.5.2. Methods The enrolled 36 compared them 20 control cases without underlying medical conditions. Clinical characteristics, laboratory tests, treatment regimens, were analyzed. RT-PCR confirmed Omicron BA.5.2 infection. Results experienced severe disease, 66.7% classified as severe/critical illness. Dyspnea on admission, blood leukocyte lymphocyte counts, hemoglobin levels, serum albumin levels more prevalent in group group. Severe/critical illness was associated factors such age, diabetes mellitus, lung infection CT score, elevated D-dimer, IL-6, CRP, Procalcitonin, ferritin. Blood counts significantly patients. Treatment included discontinuation anti-metabolic drugs, reduction, or calcineurin inhibitor antiviral therapy, early patient-tailored nutritional support. Acute kidney injury observed 19.4% cases, four died during observation period. Conclusions Early diagnosis, personalized diligent monitoring crucial for These findings contribute understanding management population.

Language: Английский

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A Case of Long COVID-19 Myocarditis with Asymptomatic Manifestation in a Young Male

Galician Medical Journal, Journal Year: 2023, Volume and Issue: 30(3), P. E202337 - E202337

Published: Sept. 1, 2023

Background. Myocarditis is one of the most dangerous complications both acute phase COVID-19 and long COVID-19, with a rather heterogeneous clinical presentation that ranges from asymptomatic to life-threatening. The diverse high risk further complications, on hand, good prognosis in case appropriate treatment, other demand great attention doctors. Case Report. We report 27-year-old male presented cardiologist complaints dyspnea, chest pain, palpitation occurred eight months after mild episode. diagnostic search commenced detailed questioning physical examination laboratory testing instrumental procedures, including resting electrocardiography, two-dimensional speckle-tracking echocardiography, stress echocardiography. Gadolinium-enhanced cardiac magnetic resonance was final step diagnosis establishment. Half-a-year follow-up period patient manifestation myocarditis demonstrated normalization condition prescribed pathogenetic treatment. Conclusions. This raises awareness need for prolonged patients an episode proposes comprehensive approach possible differential precise treatment young rationale based relevant literature.

Language: Английский

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