Multiple sclerosis and COVID-19: a bidirectional Mendelian randomization study DOI Creative Commons

Shitong Liu,

Yixin Liang,

Binbin Sheng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

This study aimed to investigate the potential relationship between multiple sclerosis (MS) and coronavirus disease 2019 (COVID-19) outcomes using Mendelian randomization analysis. Specifically, it evaluates whether genetic factors, including single-nucleotide polymorphism (SNP) rs10191329, influence susceptibility of MS patients three COVID-19 [severe acute respiratory syndrome 2 (SARS-CoV-2) infection, hospitalized COVID-19, severe COVID-19]. utilized genome-wide association summary statistics from International Multiple Sclerosis Genetics Consortium conduct a SNPs strongly associated with were selected examine their impact on outcomes. The analysis focused identifying any causal associations severity, as well assessing role interferon beta (IFNβ) treatment in modifying these results suggest an increased risk but individuals carrying rs10191329 SNP appeared less likely develop COVID-19. SNP, located within DYSF-ZNF638 locus, may immune responses highlighting its relevance for personalized strategies. Importantly, no significant was found IFNβ outcomes, indicating that findings treated differ those observed untreated patients. suggests offer protective effects against SARS-CoV-2 These underscore importance such shaping clinical context Further research should explore targeted therapies approaches managing during ongoing pandemic.

Language: Английский

Impact of COVID infection on the course of multiple sclerosis DOI

Valeriya Volkova,

M. N. Bokser,

Y. S. Sarkisyan

et al.

Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery), Journal Year: 2025, Volume and Issue: 1, P. 60 - 73

Published: Jan. 15, 2025

One of the most pressing questions regarding COVID-19 pandemic outbreak is to determine its impact on major neurological diseases. The infection poses a particular threat people with comorbidities and citizens over 60 years age. Reports disease have raised concern among neurologists treating autoimmune diseases, including multiple sclerosis. Previous studies shown an association between viral infections, sclerosis relapses, MRI lesions. Although exact mechanism unclear, infections are thought trigger systemic inflammatory response leading increased expression pro-inflammatory cytokines chemokines. Changes in mediators critical pathogenesis symptoms may possibly increase susceptibility relapses Given previous reports as demyelination, it important investigate whether lead rate or progression disability. In this regard, article reviews current relevant research observational findings that relate covid course

Language: Английский

Citations

0
Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder DOI Creative Commons
Yuqing Song, Yi Zhao, Ancha Baranova

et al.

Psychiatric Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD) are two neurodevelopmental disorders that often result in individuals experiencing traumatic events. However, little is known about the connection between ADHD/ASD post-traumatic stress (PTSD). This study aimed to investigate genetic associations these disorders. Methods Genetic correlation analysis was used examine components shared ADHD (38 691 cases 275 986 controls), ASD (18 381 27 969 controls) PTSD (23 212 151 447 controls). Two-sample Mendelian randomization analyses were employed explore bidirectional causal relationships PTSD. Results The results of revealed significant positive correlations with ADHD(r g = 0.70) (r 0.34). Furthermore, liabilities [odds ratio (OR) 1.14; 95% confidence interval (CI), 1.06–1.24; P 7.88 × 10 −4 ] (OR 1.04; CI, 1.01–1.08; 0.014) associated an increased risk developing later life. no evidence supported liability could elevate or ASD. Conclusion findings this may increase PTSD, but not vice versa.

Language: Английский

Citations

3
Causal associations between COVID-19 and childhood mental disorders DOI Creative Commons
Fei Chen, Hongbao Cao, Ancha Baranova

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 8, 2023

Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade both the peripheral and central nervous systems impact function of brain. Therefore, it is necessary to evaluate mutual influences between COVID-19 outcomes childhood mental disorders. Methods We examined genetic correlations potential causalities three disorders phenotypes by genetically proxied analyses. included attention-deficit/hyperactivity disorder (ADHD, N = 292,548), Tourette’s (TS, 14,307), autism spectrum (ASD, 46,350). traits SARS-CoV-2 infection (N 2,597,856), hospitalized 2,095,324), critical 1,086,211). Literature-based analysis was used build gene-based pathways connecting ADHD COVID-19. Results positively correlated with (R g : 0.22 ~ 0.30). Our Mendelian randomization (MR) analyses found that confers a causal effect on (odds ratio (OR): 1.36, 95% confidence interval (CI): 1.10–1.69). TS (OR: 1.14, CI: 1.04–1.25). Genetic liability may not increase risk for Pathway identified several immunity-related genes link COVID-19, including CRP , OXT IL6 PON1 AR TNFSF12 IL10 . Conclusions study suggests augment severity through pathways. However, our results did support role in

Language: Английский

Citations

8
Knowledge mapping of COVID-19 and autoimmune diseases: a visual and bibliometric analysis DOI Creative Commons

Youao Zhang,

Zixuan Jia,

Xia Xu

et al.

Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 23(7), P. 3549 - 3564

Published: July 3, 2023

Abstract Background Many studies have shown an association between COVID-19 and autoimmune diseases (ADs). Studies on ADs also increased significantly, but there is no bibliometric analysis to summarize the ADs. The purpose of this study was perform a visual published related Methods Based Web Science Core Collection SCI-Expanded database, we utilize Excel 2019 visualization tools Co-Occurrence13.2 (COOC13.2), VOSviewer, CiteSpace, HistCite for analysis. Results A total 1736 kinds papers were included, number presented overall increasing trend. country/region with most publications USA, institution Harvard Medical School, author Yehuda Shoenfeld from Israel, journal Frontiers in Immunology . Research hotspots include immune responses (such as cytokines storm), multisystem systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis), treatment modalities hydroxychloroquine, rituximab), vaccination mechanisms autoantibodies, molecular mimicry). future research direction may be ideas NF-κB, hyperinflammation, antiphospholipid antibodies, neutrophil extracellular traps, granulocyte-macrophage colony-stimulating factor), other cross-diseases inflammatory bowel disease, chronic mucocutaneous candidiasis, acute respiratory distress syndrome). Conclusion growth rate regarding has risen sharply. Our results can help researchers grasp current status find new directions future.

Language: Английский

Citations

7
Causal association between multiple sclerosis and severe COVID-19: A bidirectional Mendelian randomization study DOI
Shuangjie Li, Dongren Sun, Rui Wang

et al.

Journal of Neuroimmunology, Journal Year: 2024, Volume and Issue: 391, P. 578352 - 578352

Published: April 30, 2024

Language: Английский

Citations

2
COVID-19 and the risk of neuromyelitis optica spectrum disorder: a Mendelian randomization study DOI Creative Commons
Dongren Sun,

Qin Du,

Rui Wang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 27, 2023

Background An increasing number of studies have elucidated a close nexus between COVID-19 phenotypes and neuromyelitis optica spectrum disorder (NMOSD), yet the causality them remains enigmatic. Methods In this study, we conducted Mendelian randomization (MR) analysis employing summary data sourced from genome-wide association (GWAS) pertaining to susceptibility, hospitalization, severity, NMOSD. The primary MR employed Inverse variance weighted (IVW) approach, which was supplemented by MR-Egger, median, simple mode, mode methods. We implemented various sensitivity analyses including Cochran’s Q test, MR-PRESSO method, MR-Egger intercept, leave-one-out analysis, funnel plot. Results results demonstrated nominal susceptibility risk AQP4+ NMOSD, as evidenced IVW method (OR = 4.958; 95% CI: 1.322-18.585; P 0.018). Conversely, no causal observed or severity increased AQP4-NMOSD, comprehensive further bolstered robustness consistency estimates. Conclusion Our findings provide compelling evidence for effect phenotype on shedding new light understanding comorbidity

Language: Английский

Citations

6
Association between COVID‐19 and myasthenia gravis (MG): A genetic correlation and Mendelian randomization study DOI Creative Commons
Dongren Sun,

Liangdan Tu,

Xiaofei Wang

et al.

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(11)

Published: Aug. 28, 2023

Abstract Background: Observational studies have suggested an association between coronavirus disease 2019 (COVID‐19) and myasthenia gravis (MG). Here, we aimed to estimate the genetic correlation causal relationship COVID‐19 susceptibility, hospitalization, severity, MG phenotypes using linkage disequilibrium score regression (LDSC) Mendelian randomization (MR) approach. Methods Summary statistics of severity were used as instrumental variables for exposure traits. Large‐scale genome‐wide study (GWAS) data outcome The inverse variance weighted approach was main MR analysis, complemented by MR‐Egger, median, simple mode, mode methods. Sensitivity analysis implemented Cochran's Q test, MR‐PRESSO method, MR‐Egger intercept test. Results LDSC did not reveal any among phenotypes, including MG, early‐onset late‐onset ( p > .05). Our provide evidence supporting a effect or on Extensive sensitivity strengthened robustness consistency estimates. Conclusion find MG. Future with more GWAS are needed evaluate its subgroups.

Language: Английский

Citations

5
Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study DOI
Pingjian Ding, Rong Xu

Journal of the Neurological Sciences, Journal Year: 2023, Volume and Issue: 454, P. 120864 - 120864

Published: Oct. 31, 2023

Language: Английский

Citations

3
Pleiotropic Bias and Study Design Considerations in Genetic Association Studies DOI Creative Commons
Sana Eybpoosh, Seyyed Amir Yasin Ahmadi

Medical Journal of the Islamic Republic of Iran, Journal Year: 2024, Volume and Issue: unknown

Published: April 20, 2024

Background: Case-control studies are efficient designs for investigating gene-disease associations.A discovery of genome-wide association (GWAS) is that many genetic variants associated with multiple health outcomes and diseases, a phenomenon known as pleiotropy.We aimed to discuss about pleiotropic bias in studies.Methods: The opinions the researchers on basis literature were presented critical review.Results: Pleiotropic effect can results if they use individuals pre-existing diseases control group, while disease cases controls have shared markers.The idea supports conclusion when exposure interest case-control study marker, from diseased share similar markers may increase risk effect.However, not manifesting symptoms among at time recruitment does guarantee individual will develop future.Age-matched disease-free be better solution situations.Different analytical techniques also available used identify effects.Known effects searched various online databases.Conclusion: result studies.Suggestions consist selecting healthy yet agematched considering independent architecture.Checking related databases recommended before designing study.

Language: Английский

Citations

0
Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study DOI Creative Commons
Zirui Wang, Siqi Wang, Haonan Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37193 - e37193

Published: Aug. 30, 2024

Language: Английский

Citations

0