Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 163, P. 107191 - 107191

Published: June 20, 2023

Language: Английский

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The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 25, 2023

Over three years’ pandemic of 2019 novel coronavirus disease (COVID-19), multiple variants and subvariants have emerged successively, outcompeted earlier become predominant. The sequential emergence reflects the evolutionary process mutation-selection-adaption severe acute respiratory syndrome 2 (SARS-CoV-2). Amino acid substitution/insertion/deletion in spike protein causes altered viral antigenicity, transmissibility, pathogenicity SARS-CoV-2. Early pandemic, D614G mutation conferred virus with advantages over previous increased it also laid a conservative background for subsequent substantial mutations. role genomic recombination evolution SARS-CoV-2 raised increasing concern occurrence recombinants such as Deltacron, XBB.1.5, XBB.1.9.1, XBB.1.16 late phase pandemic. Co-circulation different co-infection immunocompromised patients accelerate recombinants. Surveillance variations, particularly recombination, is essential to identify ongoing changes genome antigenic epitopes thus leads development new vaccine strategies interventions.

Language: Английский

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Seroprevalence of SARS-CoV-2 infection among hospitalized children at a tertiary care center in North-East India

Journal of Tropical Pediatrics, Journal Year: 2025, Volume and Issue: 71(2)

Published: Jan. 31, 2025

Abstract To estimate the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection among hospitalized children aged between 1 and 12 years. A cross-sectional study was conducted to determine SARS-CoV-2 antibodies at a tertiary care hospital in North-East region India for period 13 months (October 2022–November 2023). The presence estimated using enzyme-linked immunosorbent assay method. Sociodemographic characteristics clinical profile participants were analyzed. years be 98.4%. This comparable age groups 1–5 (97.9%) 6–12 (99.1%) (P-value = .478). most commonly reported symptoms seropositive fever (76.8%), nasal stuffiness (69.5%), cough (67.8%), diarrhea (23.6%), nausea/vomiting (23.2%). None had prior history laboratory confirmed coronavirus disease (COVID-19) past none vaccinated against COVID-19. Results univariate analysis showed that there no significant difference seronegative distribution sociodemographic characteristics, profile, findings. Our observed remarkably high anti-SARS-CoV-2 seropositivity rate 98.4%, suggesting under-recognized burden COVID-19 pediatric population. findings highlight need continued preventive measures development age-appropriate vaccination strategies, particularly tropical settings.

Language: Английский

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PDE5 inhibitors: breaking new grounds in the treatment of COVID-19

Drug Metabolism and Personalized Therapy, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 23, 2023

Despite the ever-increasing occurrences of coronavirus disease (COVID-19) cases around world, very few medications have been validated in clinical trials to combat COVID-19. Although several vaccines developed past quarter, time elapsed between deployment and administration remains a major impediment.Repurposing pre-approved drugs, such as phosphodiesterase 5 (PDE5) inhibitors, could be game-changer while lessening burden on current healthcare system. Repurposing developing inhibitors extrapolate their utility SARS-CoV-2 infection, potentially aid management symptoms associated with its newer variants BF.7, BQ.1, BQ.1.1, XBB.1.5, XBB.1.16.Administration PDE5 via oral intravenous route demonstrates other potential off-label benefits, including anti-apoptotic, anti-inflammatory, antioxidant, immunomodulatory effects, by intercepting pathways. These effects can not only importance mild-to-moderate, but also moderate-to-severe infections. This article explores various mechanisms which alleviates COVID-19 well highlights recent studies findings.These benefits make it drug physicians' armamentarium alleviating infection. However, adequate must instituted eliminate any untoward adverse events.

Language: Английский

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Medicinal Plant Extracts and Herbal Formulations: Plant Solutions for the Prevention and Treatment of COVID-19 Infection

Future Integrative Medicine, Journal Year: 2023, Volume and Issue: 2(4), P. 216 - 226

Published: Dec. 25, 2023

The highly valued area of traditional medicine includes medicinal plants and the chemical compounds found in them that have therapeutic potential as effective remedies for a variety health issues. However, with respect to their active value, many from various environments fall under category being underexplored. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), was initially presented November 2019. It eventually labeled pandemic, an alarming number deaths (6.987 million) still active. Alternative therapies are receiving more attention means improving immunity managing symptoms over long term, despite well-established scientific community’s quick success implementing COVID-19 vaccinations. As alternative strategy management, comprise extracts, formulations, bioactive metabolites currently much interest. usefulness these herbal interventions manage infection has been subject recent studies, discussed here. In conclusion, we propose using plant extracts formulations approach treat COVID-19. This review may also instigate development anti-SARS-CoV-2 prophylactics phytochemicals extracts.

Language: Английский

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PDE5 inhibitors: breaking new grounds in the treatment of COVID-19

Drug Metabolism and Personalized Therapy, Journal Year: 2023, Volume and Issue: 38(4), P. 295 - 307

Published: Aug. 24, 2023

Abstract Introduction Despite the ever-increasing occurrences of coronavirus disease (COVID-19) cases around world, very few medications have been validated in clinical trials to combat COVID-19. Although several vaccines developed past quarter, time elapsed between deployment and administration remains a major impediment. Content Repurposing pre-approved drugs, such as phosphodiesterase 5 (PDE5) inhibitors, could be game-changer while lessening burden on current healthcare system. developing inhibitors extrapolate their utility SARS-CoV-2 infection, potentially aid management symptoms associated with its newer variants BF.7, BQ.1, BQ.1.1, XBB.1.5, XBB.1.16. Summary Administration PDE5 via oral intravenous route demonstrates other potential off-label benefits, including anti-apoptotic, anti-inflammatory, antioxidant, immunomodulatory effects, by intercepting pathways. These effects can not only importance mild-to-moderate, but also moderate-to-severe infections. This article explores various mechanisms which alleviates COVID-19 well highlights recent studies findings. Outlook benefits make it drug physicians’ armamentarium alleviating infection. However, adequate must instituted eliminate any untoward adverse events.

Language: Английский

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Current Progress in Genomic and Genetic Research on Human Viral Diseases

Frontiers research topics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

it is a pioneering approach to the world of academia, radically improving way scholarly research managed.The grand vision Frontiers where all people have an equal opportunity seek, share and generate knowledge.Frontiers provides immediate permanent online open access its publications, but this alone not enough realize our goals. journal seriesThe series multi-tier interdisciplinary set openaccess, journals, promising paradigm shift from current review, selection dissemination processes in academic publishing.All journals are driven by researchers for researchers; therefore, they constitute service community.At same time, operates on revolutionary invention, tiered publishing system, initially addressing specific communities scholars, gradually climbing up broader public understanding, thus serving interests lay society, too. Dedication qualityEach article landmark highest quality, thanks genuinely collaborative interactions between authors review editors, who include some world's best academicians.Research must be certified peers before entering stream knowledge that may eventually reach -and shape society; only applies most rigorous unbiased reviews.Frontiers revolutionizes freely delivering outstanding research, evaluated with no bias both social point view.By applying advanced information technologies, catapulting into new generation.

Language: Английский

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