Deciphering the role of HPV-mediated metabolic regulation in shaping the tumor microenvironment and its implications for immunotherapy in HNSCC DOI Creative Commons

Xiangjin Gong,

Jingwen Xiong,

Yu Gong

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 9, 2023

Head and neck squamous cell carcinoma (HNSCC), as a complex variable malignancy, poses significant threat to human health. Since the intricate association between HPV HNSCC emerged, its role within TME has garnered extensive attention. HPV+HNSCC exhibits distinct immunological characteristics TME, intricately intertwined with mechanisms of immune evasion. employs multifaceted pathways intervene in metabolic regulation exerting influence over functionality neoplastic genesis. Furthermore, heightened reactivity exhibited by augments responses interventions such checkpoint inhibitors. Therefore, amidst current limitations therapeutic approaches, immunotherapy stands promising strategy overcome conventional confines treating HNSCC. This article comprehensively outlines impact on inception progression while discussing amalgamation immunotherapeutic strategies. By intervening reciprocal interactions potential modulate efficacy immune-based treatments becomes evident. Concurrently, synthesis pertinent biomarker development is summarized. Such endeavors hold paramount significance for personalized approaches more effective management patients.

Language: Английский

Deciphering Treg cell roles in esophageal squamous cell carcinoma: a comprehensive prognostic and immunotherapeutic analysis DOI Creative Commons
Pengpeng Zhang, Shiyang Dong, Wei Sun

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 28, 2023

Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive form of cancer that poses significant challenges in terms prognosis treatment. Regulatory T cells (Treg cells) have gained attention due to their influential role immune modulation within the tumor microenvironment (TME). Understanding intricate interactions between Treg essential for unraveling mechanisms underlying ESCC progression developing effective prognostic models immunotherapeutic strategies. Methods: A combination single-cell RNA sequencing (scRNA-seq) bulk RNA-seq analysis was utilized explore TME ESCC. The accuracy applicability model were assessed through multi-dimensional evaluations, encompassing an examination model's performance across various dimensions, such as mutation landscape, clinical relevance, enrichment analysis, potential implications immunotherapy Results: pivotal macrophage migration inhibitory factor (MIF) signaling pathway investigated, with focus on its impact other subpopulations. Through comprehensive integration data, Treg-associated signature (TAS) constructed, revealing patients elevated TAS (referred high-TAS individuals) experienced significantly improved prognoses. Heightened infiltration increased expression checkpoint markers observed specimens. validity established IMvigor210 dataset, demonstrating robustness predicting responsiveness immunotherapy. therapeutic benefits immune-based interventions patients. Noteworthy differences patterns emerged high low-TAS cohorts, highlighting avenues exploration. Furthermore, relevance key genes substantiated by analyzing samples from ten paired adjacent tissues, differential levels. Conclusion: study enables accurate prediction patient This achievement holds management ESCC, offering valuable insights informed interventions.

Language: Английский

Citations

25
The integrated single-cell analysis developed an immunogenic cell death signature to predict lung adenocarcinoma prognosis and immunotherapy DOI Creative Commons
Pengpeng Zhang, Haotian Zhang, Junjie Tang

et al.

Aging, Journal Year: 2023, Volume and Issue: 15(19), P. 10305 - 10329

Published: Oct. 4, 2023

Background: Research on immunogenic cell death (ICD) in lung adenocarcinoma (LUAD) has been relatively limited. This study aims to create ICD-related signatures for accurate survival prognosis prediction LUAD patients, addressing the challenge of lacking reliable early prognostic indicators this type cancer. Methods: Using single-cell RNA sequencing (scRNA-seq) analysis, ICD activity cells was calculated by AUCell algorithm, divided into high- and low-ICD groups according median values, key regulatory genes were identified through differential these integrated TCGA data construct using LASSO COX regression multi-dimensional analysis terms prognosis, immunotherapy, tumor microenvironment (TME), mutational landscape. Results: The constructed signature reveals a pronounced disparity between low-risk patients. statistical discrepancies times among patients from both GEO databases further corroborate observation. Additionally, heightened levels immune infiltration expression are evidenced group, suggesting potential benefit immunotherapeutic interventions pivotal risk-associated tissue samples assessed utilizing qRT-PCR, thereby unveiling PITX3 as plausible therapeutic target context LUAD. Conclusions: Our provide help predicting immunotherapy some extent guide clinical treatment

Language: Английский

Citations

23
Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms DOI Creative Commons

Emad Heydarnia,

Zahra Dorostgou,

Neda Hedayati

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 10, 2024

Abstract Cervical cancer (CC) is a common gynecologic malignancy, accounting for significant proportion of women death worldwide. Human papillomavirus (HPV) infection one the major etiological causes leading to CC onset; however, genetic, and epigenetic factors are also responsible disease expansion. Circular RNAs (circRNAs), which known as particular subset non-coding RNA (ncRNA) superfamily, with covalently closed loop structures, have been reported be involved in progression diverse diseases, especially neoplasms. In this framework, abnormally expressed circRNAs strong correlation pathogenesis through regulating substantial signaling pathways. Also, these molecules can considered promising biomarkers therapeutic targets diagnosis/prognosis treatment, respectively. Herein, we first review key molecular mechanisms, including Wnt/β-catenin, MAPK, PI3K/Akt/mTOR pathways, well angiogenesis metastasis, by interfere development. Then, diagnostic, prognostic, potentials ncRNA will highlighted depth.

Language: Английский

Citations

13
The potential use of therapeutics and prophylactic mRNA vaccines in human papillomavirus (HPV) DOI Creative Commons

Fatemeh Movahed,

Satinik Darzi,

Parya Mahdavi

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 31, 2024

Abstract Cervical cancer (CC) and other malignant malignancies are acknowledged to be primarily caused by persistent human papillomavirus (HPV) infection. Historically, vaccinations against viruses that produce neutralizing antibodies unique the virus have been an affordable way manage viral diseases. CC risk is decreased, but not eliminated, HPV vaccinations. Since made available globally, almost 90% of infections successfully avoided. On lesions diseases already present, however, no discernible treatment benefit has shown. As a result, therapeutic vaccines elicit immune responses mediated cells necessary for established cancers. mRNA possess remarkable potential in combating malignancy as result their superior industrial production, safety, efficacy. Furthermore, considering expeditiousness vaccine exhibits promise approach targeting HPV. Given HPV-encoded early proteins, including oncoproteins E6 E7, consistently present HPV-related cancers pre-cancerous crucial functions progression persistence diseases, they serve ideal targets vaccines. The action mechanism vaccines, recent advancements clinical trials, applications highlighted this study, which also offers quick summary state Lastly, we highlight few difficulties with vaccination practice provide our thoughts on further quickly changing sector. It expected will soon produced prevention treatment. Graphical

Language: Английский

Citations

12
Unveiling the intratumoral microbiota within cancer landscapes DOI Creative Commons
Shusheng Che, Zhiyong Yan, Yugong Feng

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893

Published: May 3, 2024

Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.

Language: Английский

Citations

9
Recent update on the Development of HPV16 inhibitors for Cervical Cancer DOI
Muhammad Shoaib, Amina Tariq, Yanchen Liu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104703 - 104703

Published: March 1, 2025

Language: Английский

Citations

1
Revealing the role of regulatory T cells in the tumor microenvironment of lung adenocarcinoma: a novel prognostic and immunotherapeutic signature DOI Creative Commons
Pengpeng Zhang, Xiao Zhang, Yanan Cui

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 21, 2023

Regulatory T cells (Tregs), are a key class of cell types in the immune system. In tumor microenvironment (TME), presence Tregs has important implications for response and development. Relatively little is known about role lung adenocarcinoma (LUAD).Tregs were identified using but single-cell RNA sequencing (scRNA-seq) analysis interactions between other TME investigated. Next, we used multiple bulk RNA-seq datasets to construct risk models based on marker genes explored differences prognosis, mutational landscape, infiltration immunotherapy high- low-risk groups, finally, qRT-PCR function experiments performed validate model genes.The cellchat showed that MIF-(CD74+CXCR4) pairs play interaction with subpopulations, Tregs-associated signatures (TRAS) could well classify LUAD cohorts into groups. Immunotherapy may offer greater potential benefits group, as indicated by their superior survival, increased cells, heightened expression checkpoints. Finally, experiment verified LTB PTTG1 relatively highly expressed cancer tissues, while PTPRC was paracancerous tissues. Colony Formation assay confirmed knockdown reduced proliferation ability cells.TRAS constructed scRNA-seq distinguish patient subgroups, which provide assistance clinical management patients.

Language: Английский

Citations

21
mRNA‐HPV vaccine encoding E6 and E7 improves therapeutic potential for HPV‐mediated cancers via subcutaneous immunization DOI
Seonghyun Lee, Hyunho Yoon,

Seol Hee Hong

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(12)

Published: Dec. 1, 2023

Abstract The E6 and E7 proteins of specific subtypes human papillomavirus (HPV), including HPV 16 18, are highly associated with cervical cancer as they modulate cell cycle regulation. aim this study was to investigate the potential antitumor effects a messenger RNA‐HPV therapeutic vaccine (mHTV) containing nononcogenic proteins. To achieve this, C57BL/6j mice were injected via both intramuscular subcutaneous routes, resulting evaluated. mHTV immunization markedly induced robust T cell‐mediated immune responses significantly suppressed tumor growth in orthotopic tumor‐implanted mouse model, significant infiltration cells into tissues. Tumor retransplantation at day 62 postprimary vaccination completely halted progression all mHTV‐treated mice. Furthermore, expansion reduced upon TC‐1 transplantation 160 days after last immunization. Immunization rhesus monkeys elicited promising responses. immunogenicity nonhuman primates provides strong evidence for clinical application against HPV‐related cancers humans. All data suggest that can be used prophylactic vaccine.

Language: Английский

Citations

13
Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM DOI Creative Commons

Dongyun Rong,

Yushen Su,

Dechao Jia

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Skin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and immunotherapy being among the most common cancer treatment modalities. This study aims to identify novel biomarkers for response in SKCM explore their association oxidative stress.

Language: Английский

Citations

5
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy DOI

Bicheng Ye,

Aimin Jiang, Liang Feng

et al.

BioFactors, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Immunotherapy has revolutionized cancer treatment; however, predicting patient response remains a significant challenge. Our study identified novel plasma cell signature, Plasma cell.Sig, through pan‐cancer single‐cell RNA sequencing analysis, which predicts outcomes to immunotherapy with remarkable accuracy. The signature was developed using rigorous machine learning algorithms and validated across multiple cohorts, demonstrating superior predictive power an area under the curve (AUC) exceeding 0.7. Notably, low‐risk group, as classified by exhibited enriched immune infiltration heightened tumor immunogenicity, indicating enhanced responsiveness immunotherapy. Conversely, high‐risk group showed reduced activity potential mechanisms of evasion. These findings not only enhance understanding intrinsic extrinsic landscapes within microenvironment but also pave way for more precise, biomarker‐guided approaches in oncology.

Language: Английский

Citations

5