The Impact of Oral Microbiome Dysbiosis on the Aetiology, Pathogenesis, and Development of Oral Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997

Published: Aug. 28, 2024

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.

Language: Английский

---

Emerging roles of intratumor microbiota in cancer: tumorigenesis and management strategies

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 11, 2024

Language: Английский

---

Revisiting the role of cancer-associated fibroblasts in tumor microenvironment

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Cancer-associated fibroblasts (CAFs) are integral components of the tumor microenvironment playing key roles in progression, metastasis, and therapeutic resistance. However, challenges persist understanding their heterogeneity, origin, functional diversity. One major obstacle is lack standardized naming conventions for CAF subpopulations, with current systems failing to capture full complexity. Additionally, identification CAFs hindered by absence specific biomarkers, limiting precision diagnostic strategies. In vitro culture conditions often fail maintain vivo characteristics CAFs, which complicates study translation findings clinical practice. Although detection methods, such as antibodies, mRNA probes, single-cell transcriptomics, offer insights into biology, they standardization provide reliable quantitative measures. Furthermore, dynamic interactions between cells, immune cells within TME remain insufficiently understood, role evasion therapy resistance an area ongoing research. Understanding how influence drug response essential developing more effective cancer therapies. This review aims in-depth analysis research, propose future research directions, emphasize need improved CAF-targeted By addressing these gaps, it seeks highlight potential targets overcoming enhancing efficacy treatments.

Language: Английский

---

The cancer microbiome

Advances in clinical chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105708 - 105708

Published: April 22, 2025

Language: Английский

---

Fusobacterium nucleatum: a novel regulator of antitumor immune checkpoint blockade therapy in colorectal cancer

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 3962 - 3975

Published: Jan. 1, 2024

Neoadjuvant immune checkpoint blockade (ICB) has achieved significant success in treating various cancers, leading to improved therapeutic responses and survival rates among patients. However, colorectal cancer (CRC), ICB yielded poor results tumors that are mismatch repair proficient, microsatellite-stable, or have low levels of microsatellite instability (MSI-L), which account for up 95% CRC cases. The underlying mechanisms behind the lack response MSI-negative inhibitors remain an open conundrum. Consequently, there is urgent need explore intrinsic related biomarkers enhance intratumoral render tumor "immune-reactive". Intestinal microbes, such as oral microbiome member Fusobacterium nucleatum (

Language: Английский

---

Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 29, 2024

The concept of intratumoral microbiota is gaining attention in current research. Tumor-associated can activate oncogenic signaling pathways such as NF-κB, thereby promoting tumor development and progression. Numerous studies have demonstrated that curcumin its analogs possess strong antitumor effects by targeting the NF-κB pathway, along with potent antibacterial properties. In this study, we tested activity two curcuminoids, Py-cPen V-cPen, against Gram-negative bacterial strains

Language: Английский

---

Mechanistic and epidemiological evidence on the relationship between microbiota, virome and carcinogenesis

Advances in molecular oncology, Journal Year: 2024, Volume and Issue: 11(4), P. 8 - 22

Published: Dec. 9, 2024

Recent development of molecular and genetic technologies has demonstrated at the level co-evolutionary principles interaction between microbiota, virome host organism, as well role microorganisms viruses both in maintaining physiological homeostasis various diseases, including malignant neoplasms. The presented review is devoted to analysis generalization modern data on inhabiting human body, their processes initiation, promotion progression carcinogenesis. provides information known oncogenic according classification carcinogenic agents International Agency for Research Cancer. Mechanistic procarcinogenic effect microbiota are considered accordance with concept key characteristics a agent. Particular attention paid influence immunity first results immunotherapy Coley toxin soft tissue sarcomas osteosarcomas, individual types formation immunocompetent cell profile organism. In addition, intratumor intracellular respectively, microenvironment tumor cells cellular signaling, solid tumors that have no contact external environment also discussed. important terms holobiota concept, showing interdependent existence viruses, improve prevention therapy

Language: Английский

---

Effect of Gut Dysbiosis on Onset of GI Cancer

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 90 - 90

Published: Dec. 30, 2024

Dysbiosis in the gut microbiota plays a significant role GI cancer development by influencing immune function and disrupting metabolic functions. can drive carcinogenesis through pathways like dysregulation release of carcinogenic metabolites, altered metabolism, genetic instability, pro-inflammatory signalling, contributing to initiation progression. Helicobacter pylori infection genotoxins released from dysbiosis, lifestyle dietary habits are other factors that contribute development. Emerging diagnostic therapeutic approaches show promise colorectal treatment, including multitarget faecal immunochemical test (mtFIT), standard FIT, transplantation (FMT) combined with PD-1 inhibitors. We used search engine databases PubMed, Scopus, Web Science. This review discusses dysbiosis onset explores strategies such as FMT, probiotics, prebiotics enhance response improve therapy outcomes.

Language: Английский

---