Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 22, 2024

Abstract Periodontitis is closely related to inflammatory bowel disease (IBD). An excessive and non-self-limiting immune response the dysbiotic microbiome characterizes two. However, underlying mechanisms that overlap still need be clarified. We demonstrate critical periodontal pathogen Porphyromonas gingivalis (Pg) aggravates intestinal inflammation Th17/Treg cell imbalance in a gut microbiota-dependent manner. Specifically, metagenomic metabolomic analyses shows oral administration of Pg increases levels Bacteroides phylum but decreases Firmicutes , Verrucomicrobia Actinobacteria phyla. Nevertheless, it suppresses linoleic acid (LA) pathway microbiota, which was target metabolite determines degree functions as an aryl hydrocarbon receptor (AHR) ligand suppress Th17 differentiation while promoting Treg via phosphorylation Stat1 at Ser727. Therapeutically restoring LA colitis mice challenged with exerts anti-colitis effects by decreasing ratio AHR-dependent Our study suggests microbiota-LA metabolism-Th17/Treg balance axis, providing potential therapeutically modifiable for IBD patients periodontitis.

Language: Английский

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Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 28, 2023

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that demonstrates dramatically increasing incidence worldwide. This study provides novel insights into capacity exogenous β-hydroxybutyrate and ketogenic diet (KD) consumption to alleviate dextran sodium sulfate (DSS)-induced UC in rats. Remarkably, both interventions attenuated activity colon weight-to-length ratio, improved macro microstructures damaged colon. Importantly, KD curbed DSS-induced aberrant NLRP3 inflammasome activation as observed mRNA protein expression analysis. Additionally, inhibition NLRP3/NGSDMD-mediated pyroptosis was detected response regimens. In parallel, these modalities caspase-1 its associated consequences IL-1β IL-18 overproduction. They also mitigated apoptosis indicated by inactivation caspase-3. The anti-inflammatory effects BHB were confirmed reported decline levels markers including MPO, NFκB, IL-6, TNF-α. Moreover, exhibited antioxidative properties reducing ROS production improving enzymes. Their effectiveness mitigating evident renovation normal intestinal epithelial barrier function, shown correcting discrepancies tight junction proteins ZO-1, OCLN, CLDN5. Furthermore, their on microbiota homeostasis investigated. terms autophagy, upregulated BECN-1 downregulated p62, which may account for superiority over attenuating colonic damage. conclusion, this experimental evidence supporting potential therapeutic use or β-hydroxybutyrate-boosting regimens UC.

Language: Английский

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Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

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Unravelling the Oral–Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective

Journal of Crohn s and Colitis, Journal Year: 2024, Volume and Issue: 18(8), P. 1319 - 1341

Published: Feb. 28, 2024

As the opposite ends of orodigestive tract, oral cavity and intestine share anatomical, microbial, immunological ties that have bidirectional health implications. A growing body evidence suggests an interconnection between pathologies inflammatory bowel disease [IBD], implying a shift from traditional concept independent diseases to complex, reciprocal cycle. This review outlines supporting 'oral-gut' axis, marked by higher prevalence periodontitis other conditions in IBD patients vice versa. We present in-depth examination IBD, highlighting shared microbiological pathways, proposing 'multi-hit' hypothesis pathogenesis periodontitis-mediated intestinal inflammation. Furthermore, underscores critical need for collaborative approach dentists gastroenterologists provide holistic oral-systemic healthcare.

Language: Английский

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Bidirectional associations between periodontitis and inflammatory bowel disease: A systematic review of longitudinal studies with meta‐analysis and trial sequential analysis

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: 59(6), P. 1083 - 1094

Published: June 4, 2024

Abstract The bidirectional associations between periodontitis and inflammatory bowel disease (IBD) with temporal directionality remain inconclusive. This study aims to evaluate the IBD through a systematic review meta‐analysis. Five databases (PubMed, Embase, Web of Science, Scopus Cochrane Library) were systematically searched from inception 27 February 2024. Two independent reviewers performed retrieved studies. Longitudinal studies, including cohort nested case–control considered eligible for design. pooled risk ratio (RR) hazard (HR) derived meta‐analysis used assess whether (or IBD) was factor periodontitis). Trial sequential analysis (TSA) reliability results. Four studies ( n = 10 270 912) on in patients two 33 420) included. result suggested that did not increase (pooled RR 1.04, 95% confidence interval [CI]: 0.99–1.09; p .164; I‐squared statistic [ I 2 ] 27%). For subtypes IBD, associated occurrence ulcerative colitis (UC) 1.12, CI: 1.04–1.21; .003; 38%), but Crohn's (CD) 0.98, 0.92–1.04; .475; 0%). Specifically, UC higher among men HR 1.11, 1.01–1.22; .025; 0%) smokers 1.23, 1.07–1.42; .004; than their counterparts without periodontitis. Patients may have developing 1.37, 1.26–1.49; < .001; 18%); however, increased remained uncertain. TSA results confirmed primary findings. Based limited longitudinal evidence, do exhibit an overall, they are at (not CD). On contrary, over time. More high‐quality needed determine effect specific

Language: Английский

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Oral–Gut Microbiota, Periodontal Diseases, and Arthritis: Literature Overview on the Role of Probiotics

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4626 - 4626

Published: Feb. 27, 2023

Periodontal diseases are oral inflammatory affecting the tissues supporting and surrounding teeth include gingivitis periodontitis. Oral pathogens may lead to microbial products spreading into systemic circulation reaching distant organs, while periodontal have been related low-grade inflammation. Gut microbiota alterations might play a role in pathogenesis of several autoimmune including arthritis, considering gut–joint axis regulation molecular pathways involved these conditions. In this scenario, it is hypothesized that probiotics contribute intestinal micro-ecological balance could reduce inflammation typical arthritis. This literature overview aims summarize state-of-the-art ideas about linkages among oral–gut microbiota, diseases, investigating as potential therapeutic intervention for management both musculoskeletal disorders.

Language: Английский

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Pretreatment with Bifidobacterium longum BAA2573 ameliorates dextran sulfate sodium (DSS)-induced colitis by modulating gut microbiota

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 6, 2023

Objectives Inflammatory bowel disease (IBD) is a chronic lifelong inflammatory disease. Probiotics such as Bifidobacterium longum are considered to be beneficial the recovery of intestinal inflammation by interaction with gut microbiota. Our goals were define effect exclusive use BAA2573 on dextran sulfate sodium (DSS)-induced colitis, including improvement symptoms, alleviation histopathological damage, and modulation Methods In present study, we pretreated C57BL/6J mice BAA2573, one main components in an over-the-counter (OTC) probiotic mixture BIFOTO capsule, before modeling DSS. 16S rDNA sequencing liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based non-targeted metabolomic profiling performed collected feces. Results We found that pretreatment given gavage significantly improved symptoms damage DSS-induced colitis mice. After intervention, 57 genera 39 metabolites altered. Pathway enrichment analysis demonstrated starch sucrose metabolism, vitamin B6 sphingolipid metabolism may contribute ameliorating colitis. Moreover, revealed microbiome interrelated intervention group, while Alistipes was core genus. Conclusion study demonstrates impact microbiota reveals possible novel adjuvant therapy for IBD patients.

Language: Английский

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Dental problems and oral microbiome alterations in ulcerative colitis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Ulcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis been recently highlighted. Overall, microbiome alterations concern the reduction bacterial abundance and diversity, resulting gut imbalance negatively affecting immunological aspects. There link between ulcerative oral microbiome. changes are found at many levels, from gently dysbiotic composition to presence main periodontal microbes. analysis can be part personalized medicine due fact it potential biomarker. Patients with may manifest dental symptoms/problems, such as periodontitis (strongly related red-complex pathogens— Porphyromonas gingivalis , Tannerella forsythia Treponema denticola bacteria belonging other complexes, Fusobacterium nucleatum Aggregatibacter actinomycetecomitans ), caries, ulcerations, leukoplakia, halitosis, others. Notably, DMFT (Decayed, Missing, Filled Teeth) index higher these patients compared healthy subjects. According some data, lichen planus (which an background) also observed patients. It seems deep understanding association microbiome, immunology, manifestations crucial provide complex treatment point view.

Language: Английский

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Complete genome and transcriptome datasets of Streptococcus salivarius strains from healthy Korean subjects

Scientific Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 19, 2025

The oral microbiome plays a crucial role in maintaining health, with Streptococcus salivarius recognized for its beneficial probiotic functions, including inhibiting pathogenic bacteria and supporting immune regulation, particularly healthy individuals. While research on S. has primarily focused strains originating from non-Asian populations, New Zealand, some studies also reporting European strains, Korea been notably lacking. This dataset provides the complete genome sequences transcriptomic profiles of 12 isolated Korean PacBio SMRTbell technology was employed sequencing. Our includes data that reveal functional gene expression patterns under standard growth conditions. analyzed here are valuable as each exhibits unique interaction Fusobacterium nucleatum, pathogen associated periodontal disease colorectal cancer, collectively demonstrating diverse interaction. By offering comprehensive strain variation, this resource can serve tool aimed at understanding utilizing bacteria.

Language: Английский

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Oral Fusobacterium nucleatum exacerbates ulcerative colitis via the oral-gut axis: mechanisms and therapeutic implications

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Fusobacterium nucleatum (F. nucleatum) is an anaerobic bacterium known for its association with periodontal disease and oral infections. It has been implicated in the development of gastrointestinal diseases such as inflammatory bowel colorectal cancer. Ulcerative colitis (UC), which characterized by chronic inflammation colon, a condition unknown etiology rising incidence rate, significantly affecting quality life patients. The increased intestinal permeability during UC may facilitate adherence or invasion F. into damaged barrier, leading to exacerbated inflammation. This article introduces concept oral-gut axis, reviewing existing literature analyze role pathogenesis exploring potential pathogenic mechanisms. also summarizes latest advances treating patients who have looks forward prospective therapeutic strategies translational prospects within axis. be key player UC, likely due invasiveness periods permeability. paper discusses innovative approaches prevention management nucleatum, paving way more effective treatment UC. review offers new insights complex relationship between microbiome diseases, enhancing our understanding their dynamic interactions. There paucity on approaches, indicating need further clinical research.

Language: Английский

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