Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 4471 - 4479
Published: Oct. 1, 2023
Peri-implantitis
is
an
important
cause
of
oral
implant
failure.
In
the
past,
TLR4
and
TLR2
in
Toll-like
family
were
generally
considered
as
key
immune
recognition
receptors
regulating
peri-implantitis.
However,
under
guidance
this
theory,
there
are
still
some
unexplainable
peri-implantitis
symptoms.
With
discovery
novel
intracellular
LPS
receptor
Caspase-11,
a
new
understanding
inflammatory
signaling
regulation
development
has
been
gained.
regulatory
role
Caspase-11
its
crosstalk
with
pathway
remain
unclear.
The
therapeutic
effect
drugs
targeting
on
early
stages.
view
situation,
paper
reviews
possible
peri-implant
inflammation,
elaborated
entry
process
activation
mechanism
analyzes
differences
between
commonly
studied
animals,
mice
humans.
current
research
hotspots
challenges
also
analyzed
to
provide
insights
ideas
for
researchers.
Journal of Periodontal Research,
Journal Year:
2024,
Volume and Issue:
59(4), P. 647 - 656
Published: April 26, 2024
Abstract
Aim
This
study
evaluated
the
efficacy
of
quadrantwise
subgingival
instrumentation
(Q‐SI)
versus
one‐stage
full‐mouth
(FM‐SI)
on
probing
depth
and
periodontal
pathogen
reduction
over
a
6‐month
follow‐up
period,
as
well
whether
baseline
pathogens
influenced
impact
treatment
protocols
outcomes.
Methods
Patients
with
periodontitis
were
randomized
to
receive
Q‐SI
(
n
=
43)
or
FM‐SI
45).
instructed
motivated
maintain
optimal
oral
hygiene
during
sessions.
Clinical
(probing
pocket
[PPD],
clinical
attachment
loss
[CAL],
bleeding
[BOP])
assessed
at
after
30,
90,
180
days.
Total
bacterial
load
analysed
via
real‐time
PCR.
Results
At
follow‐up,
median
PPD
decreased
from
4.8
mm
(interquartile
range
[IQR]:
4.3–5.2)
2.6
(IQR:
2.3–2.9)
in
patients
4.7
4.1–5.2)
3.2
2.4–3.5)
p
<
.001).
6
months,
was
more
effective
reducing
proportions
Porphyromonas
gingivalis
Pg
),
Aggregatibacter
actinocomyctemcomitans
,
Tannerella
forsythia
Tf
)
.001
for
each
value).
Multilevel
linear
regression
analysis
demonstrated
that
high
.029),
.014),
.001)
levels
protocol
statistically
significant
predictors
months.
Furthermore,
significantly
greater
group
when
lower
detected.
Conclusion
The
than
mean
number
period.
Higher
had
negative
months
FM‐SI.
Journal of Periodontology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 2, 2024
Growing
evidence
suggests
the
type
of
periodontal
treatment
could
differentially
influence
reduction
key
cardiovascular
risk
mediators
in
periodontitis
patients.
This
randomized,
controlled
clinical
trial
compared
impact
minimally
invasive
non-surgical
therapy
(MINST)
with
quadrant-wise
subgingival
instrumentation
(Q-SI)
on
C-reactive
protein
(CRP)
together
lipoprotein-associated
phospholipase
A
Periodontology 2000,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
To
provide
a
comprehensive
and
updated
mapping
of
observational
studies
assessing
the
relationship
between
periodontitis
systemic
diseases
through
bibliometric
visual
analysis.
A
search
was
conducted
using
Web
Science
database,
covering
period
1989
to
2024.
The
Medical
Subject
Headings
(MeSH)
from
US
National
Library
Medicine
used
categorize
conditions,
focusing
on
terms
unrelated
stomatognathic
diseases.
analysis
included
keyword
co‐occurrence
mapping,
co‐authorship,
bibliographic
coupling,
co‐citation
Quality
indicators
such
as
silhouette
score,
modularity,
centrality
were
considered
assess
network's
quality.
research
strategy
identified
6106
records,
which
1519
met
inclusion
criteria.
revealed
that
46.73%
literature
topic
published
in
last
5
years
annual
publication
trend
peaked
2023.
Nutritional
&
Metabolic
Diseases
(
n
=
398),
Cardiovascular
335),
Female
Urogenital
Pregnancy
Complications
244),
Musculoskeletal
182)
most
representative
categories
associated
with
periodontitis.
co‐cited
journals
Journal
Periodontology
1412),
Clinical
1343),
Dental
Research
940),
2000
849).
USA,
China,
Brazil,
Sweden
countries
contributed
number
publications.
present
study
growing
evaluating
association
diseases,
highlighting
negative
impact
plethora
conditions
rising
translational
interest
this
relationship.
With
an
aging
population,
is
expected
affect
people
coming
decades,
presenting
significant
challenges
public
health.
Improved
knowledge
is,
therefore,
essential
enable
more
care,
preventive
strategies,
optimal
oral
health
for
patients
Medicina,
Journal Year:
2024,
Volume and Issue:
60(5), P. 773 - 773
Published: May 7, 2024
The
regeneration
of
periodontal
bone
defects
continues
to
be
an
essential
therapeutic
concern
in
dental
biomaterials.
Numerous
biomaterials
have
been
utilized
this
sector
so
far.
However,
the
immune
response
and
vascularity
defect
regions
may
disregarded
when
evaluating
effectiveness
for
repair.
Among
several
regenerative
treatments,
most
recent
technique
situ
tissue
engineering
stands
out
its
ability
replicate
endogenous
restorative
processes
by
combining
scaffold
with
particular
growth
factors.
Regenerative
medicine
solutions
that
combine
biomaterials/scaffolds,
cells,
bioactive
substances
attracted
significant
interest,
particularly
repair
regeneration.
Dental
stem
cells
(DSCs)
share
same
progenitor
immunomodulatory
properties
as
other
types
MSCs,
because
they
are
easily
isolable,
regarded
desirable
agents
dentistry.
Recent
research
has
demonstrated
DSCs
sown
on
newly
designed
synthetic
bio-material
scaffolds
preserve
their
proliferative
capacity
while
exhibiting
increased
differentiation
immuno-suppressive
capabilities.
As
researchers
discovered
how
short
peptide
sequences
modify
adhesion
capacities
activating
or
inhibiting
conventional
osteogenic
pathways,
became
more
effective
at
priming
MSCs.
In
review,
many
components
applied
will
examined,
impact
cellular
biology/molecular
genetics
addressed
updated.
Journal of Periodontology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 16, 2024
Abstract
Background
To
assess
the
available
evidence
on
whether
nonsurgical
periodontal
treatment
(NSPT)
improves
arterial
stiffness
outcomes
in
patients
with
periodontitis
(PD).
Methods
Following
Preferred
Reporting
Items
for
Systematic
Reviews
and
Meta‐analyses
(PRISMA)
guidelines
population,
intervention,
comparison,
outcomes,
study
design
(PICOS)
question,
electronic
databases
were
screened
clinical
interventional
studies
addressing
impact
of
NSPT
pulse
wave
velocity
(PWV),
carotid
intima‐media
thickness
(CIMT),
flow‐mediated
dilatation
(FMD)
PD
patients.
Furthermore,
research
strategy
was
implemented
using
a
hand
search.
Studies
selected,
data
extracted
by
two
independent
reviewers.
Random
effects
models
applied
to
perform
meta‐analysis,
methodological
index
nonrandomized
(MINORS)
Cochrane
Rob2
tools
used
risk
bias.
Results
Fifteen
articles
finally
included
qualitative
synthesis.
Among
them,
eight
single‐arm
cohort
met
final
inclusion
criteria
meta‐analysis.
The
analysis
evidenced
that
one
randomized
trial
(RCT)
had
low
risk,
three
RCTs
raised
some
concerns,
high
bias,
while
MINORS
scores
ranged
from
9
14.
meta‐analysis
showed
significantly
impacted
FMD
(
p
<
0.001)
CIMT
=
0.004),
changes
PWV
not
statistically
significant.
However,
there
heterogeneity
among
I
2
78%
62%
CIMT).
Conclusion
Despite
beneficial
CIMT,
due
limitations,
heterogeneity,
it
cannot
be
concluded
is
effective
improving
stiffness.
Therefore,
further
are
necessary
achieve
high‐quality
effect
Trial
registration
PROSPERO
ID
CRD42024501399.
Plain
Language
Summary
Periodontitis
(PD)
has
been
associated
alterations
related
early
endothelial
dysfunction.
Based
noninterventional
studies,
this
indicates
may
reduce
cardiovascular
disease
PD.
moderate
derived
thickness,
trend
observed
velocity.
Moreover,
findings
present
characterized
bias
uncontrolled
trials
or
limitations.
more
standardized
protocols
homogeneous
needed
elevate
quality
evidence.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(8)
Published: April 1, 2024
Abstract
Autophagy
is
a
cellular
process
that
evolutionarily
conserved,
involving
the
sequestration
of
damaged
organelles
and
proteins
into
autophagic
vesicles,
which
subsequently
fuse
with
lysosomes
for
degradation.
controls
development
many
diseases
by
influencing
apoptosis,
inflammation,
immune
response
different
processes.
plays
significant
role
in
aetiology
disorders
associated
dentistry.
odontogenesis.
Furthermore,
it
implicated
pathophysiology
pulpitis
periapical
disorders.
It
enhances
survival,
penetration
colonization
periodontal
pathogenic
bacteria
host
tissues
facilitates
their
escape
from
defences.
crucial
mitigating
exaggerated
inflammatory
reactions
within
host's
system
during
instances
infection
inflammation.
also
relationship
between
disease
systemic
diseases.
promotes
wound
healing
may
enhance
implant
osseointegration.
This
study
reviews
autophagy's
dento‐alveolar
effects,
focusing
on
its
odontogenesis,
diseases,
dental
surgery,
providing
valuable
insights
dentists
tooth
applications.
A
thorough
examination
autophagy
has
potential
to
discover
novel
efficacious
treatment
targets
field
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(13), P. 3781 - 3781
Published: June 27, 2024
Periodontitis
is
a
multifactorial
chronic
inflammatory
disease
that
affects
the
periodontium
and
overall
oral
health
primarily
caused
by
dysbiotic
gingival
biofilm,
which
includes,
among
others,
Gram-negative
bacteria
such
as
Therapeutic Advances in Chronic Disease,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 1, 2023
Periodontitis
is
a
persistent
inflammation
of
the
soft
tissue
around
teeth
that
affects
60%
population
in
globe.
The
self-maintenance
inflammatory
process
can
cause
periodontal
damage
from
alveolar
bone
resorption
to
tooth
loss
order
contrast
effects
periodontitis,
main
therapy
used
scaling
and
root
planing
(SRP).
At
same
time,
studying
physiopathology
periodontitis
has
shown
possibility
using
local
drug
delivery
system
as
an
adjunctive
therapy.
Using
devices
conjunction
with
SRP
for
potential
tool
since
it
increases
efficacy
minimizes
negative
by
managing
release.
This
review
emphasized
how
use
agents
natural
could
be
promising
adjuvants
treatment
patients
affected
or
not
cardiovascular
disease,
diabetes,
other
problems.
Moreover,
evidences
current
issues
new
ideas
inspire
later
study
both
basic
research
clinical
practice
tailored
approach.
