International Dental Journal, Journal Year: 2025, Volume and Issue: 75(3), P. 1771 - 1780
Published: April 15, 2025
Language: Английский
Periodontology 2000, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Abstract To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis systemic diseases through bibliometric visual analysis. A search was conducted using Web Science database, covering period 1989 to 2024. The Medical Subject Headings (MeSH) from US National Library Medicine used categorize conditions, focusing on terms unrelated stomatognathic diseases. analysis included keyword co‐occurrence mapping, co‐authorship, bibliographic coupling, co‐citation Quality indicators such as silhouette score, modularity, centrality were considered assess network's quality. research strategy identified 6106 records, which 1519 met inclusion criteria. revealed that 46.73% literature topic published in last 5 years annual publication trend peaked 2023. Nutritional & Metabolic Diseases ( n = 398), Cardiovascular 335), Female Urogenital Pregnancy Complications 244), Musculoskeletal 182) most representative categories associated with periodontitis. co‐cited journals Journal Periodontology 1412), Clinical 1343), Dental Research 940), 2000 849). USA, China, Brazil, Sweden countries contributed number publications. present study growing evaluating association diseases, highlighting negative impact plethora conditions rising translational interest this relationship. With an aging population, is expected affect people coming decades, presenting significant challenges public health. Improved knowledge is, therefore, essential enable more care, preventive strategies, optimal oral health for patients
Language: Английский
Citations
10
Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 35 - 35
Published: Jan. 9, 2025
Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by dysbiotic oral microbiota and negatively correlated with several systemic diseases. The low-chronic burden gingival inflammation not only exacerbates periodontitis but also predisposes individuals to spectrum age-related conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic dysfunction, especially related ageing. In this regard, over local periodontal treatment, lifestyle modifications adjunctive therapies may offer synergistic benefits in ameliorating both health ageing populations. Elucidating intricate connections between senescence important for understanding health's implications Effective management strategies targeting senescent pathways novel avenues promoting healthy preventing morbidities. This review will analyze current literature about interplay periodontitis, dysbiosis, processes senescence, shedding light on their collective impact modulation accelerated Lastly, therapeutic dysbiosis mitigate its associated morbidities be discussed.
Language: Английский
Citations
1
iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112182 - 112182
Published: March 7, 2025
Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, Web Science were comprehensively searched until 4 December 2024, 10 randomized controlled trials (RCTs) included. The results indicated that, compared control group, significantly reduced probing depth (PD) (SMD = -0.77, 95% confidence interval [CI] (-1.37, -0.16)) but did not reduce clinical attachment loss (CAL) -0.18, CI (-0.60, 0.23)), sites with glycated hemoglobin (HbA1c) 0.03, (-0.38, 0.43)), plaque index -0.37, (-0.80, 0.06)), bleeding on (BOP) -0.26, (-0.68, 0.16)), gingival 0.07, (-0.30, 0.44)). Subgroup analysis by different elicited treatment, chlorhexidine was effective reducing BOP% -0.55, (-0.90, -0.19)). finds that diabetes is limited.
Language: Английский
Citations
1
Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104559 - 104559
Published: March 1, 2025
While dental pulp stem cells (DPSCs) show therapeutic potential for spinal cord injury (SCI), post-traumatic oxidative stress and mitochondrial dysfunction critically compromise grafted cell survival. Photobiomodulation therapy (PBMT) is a noninvasive approach that may enhance regenerative efficacy. This study investigates whether PBMT improves the survival neural differentiation of transplanted DPSCs in SCI models. In vitro, anti-apoptotic effects were investigated H2O2-induced model via TUNEL staining, flow cytometry, biochemical assays transmission electron microscopy. vivo, restoration was evaluated using behavioral tests histological status respectively tracked through bioluminescence imaging immunofluorescent staining co-expressing luciferin green fluorescent protein (Luc-GFP-DPSCs) mice with/without PBMT. demonstrated protective by relieving apoptosis engrafted vitro. Furthermore, PBMT-assisted transplantation significantly promoted differentiation, achieving superior functional recovery compared to alone. facilitates mitigation enhancement differentiation.
Language: Английский
Citations
1
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1317 - 1331
Published: Jan. 1, 2025
Periodontitis is a prevalent yet frequently overlooked oral disease that linked to range of systemic conditions. Although basic treatment and periodontal surgery can alleviate the symptoms periodontitis certain extent, severe tissue defects or refractory cases not effective. Extracellular vesicles (EVs) are subcellular lipid bilayer particles come from variety sources in biological fluids vertebrates. They play key role intercellular communication by transporting multiple signaling molecules. Recent research has indicated EVs derived pathogens trigger periodontitis, exacerbate damage, potentially disseminate other parts body, leading Conversely, extracellular dental stem cells (DSCs) have demonstrated ability regulate local immune environment foster regeneration repair tissues, positioning them as promising candidate for cell-free therapeutic approaches periodontitis. This review aims summarize latest on involvement different pathogenesis especially systematically elucidate mechanism secreted periodontitis-related diseases first time. By uncovering these complex regulatory processes, new more effective be explored battle against its associated diseases.
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1875 - 1886
Published: Feb. 1, 2025
Background and Objective: Periodontitis is a chronic inflammatory disease caused by dental plaque accumulation, leading to damage of periodontal tissues potential tooth loss. Understanding the mechanisms periodontitis, particularly role hypoxia in inflammation, critical for identifying novel therapeutic strategies. This study investigated effects prolyl hydroxylase (PHD) inhibitor DMOG on pro-inflammatory cytokine expression human ligament stem cells (hPDLSCs) examined involvement HIF-1α/YAP signaling path ay modulating inflammation. Materials Methods: hPDLSCs were cultured treated with lipopolysaccharide (LPS) induce followed treatment. Cell proliferation was assessed using CCK-8 assay, while ELISA RT-qPCR evaluated levels HIF-1α, IL-1β, TNF-α, YAP. YAP knocked down siRNA transfection examine its cytokines. Results: significantly increased HIF-1α reducing IL-1β TNF-α LPS-treated hPDLSCs. 0.1 mmol/L inhibited cell after 72 hours (P < 0.001). results showed that concentrations LPS + group higher than 0.01), reduced 0.01). confirmed these trends, showing mRNA 0.0001). knockdown via reversed effects, increasing 0.01) 0.05). Conclusion: demonstrated reduces stabilizing activating pathway. These findings provide mechanistic basis targeting axis control inflammation support PHD inhibitors as agents periodontitis. Keywords: YAP, DMOG,
Language: Английский
Citations
0
CyTA - Journal of Food, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 13, 2025
Language: Английский
Citations
0
Journal of International Society of Preventive and Community Dentistry, Journal Year: 2025, Volume and Issue: 15(2), P. 126 - 133
Published: March 1, 2025
A bstract Aim: Gingival fibroblasts are key players in oral wound healing as they migrate to the and produce extracellular matrix. Although contemporary methods can enhance healing, there is ongoing interest alternative medicine due its accessibility. Kaempferia parviflora , a traditional Thai herb, has been comprehensively studied for pharmacological properties; however, specific roles remain be explored. Thus, our study aimed investigate effects of K. extract (KPE) on proliferation, migration, collagen production human gingival (HGFs). Methods: HGFs were treated with 0.46–7.5 mg/mL KPE, followed by determination cell viability using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay days 1, 3, 5, 7, migration was assessed scratch at 12, 24, 48 h. Collagen analyzed picrosirius red staining real-time polymerase chain reaction (qRT-PCR) 14, 21. Results: At 0.46 mg/mL, KPE induced proliferation whereas higher concentrations cytotoxic HGFs. This concentration also enhanced all time points, doses hampered this process. stimulated upregulated expressions COL3A1 COL1A1 genes day although these levels decreased Conclusions: could promote HGFs, demonstrating potential use an adjunctive treatment wounds. Nevertheless, establishing safety margin crucial before clinical application possibility cytotoxicity concentrations.
Language: Английский
Citations
0
Journal of Nutritional Science, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 1, 2025
Abstract This cross-sectional study aimed to investigate the correlation between magnesium consumption and periodontitis in different body mass index (BMI) waist circumference (WC) groups. 8385 adults who participated National Health Nutrition Examination Survey during 2009–2014 were included. The dietary intake was first tested for statistical significance by descriptive statistics weighted binary logistic regression. Subgroup analysis interaction tests performed whether association stable BMI WC There a difference non-periodontitis populations. In model 3, participants with highest had an odds ratio of 0.72 (0.57-0.92) compared those lowest consumption. However, subgroup analysis, relationship remained significant only non-general obese (BMI ≤ 30 kg/m 2 ) non-abdominal populations (WC 102 cm men 88 women). Dietary might decrease prevalence American population, this beneficial periodontal health role be evident
Language: Английский
Citations
0
Frontiers in Dental Medicine, Journal Year: 2025, Volume and Issue: 6
Published: May 20, 2025
Language: Английский
Citations
0