Biological potential, metabolite profiling and in silico analysis of pomelo (Citrus maxima L.) leaf DOI
Mital J. Kaneria, Anil Patani, Kalpna Rakholiya

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract BACKGROUND Citrus maxima L., commonly known as pomelo, is renowned for its rich array of bioactive compounds, which hold notable therapeutic potential. The present study explores the profile pomelo leaves, focusing on their antioxidant and antimicrobial properties. RESULTS activity was tested using various radical scavenging assays, showed a strong ability to remove free radicals. agar well diffusion method used evaluate against pathogenic microbial strains further minimum inhibitory concentration bactericidal meaurements were performed with potent properties exhibited remarkable inhibition. Gas chromatography‐quadrupole time‐of‐flight mass spectrometry liquid carry out full metabolite profiling maceration ethanol extracts. This analysis identified 65 compounds. Furthermore, studies molecular docking conducted predict interaction key compounds specific biological targets, providing information about potential mechanisms action. CONCLUSION emphasizes significance selecting most effective extraction methods maximize amount leaf Compounds number 16 (menadiol dibutyrate), 25 (5‐[(4‐hydroxypheny) ethenyl]‐2‐(3‐methyl‐1‐butenyl)‐1,3‐ benzenediol) 51 (3‐hydroxycoumarin) in silico molecules selected protein receptors, are recommended drug discovery development. findings offer valuable insights development functional foods, nutraceuticals pharmaceuticals derived from C. L. highlighting role mitigating oxidative stress preventing chronic diseases. can pave way innovative applications health nutrition sectors. © 2025 Society Chemical Industry.

Language: Английский

Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties DOI Open Access
Devang R. Prajapati, Masuma Hakim,

Margi Patel

et al.

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(2)

Published: Jan. 28, 2025

ABSTRACT The present study aimed to optimize a mouth‐dissolving film (MDF) made from Pongamia pinnata stem bark extract increase patient compliance and accelerate oral disease therapy. Several extracts were prepared, karanjin was used as an herbal marker for the extracts. ethanolic showed maximum yield (12.10% ± 0.09%) cytotoxic activity against human cancer (KB 3‐1) embryonic kidney cell lines. MDF formulation focused on incorporating fixed amount of varying concentrations HPMC E5 polymer, along with evaluating performance plasticizers like PEG 400 propylene glycol (PG). An optimized determined based disintegration time, wetting folding endurance. consisted film‐forming PG superior plasticizer, ascorbic acid antioxidant, other ingredients contributing solubility, dispersion, sweetening, appearance. High‐performance thin‐layer chromatography‐mass spectrometry analysis confirmed higher levels in formulation, ensuring its successful incorporation stability. Taste masking evaluations indicate favorable taste profile high potential compliance. stability displayed no significant changes physical characteristics film, affirming quality. In conclusion, developed herbal‐based presents promising drug delivery system, offering enhanced compliance, masking, holds great effective treatment management diseases, providing convenience improved therapeutic outcomes.

Language: Английский

Citations

2
A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment DOI Creative Commons

Khushbu Wadhwa,

Neha Kapoor,

Hardeep Kaur

et al.

Mycobiology, Journal Year: 2024, Volume and Issue: 52(6), P. 335 - 387

Published: Nov. 1, 2024

Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to increasing applications healthcare, environmental cleanup, biotechnology-based industries. The fungi produce these metabolites (SMs) during different phases of growth, which are categorized into terpenoids, alkaloids, polyketides, non-ribosomal peptides. These SMs exhibit significant biological activity, contributes formulation novel pharmaceuticals, biopesticides, bioremediation agents. Nowadays, fungal-derived widely used food beverages, for fermentation, preservatives, protein sources, dairy In it is being as an antimicrobial, anticancer, anti-inflammatory, immunosuppressive drug. usage modern tools biotechnology can achieve increase large-scale production. present review comprehensively analyses diversity fungal along with emerging agriculture, sustainability, nutraceuticals. Here, authors reviewed recent advancements genetic engineering, metabolic pathway manipulation, synthetic biology improve production yield SMs. Advancement fermentation techniques, bioprocessing, co-cultivation approaches Investigators further highlighted importance omics technologies understanding regulation biosynthesis SMs, offers drug discovery sustainable agriculture. Finally, addressed potential manipulation biotechnological innovations exploitation commercial benefits.

Language: Английский

Citations

6
Curcumin‐loaded nanoparticles effectively prevent T4‐induced oxidative stress in rat heart DOI
Pallavi Mishra, Dipak Kumar Sahoo, Chandana Mohanty

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)

Published: June 1, 2024

Abstract In this study, we report the cardioprotective effect of glycerol monooleate (GMO) based nanocurcumin in both vitro and vivo conditions under a hyperthyroid state. The heart is one primary target organs sensitive to action thyroid hormone, slight variations hormone serum concentrations result measurable changes cardiac performance. Hyperthyroidism‐induced hypermetabolism associated with oxidative stress an important mechanism responsible for progression failure. Curcumin has been known play protective role against stress‐related diseases like Alzheimer's, asthma, aging due its antioxidant properties. Nevertheless, potent biological activity hindered poor bioavailability. To overcome drawback, GMO‐based biodegradable nanoparticle (NP) formulation loaded curcumin developed, curcumin‐loaded NPs was compared native drug. Oxidative parameters reactive oxygen species (ROS) release, change mitochondrial membrane permeability, lipid peroxidation (LPx), lactate dehydrogenase (LDH) protein expression endogenous enzymes superoxide dismutase, catalase (CAT) glutathione peroxidase were evaluated. results from showed that better DPPH NO radical scavenging than range 2.5–20 µM. It also observed nanoparticulate comparatively more effective protecting ROS‐induced damage by reducing LPx LDH leakage at low 5–10 Further, performed facilitating activities respect time concentrations, resulting reduced cellular ROS levels. scenario, anticipate can serve as counterpart diseases.

Language: Английский

Citations

4
Recent advancement in mass based plant metabolomics: techniques, tools, and analytical approaches DOI

Nitish Kumar,

Jare Shrikrushna Bharat,

Amit Kumar

et al.

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Language: Английский

Citations

4
Biological potential, metabolite profiling and in silico analysis of pomelo (Citrus maxima L.) leaf DOI
Mital J. Kaneria, Anil Patani, Kalpna Rakholiya

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract BACKGROUND Citrus maxima L., commonly known as pomelo, is renowned for its rich array of bioactive compounds, which hold notable therapeutic potential. The present study explores the profile pomelo leaves, focusing on their antioxidant and antimicrobial properties. RESULTS activity was tested using various radical scavenging assays, showed a strong ability to remove free radicals. agar well diffusion method used evaluate against pathogenic microbial strains further minimum inhibitory concentration bactericidal meaurements were performed with potent properties exhibited remarkable inhibition. Gas chromatography‐quadrupole time‐of‐flight mass spectrometry liquid carry out full metabolite profiling maceration ethanol extracts. This analysis identified 65 compounds. Furthermore, studies molecular docking conducted predict interaction key compounds specific biological targets, providing information about potential mechanisms action. CONCLUSION emphasizes significance selecting most effective extraction methods maximize amount leaf Compounds number 16 (menadiol dibutyrate), 25 (5‐[(4‐hydroxypheny) ethenyl]‐2‐(3‐methyl‐1‐butenyl)‐1,3‐ benzenediol) 51 (3‐hydroxycoumarin) in silico molecules selected protein receptors, are recommended drug discovery development. findings offer valuable insights development functional foods, nutraceuticals pharmaceuticals derived from C. L. highlighting role mitigating oxidative stress preventing chronic diseases. can pave way innovative applications health nutrition sectors. © 2025 Society Chemical Industry.

Language: Английский

Citations

0