Metabolites,
Journal Year:
2025,
Volume and Issue:
15(3), P. 183 - 183
Published: March 9, 2025
Headspace
analysis
is
an
effective
method
for
assessing
the
concentrations
of
volatile
and
semi-volatile
metabolites
in
biological
samples.
In
particular,
solid-phase
microextraction
(SPME)
efficient
tool
headspace
analyses.
Metabolites
present
sample
are
typical
targets
(rather
than
vapor
phase
concentration)
making
measurements
on
donors
(e.g.,
biomarkers
health
or
disease).
Accordingly,
intermolecular
forces
between
matrix
may
prevent
a
complete
profile
metabolite
composition
biosamples
from
being
revealed.
To
assess
sources
such
interactions,
several
compounds
various
mediums
were
examined.
Small
human
selected
this
study.
Test
media
included
lipid
serum
solution
to
simulate
samples
commonly
encouraged
biomarker
discovery.
analytes
compared
using
gas
chromatography-mass
spectrometry
(SPME-GC-MS).
Observed
levels
varied
among
different
media,
despite
fortified
at
equal
Overall,
lower
responses
observed
containing
proteins
lipids.
It
was
found
that
these
strong
interactions
arose
irreversible
chemical
bonds
molecules
component
matrix.
However,
could
be
maximized
when
performed
temperatures
ranging
60
70
°C.
Furthermore,
normalization
peak
internal
standard
did
not
always
account
interactions.
Marine Pollution Bulletin,
Journal Year:
2024,
Volume and Issue:
200, P. 116099 - 116099
Published: Feb. 2, 2024
Pharmaceutical
compounds
are
micropollutants
of
emerging
concern,
as
well
other
classes
chemicals
such
UV
filters
and
artificial
sweeteners.
They
enter
marine
environments
via
wastewater
treatment
plants,
aquaculture
runoff,
hospital
effluents,
shipping
activities.
While
many
studies
have
investigated
the
presence
distribution
these
pollutants
in
numerous
coastal
areas,
our
study
is
first
to
focus
on
their
occurrence,
spatial
distribution,
vertical
sea
surface
microlayer
(SML)
near-surface
layer
environments.
We
analyzed
62
pharmaceutical
compounds,
one
filter,
six
sweeteners
from
SML
corresponding
underlying
water
(0
cm,
20
50
100
150
cm)
at
four
stations
southern
North
Sea.
One
station
enclosed
Jade
Bay,
Weser
estuary
Bremerhaven,
two
(NS_7
NS_8)
open
German
Bight.
Bay
receives
surrounding
while
cities
like
which
has
dense
populations
industrial
Concentrations
were
higher
upper
layers
(from
cm).
Eleven
(caffeine,
carbamazepine,
gemfibrozil,
ibuprofen,
metoprolol,
salicylic
acid,
clarithromycin,
novobiocin,
clindamycin,
trimethoprim,
tylosin)
detected
>95
%
samples.
filter
(benzophenone-4)
was
found
83
three
(acesulfame,
saccharin,
sucralose)
all
All
posed
high
risks
freshwater
invertebrate
Daphnia
magna.
Understanding
pharmaceuticals
may
be
essential
assessing
dispersal
detection
aquatic
Journal of Separation Science,
Journal Year:
2024,
Volume and Issue:
47(9-10)
Published: May 1, 2024
Determination
of
proteins
from
dried
matrix
spots
using
MS
is
an
expanding
research
area.
Mainly,
the
collected
sample
whole
blood
a
finger
or
heal
prick,
resulting
in
spots.
However
as
other
matrices
such
plasma,
serum,
urine,
and
tear
fluid
also
can
be
this
way,
term
spot
used
overarching
term.
In
review,
focus
on
advancements
field
made
2017
up
to
2023.
first
part
reviews
concerning
subject
are
discussed.
After
this,
for
clinical
purposes
highlighted.
Both
targeted
protein
analyses,
with
without
use
affinity
extractions,
well
untargeted,
global
proteomic
approaches
last
part,
both
methodological
being
reviewed
possibility
integrate
preparation
steps
during
handling.
The
focus,
so‐called
smart
sampling,
incorporation
cell
separation,
proteolysis,
antibody‐based
capture.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
The
sensitive
detection
of
trace
biomarkers
in
exhaled
breath
for
lung
cancer
diagnosis
represents
a
critical
area
research
life
analytical
chemistry,
with
profound
implications
early
disease
detection,
therapeutic
intervention,
and
prognosis
monitoring.
Despite
its
potential,
the
process
faces
significant
challenges
due
to
ultratrace
levels
present
complex,
high-humidity
composition
breath.
This
study
introduces
highly
method
detecting
aldehyde
by
integrating
use
amino-functionalized
microporous
organic
networks
(NH
