Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application DOI Creative Commons
Katsuhiko Ariga

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Nanoarchitectonics, as a post‐nanotechnology concept, represents methodology for the construction of functional materials employing atoms, molecules, and nanomaterials essential components. The overarching objective nanoarchitectonics is to develop systems comprising multiple units assembled in hierarchical manner, observed biological systems. Nevertheless, such challenging endeavor. It would be prudent, therefore, initially focus on development that interact with complex structures living organisms. Accordingly, this review article addresses topic nanoarchitecture it pertains biomedical applications. This examines current trends research presents examples studies support concept its applications fields. presented are follows: i) molecular developments, which mainly based design assembly; ii) material examples, using components; iii) porous materials, will summarized under heading pore‐engineered due their special structure. Finally, provides an overview these discusses future prospects.

Language: Английский

MOFs with hierarchical nanostructures towards future functional polymers DOI Creative Commons

Xiuhong Sun,

Tao Lin, Yanbei Hou

et al.

Nano Materials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

3
Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine DOI
Marzieh Ramezani Farani, Iman Zare,

Mojdeh Mirshafiei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

Citations

2
Heterojunctions Based on 2D Materials for Pulse Laser Applications DOI
Zheng Zhang, Binglong Lei, Yang Tan

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

In recent years, heterostructures composed of two-dimensional (2D) materials have demonstrated broad application prospects across various domains, primarily attributed to their exceptional electrical and optical properties. The superior performance these is rooted in the interlayer interactions diversity constituent materials. Notably, applications been greatly advanced fields such as photodetectors, lasers, modulators, sensors, nonlinear optics. etc. This review delineates advancement based on 2D discusses electronic structural properties interfaces band alignments while summarizing carrier dynamics characteristics. Furthermore, it explores synthesis techniques saturable absorbers laser Q-switching mode-locking, emphasizing critical role that type-I type-II heterojunctions played advancing technology. Lastly, challenges future opportunities technologies are reviewed, offering insights potential directions for further research this field.

Language: Английский

Citations

1
Mechanical Force on Hydrogel Implication on Enhanced Drug Release, Antibacterial, and M2 Macrophage Polarization: New Insights Alleviate Diabetic Wound Healing DOI

Sivaraj Mehnath,

Kandhasamy Karthikeyan,

Murugaraj Jeyaraj

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Diabetic foot ulcers/chronic wounds are difficult to treat because of dysfunctional macrophage response and decreased phenotype transition from the M1 M2 status. This causes severe inflammation, less angiogenesis, microbial infections, small deformation in wound beds, affecting healing process. The commercial dressing material has limited efficacy, poor mechanical strength, extra pain, new granulated tissue formed a mesh gauze. It is desired create tough, skin-adhesive, antifouling, sustainable phenotype-enabling, mechanoresponsive drug-releasing hydrogel. To resolve this, zwitterionic poly(sulfobetaine methacrylate) (SB) incorporated with keratin-exfoliated MoS

Language: Английский

Citations

5
Aggregation-Induced Emission Luminogen Based Wearable Visible-Light Penetrator for Deep Photodynamic Therapy DOI
Kun Zhou, Ying Yu, Letian Xu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29930 - 29941

Published: Oct. 18, 2024

Photodynamic therapy (PDT) has emerged as a preferred nonsurgical treatment in clinical applications due to its capacity selectively eradicate diseased tissues while minimizing damage normal tissue. Nevertheless, efficacy is constrained by the limited penetration of visible light. Although near-infrared (NIR) lasers offer enhanced tissue penetration, dearth suitable photosensitizers and pronounced imaging-treatment disparity pose challenges. Additionally, implementation via optical fiber implantation carries infection risks necessitates minimally invasive surgery, contradicting PDT's noninvasive advantage. In this study, we introduce brilliant approach utilizing aggregation-induced emission luminogens (AIEgen) develop visible-light penetrator (VLP), coupled with wireless light emitting diodes (LEDs), enabling deep photodynamic therapy. We validate therapeutic inaccessible conventional PDT, demonstrating significant suppression inflammatory diffusion vivo using AIEgen TBPPM loaded within VLP, which exhibits transmittance 86% thickness 3 mm. This innovative effectively overcomes substantial limitations PDT settings holds promise for advancing phototherapy.

Language: Английский

Citations

4
Photodynamic and Sonodynamic Therapy Synergy: Mechanistic Insights and Cellular Responses Against Glioblastoma Multiforme DOI
Swati Sharma,

Geetanjali B. Gone,

Parikshit Roychowdhury

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Nov. 18, 2024

Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, poses substantial challenges to effective treatment due its complex and infiltrative nature, making it difficult manage. Photodynamic therapy (PDT) sonodynamic (SDT), have emerged as promising individual options against GBM their least-invasive approach. However, both PDT SDT drawbacks that require careful consideration. A combination using light sound waves has gained attention, offering new avenues overcome from therapies. Sono-photodynamic (SPDT) been used various tumors. Researchers are considering SPDT a favorable alternative conventional therapies for GBM. offers complementary mechanisms action, including production ROS, disruption cellular structures, induction apoptosis, leading enhanced tumor cell death. This review gives an insight about PDT/SDT limitations in need therapy. We try unveil process explore mechanism behind improved SPDT-meditated death cells by focusing on ROS-mediated response occurring result discussing current modifications existing sensitizers optimal use

Language: Английский

Citations

4
Facile Alkyne Assembly-Enabled Functional Au Nanosheets for Photoacoustic Imaging-Guided Photothermal/Gene Therapy of Orthotopic Glioblastoma DOI
Xixi Hu,

Peiling Li,

Dongdong Xu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Treatment of glioblastoma (GBM) remains challenging due to the presence blood-brain barrier (BBB) and tumor heterogeneity. Herein, Au nanosheets (AuNSs) functionalized with RGD peptides small interfering RNA (siRNA), referred as AuNSs-RGD-C≡C-siRNA (ARCR), are prepared achieve multimodal therapy for GBM. The AuNSs a large modifiable surface area, intriguing photothermal conversion efficiency (50.26%), remarkable stability (44 cycles over 7 h) created using well-designed amphiphilic surfactant. Furthermore, alkynyl groups assembled onto within 1 min, enabling strong covalent binding siRNA thereby avoiding interference from biological thiols. Owing lipophilicity surfactant targeting property RGD, ARCR effectively passes through BBB accumulates in GBM regions, allowing near-infrared photoacoustic imaging-guided photothermal/gene therapy. This work proposes facile strategy construct theranostic Au-based materials, highlighting potential multifunctional nanoagents

Language: Английский

Citations

4
Quantitative evaluation of surface crack depth on notched bars with laser-infrared detection technology DOI
Jiayi Xu, Lijun Zhang, Hang Wang

et al.

Nondestructive Testing And Evaluation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 20, 2025

Language: Английский

Citations

0
Nanobody-Mediated Cellular Uptake Maximizes the Potency of Polylysine Dendrimers While Preserving Solid Tumor Penetration DOI
Daniel Yuen, Orlagh M. Feeney,

Leo Noi

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Dendrimers are branched macromolecular structures that useful nanocarriers for small-molecule drugs, such as cancer therapeutics. Their small size permits penetration into solid tumors, coupled with functionalization a low-fouling PEG coating minimizes transient cellular interactions and enhances plasma circulation time. While PEGylated dendrimers show significant promise anticancer therapeutics, there is potential to increase tumor cell specificity drive uptake of drugs cells by conjugating cell-targeting ligands onto the dendrimers. To achieve this, we used an expanded genetic code bio-orthogonal click chemistry functionalize monomethyl auristatin E (MMAE)-loaded single nanobody per dendrimer. The uniform addition ligand facilitated greater intracellular drug payload HER2-positive target cells, while preserving desirable circulatory characteristics nanobody–dendrimer conjugates similar levels infiltration over 24 h compared unmodified dendrimers, targeted had significantly inhibition growth long-term retention in tumors. Our results highlight biodistribution studies alone poor predictors therapeutic performance. controlled conjugation strategy presented here preserves advantage tissue maximizing potency difficult-to-access tissue.

Language: Английский

Citations

0
Black Phosphorus Nanosheet-Based Composite Biomaterials for the Enhanced Repair of Infectious Bone Defects DOI
Wen Yin,

Shouye Sun,

Hongyuan Yao

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Infectious bone defects pose significant challenges in orthopedic practice, marked by persistent bacterial infection and ongoing inflammatory responses. Recent advancements tissue engineering have led to the development of biomaterials with both antibacterial properties ability promote regeneration, offering new solutions these complex issues. Black phosphorus nanosheets (BPNS), a unique two-dimensional material, demonstrate exceptional biocompatibility, bioactivity, properties. Their combination osteogenic, antibacterial, anti-inflammatory effects positions BPNS as an ideal candidate for addressing complicated infection. This Review explores potential BPNS-based composite repairing infectious defects, discussing their molecular mechanisms activity, including intrinsic properties, photothermal therapy (PTT), photodynamic (PDT), drug delivery. The application treating through hydrogels, scaffolds, coatings, fibers, is also discussed. emphasizes transformative role advocates continued research this promising field.

Language: Английский

Citations

0