Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity
Weidong Xiao,
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Mingquan Gao,
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Banghui Mo
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et al.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(4), P. 491 - 491
Published: March 28, 2025
Background:
Endoplasmic
reticulum
(ER)-targeted
phototherapy
has
emerged
as
a
promising
approach
to
amplify
ER
stress,
induce
immunogenic
cell
death
(ICD),
and
enhance
anti-tumor
immunity.
However,
its
impact
on
the
antigenicity
of
dying
tumor
cells
remains
poorly
understood.
Methods:
Laser
activation
ER-targeted
photosensitizer
ER-Cy-poNO2
was
performed
investigate
effects
antigenicity.
Transcriptomic
analysis
carried
out
assess
gene
expression
changes.
Immunopeptidomics
profiling
used
identify
high-affinity
major
histocompatibility
complex
class
I
(MHC-I)
ligands.
In
vitro
functional
studies
were
conducted
evaluate
dendritic
maturation
T
lymphocyte
activation,
while
in
vivo
experiments
by
combining
identified
peptide
with
poly
IC
Results:
significantly
remodeled
antigenic
landscape
4T-1
cells,
enhancing
their
immunogenicity.
revealed
upregulation
antigen
processing
presentation
pathways.
multiple
MHC-I
ligands,
IF4G3986–994
(QGPKTIEQI)
showing
exceptional
vitro,
promoted
enhanced
lymphocytes
activation.
vivo,
combination
elicited
robust
immunity,
characterized
increased
CD8+
infiltration,
reduced
regulatory
(Tregs)
microenvironment,
elevated
systemic
Interferon-gamma
(IFN-γ)
levels,
significant
growth
inhibition
without
toxicity.
Conclusions:
These
findings
establish
mechanistic
link
between
stress-driven
ICD,
immunopeptidome
remodeling,
adaptive
immune
highlighting
potential
platform
for
identifying
peptides
advancing
peptide-based
cancer
vaccines.
Language: Английский
A novel imidazolium functionalized tetraphenylethane for ATP detection and photoinduced ROS generation
Dyes and Pigments,
Journal Year:
2025,
Volume and Issue:
unknown, P. 112720 - 112720
Published: Feb. 1, 2025
Language: Английский
Optical Microneedle-Enhanced Transdermal Light Scattering for In Situ Photothermal Therapy Targeting Basal-Layer Psoriasis
Ze Qiang Zhao,
No information about this author
S.-L. Zhang,
No information about this author
Ruixing Yu
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et al.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Near-infrared
(NIR)
light-mediated
photothermal
and
photodynamic
therapies
are
promising
for
nonsurgical
treatment
of
skin
diseases.
However,
the
skin's
inherent
light
absorption,
especially
from
melanin
in
epidermis,
attenuates
NIR
energy
penetration,
limiting
efficacy
potentially
causing
off-target
tissue
damage.
In
this
context,
we
developed
subcutaneous
response-enhanced
microneedles
(SLE
MNs)
that
allow
basal
layer-localized
seeding
therapeutics
leverage
physical
channels
to
efficiently
transmit
transdermally,
facilitating
situ
scattered
activation
enhanced
therapy
outcomes.
Such
ultraoptical
SLE
MNs
facilitated
achieving
up
80%
initial
power
at
500
μm
subcutaneously,
representing
an
approximate
160%
increase
compared
control
groups.
Additionally,
conceptualized
a
two-segmented
MN
structure
integrating
light-guiding
with
photoresponsive
enable
precise
basal-layer
treatment,
effectively
mitigating
local
hyperenergy
on
surface
attenuation
within
tissues.
This
optical
patch
offers
transformative
platform
transdermal
significant
clinical
potential.
Language: Английский
Photosensitive materials armed bacteriophages: Latest advances and prospects
Jinyou Xu,
No information about this author
Zhengfang Luo,
No information about this author
Xiaoyu Xu
No information about this author
et al.
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 162429 - 162429
Published: April 1, 2025
Language: Английский
Data mining analysis of Dunhuang ancient medical prescriptions for the treatment of surgical diseases
Asian Journal of Surgery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Language: Английский
Construction of Triphenylamine-Based Aggregation-Induced Emission Luminogens for Lysosomes Imaging and Its Application in the Photodynamic Therapy of Cancer Cells
Zhanguo Sun,
No information about this author
Bin Liu,
No information about this author
Huijun Liu
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et al.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(11), P. 2272 - 2272
Published: May 22, 2025
Lysosomes
are
important
acidic
subcellular
organelles
whose
dysfunction
can
lead
to
some
related
diseases.
The
development
of
new
lysosome-imaging-guided
AIEgens
for
the
photodynamic
therapy
cancer
cells
is
important.
In
this
work,
two
novel
organic
compounds
with
AIE
characteristics,
namely,
TPAB-CF3
and
TPAB-diCF3,
were
designed
synthesized
by
introducing
weakly
basic
morpholinyl
moiety
lysosome-targeting
ability
into
a
triphenylamine-based
luminogen.
distorted
spatial
feature
TPA
D1-D2-π-A
structure
these
prevented
aggregation-caused
quenching
traditional
fluorescent
molecules
efficiently
promoted
separation
HOMO
LUMO.
outcomes
features
narrow
single-triplet
energy
gap.
Furthermore,
TPAB-diCF3
showed
bright
yellow
fluorescence
emission
peaks
at
577
601
nm;
large
Stokes
shifts
234
256
nm,
respectively;
excellent
lysosome-targeted
imaging
HeLa
(Pearson’s
coefficient
=
0.90).
addition
good
1O2-generation
under
light
irradiation,
achieved
high-efficiency
lysosome
imaging-guided
killing
white-light
irradiation.
Language: Английский