Advances in dietary polysaccharides as anticancer agents: Structure-activity relationship

Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 111, P. 360 - 377

Published: March 13, 2021

The discovery of nutritious dietary supplements and side effect-free therapeutics are a priority in the current scenario increasing cancer cases. Natural anticancer polysaccharides have shown immense potential. As class biomacromolecules produced by variety species including plants, animals, fungi, bacteria algae, drawn considerable interest over recent years as they possess activities with fewer effects. from different sources various structures activities. But it is difficult to compare their bioactivities those synthetic drugs for inherently physicochemical properties, poor water solubility, low molecular weight branching degree. However, some chemical modification methodologies (e.g., sulfation, phosphorylation, selenylation zinc impregnation) could significantly increase grafting other groups boost activity. Numerous studies focused on evaluation mechanism action further applications. Polysaccharides considered anti-tumor agents immunomodulatory activity toxicity been used clinical or adjuvant treatment tumors. complex structure unclear anti-cancer brought great restrictions research application. Therefore, important human resist tumors elucidating antitumor effects resources correlation, discussing application combination chemotherapy vaccine adjuvants.

Language: Английский

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Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders

Molecules, Journal Year: 2021, Volume and Issue: 26(6), P. 1510 - 1510

Published: March 10, 2021

The use of naturally occurring materials in biomedicine has been increasingly attracting the researchers' interest and, this regard, gum tragacanth (GT) is recently showing great promise as a therapeutic substance tissue engineering and regenerative medicine. As polysaccharide, GT can be easily extracted from stems branches various species Astragalus. This anionic polymer known to biodegradable, non-allergenic, non-toxic, non-carcinogenic material. stability against microbial, heat acid degradation made an attractive material not only industrial settings (e.g., food packaging) but also biomedical approaches drug delivery). Over time, shown useful reagent formation stabilization metal nanoparticles context green chemistry. With advent engineering, utilized for fabrication three-dimensional (3D) scaffolds applied both hard soft healing strategies. However, more research needed defining applicability future engineering. On object, present review aims provide state-of-the-art overview tries open new horizons field based on its inherent characteristics.

Language: Английский

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Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(5), P. 2069 - 2106

Published: April 22, 2022

Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue culminates with remodeling. These steps significantly overlap each other are aided by various factors such as cells, cytokines (both anti- pro-inflammatory), growth that aid in the formation. In all these advanced biomaterials provide several functional advantages, removing exudates, providing cover, transporting oxygen to site, preventing infection from microbes. addition, serve vehicles carry proteins/drug molecules/growth and/or antimicrobial agents target site. this review, we report recent advancements biomaterials-based regenerative strategies augment skin process. conjunction medical sciences, designing nanoengineered is gaining significant attention for numerous functionalities trigger repair. regard, highlight advent of nanomaterial-based constructs healing, especially those being evaluated clinical settings. Herein, also emphasize competence versatility three-dimensional (3D) bioprinting technique management. Finally, discuss challenges perspective biomaterial-based dressings, along prospective future directions. With utilize a cocktail cell sources, agents, drugs, factors, it expected patient-specific will be developed near future, resulting complete no scar

Language: Английский

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A Review of 3D Polymeric Scaffolds for Bone Tissue Engineering: Principles, Fabrication Techniques, Immunomodulatory Roles, and Challenges

Bioengineering, Journal Year: 2023, Volume and Issue: 10(2), P. 204 - 204

Published: Feb. 3, 2023

Over the last few years, biopolymers have attracted great interest in tissue engineering and regenerative medicine due to diversity of their chemical, mechanical, physical properties for fabrication 3D scaffolds. This review is devoted recent advances synthetic natural polymeric scaffolds bone (BTE) therapies. The comprehensively discusses implications biological macromolecules, structure, composition used BTE. Various approaches fabricating BTE are discussed, including solvent casting particle leaching, freeze-drying, thermally induced phase separation, gas foaming, electrospinning, sol–gel techniques. Rapid prototyping technologies such as stereolithography, fused deposition modeling, selective laser sintering, bioprinting also covered. immunomodulatory roles utilized applications discussed. In addition, features challenges polymer fabricated using advanced additive manufacturing (rapid prototyping) addressed compared conventional subtractive Finally, applying scaffold-based treatments practice discussed in-depth.

Language: Английский

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Recent advances of chitosan-based polymers in biomedical applications and environmental protection

Journal of Polymer Research, Journal Year: 2022, Volume and Issue: 29(7)

Published: June 6, 2022

Language: Английский

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