Natural polymers in wound healing: From academic studies to commercial products

Journal of Applied Polymer Science, Journal Year: 2023, Volume and Issue: 140(22)

Published: April 12, 2023

Abstract Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that widely used in wound healing. This is due to their biocompatibility chemical structural similarity extracellular matrix (ECM). Wound healing a complex process requires multidisciplinary approach appropriate treatment product enable full recovery. Chronic nonhealing wounds significantly caused reduction. Currently, diabetic considered unmet clinical need new effective will benefit patients economy. research was aimed critically review both literature as well industrial products carbohydrates proteins dressing for wound. The outcome chitosan (CS), carbohydrate, has most application it readily available affordable, shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr not yet found use when compared CS.

Language: Английский

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Mupirocin loaded core-shell pluronic-pectin-keratin nanofibers improve human keratinocytes behavior, angiogenic activity and wound healing

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126700 - 126700

Published: Sept. 4, 2023

Language: Английский

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Platelet rich fibrin and simvastatin-loaded pectin-based 3D printed-electrospun bilayer scaffold for skin tissue regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130954 - 130954

Published: March 16, 2024

Language: Английский

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A highly compressible and expandable cellulose sponge with arch-like lamellar structures for non-compressible hemorrhage

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123255 - 123255

Published: Jan. 11, 2025

Language: Английский

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Coaxial electrospun angiogenic nanofiber wound dressing containing advanced platelet rich-fibrin

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 222, P. 1605 - 1618

Published: Sept. 15, 2022

Language: Английский

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Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 629, P. 122339 - 122339

Published: Oct. 28, 2022

Language: Английский

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A Gelatin-Based Composite Hydrogel with a “One Stone, Two Birds” Strategy for Photothermal Antibacterial and Vascularization of Infected Wounds

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(7), P. 3397 - 3410

Published: June 28, 2023

Bacterial infection, prolonged inflammation, and insufficient angiogenesis are the main challenges for effective wound repair. In this work, we developed a stretchable, remodeling, self-healing, antibacterial multifunctional composite hydrogel infected healing. The was prepared using tannic acid (TA) phenylboronic acid-modified gelatin (Gel-BA) through hydrogen bonding borate ester bonds incorporated iron-containing bioactive glasses (Fe-BGs) with uniform spherical morphologies amorphous structures to achieve GTB hydrogels. On one hand, chelation of Fe3+ in Fe-BGs TA endowed good photothermal synergistic ability; on other Si ions contained can recruit cells synergistically promote blood vessel formation. vivo animal experiments showed that hydrogels remarkably accelerated full-thickness skin healing by improving granulation tissue formation, collagen deposition, formation nerves vessels while decreasing inflammation. This dual effect ″one stone, two birds″ strategy holds immense potential dressing applications.

Language: Английский

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Zn2+ incorporated composite polysaccharide microspheres for sustained growth factor release and wound healing

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100739 - 100739

Published: July 20, 2023

The development of new wound dressings has always been an issue great clinical importance and research promise. In this study, we designed a novel double cross-linked polysaccharide hydrogel microspheres based on alginate (ALG) hyaluronic acid methacrylate (HAMA) from gas-assisted microfluidics for healing. showed uniform size good microsphere morphology. Moreover, composite were constructed by harnessing the fact that zinc ions (Zn2+) can cross-link with ALG as well histidine-tagged vascular endothelial growth (His-VEGF) to achieve long-term His-VEGF release, thus promoting angiogenesis Meanwhile, Zn2+, important trace element, exert antibacterial anti-inflammatory effects, reshaping trauma microenvironment. addition, photo HAMA was introduced into further improve its mechanical properties drug release ability. summary, Zn2+ loaded dual strategy exhibited synergistic antimicrobial angiogenic effects in

Language: Английский

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Exploring nanobioceramics in wound healing as effective and economical alternatives

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38497 - e38497

Published: Sept. 26, 2024

Language: Английский

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NIR-responsive electrospun nanofiber dressing promotes diabetic-infected wound healing with programmed combined temperature-coordinated photothermal therapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 1, 2024

Abstract Background Diabetic wounds present significant challenges, specifically in terms of bacterial infection and delayed healing. Therefore, it is crucial to address local issues promote accelerated wound In this investigation, we utilized electrospinning fabricate microgel/nanofiber membranes encapsulating MXene-encapsulated microgels chitosan/gelatin polymers. Results The film dressing facilitates programmed photothermal therapy (PPT) mild (MPTT) under near-infrared (NIR), showcasing swift extensive antibacterial biofilm-disrupting capabilities. PPT effect achieves prompt sterilization within 5 min at 52 °C disperses mature biofilm 10 min. Concurrently, by adjusting the NIR power induce heating (42 °C), stimulates fibroblast proliferation migration, significantly enhancing vascularization. Moreover, vivo experimentation successfully validates dressing, underscoring its immense potential addressing intricacies diabetic wounds. Conclusions MXene microgel-loaded nanofiber employs temperature-coordinated therapy, effectively amalgamating advantageous features high-temperature low-temperature promotion It exhibits rapid, broad-spectrum capabilities, exceptional biocompatibility, noteworthy effects on promoting cell These results affirm efficacy our highlighting challenge struggling heal due infection. Graphical

Language: Английский

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