Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7298 - 7310
Published: Oct. 8, 2024
Despite
the
increasing
interest
in
cellulose-derived
materials
biomedical
research,
there
remains
a
significant
gap
comprehensive
vivo
analyses
of
cellulosic
obtained
from
various
sources
and
processing
methods.
To
explore
durable
alternatives
to
synthetic
medical
meshes,
we
evaluated
biocompatibility
bacterial
nanocellulose,
regenerated
cellulose,
cellulose
nanofibrils
subcutaneous
transplantation
model,
alongside
incumbent
polypropylene
polydioxanone.
Notably,
this
study
demonstrates
through
alkali
dissolution
subsequent
regeneration.
All
implants
triggered
expected
foreign
body
response
host
tissue,
characterized
predominantly
by
macrophages
giant
cells.
Porous
promoted
cell
ingrowth
biointegration.
Our
results
highlight
potential
nanocellulose
as
safe
commercial
meshes.
However,
fragmentation
observed
for
nanofibril
meshes
suggests
need
measures
optimize
their
preparation.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1671 - 1671
Published: Nov. 30, 2023
Biocompatible
drug-delivery
systems
for
soft
tissue
applications
are
of
high
interest
the
medical
and
pharmaceutical
fields.
The
subject
this
research
is
development
hydrogels
loaded
with
bioactive
compounds
(inulin,
thyme
essential
oil,
hydro-glycero-alcoholic
extract
Vitis
vinifera,
Opuntia
ficus-indica
powder,
lactic
acid,
citric
acid)
in
order
to
support
vaginal
microbiota
homeostasis.
nanofibrillar
phyto-hydrogel
developed
using
biocompatible
polymers
chitosan
(CS),
never-dried
bacterial
nanocellulose
(NDBNC),
Poloxamer
407
(PX)
incorporated
water-soluble
components
NDBNC
hydrophilic
fraction
hydrophobic
core
PX
fraction.
Two
NDBNC-PX
one
NDBNC-PX-CS
hydrogel
were
structurally
physical-chemically
characterized
Fourier-transform
infrared
(FTIR)
spectroscopy,
X-ray
diffraction
(XRD),
transmission
electron
microscopy
(TEM),
rheology.
also
evaluated
terms
thermo-responsive
properties,
mucoadhesion,
biocompatibility,
prebiotic
antimicrobial
effects.
mucin
binding
efficiency
base
was
determined
by
periodic
acid/Schiff
(PAS)
assay.
Biocompatibility
MTT
test
mouse
fibroblasts.
activity
probiotic
strains
Limosilactobacillus
reuteri
Lactiplantibacillus
plantarum
subsp.
plantarum.
Antimicrobial
assessed
relevant
microbial
strains,
respectively,
E.
coli
C.
albicans.
TEM
evidenced
micelles
around
20
nm
on
nanofibrils.
FTIR
XRD
analyses
revealed
that
binary
dominated
signals,
ternary
CS,
additional
particular
fingerprints
biocompounds
interaction
mucin.
Rheology
gel
transition
temperatures
18-22
°C
thixotropic
behavior
and,
no
transition,
rheopectic
hydrogel.
adhesion
energies
be
1.2
J/m2
9.1
J/m2,
respectively.
exhibited
a
degree
potential
cell
proliferation
promote
growth
lactobacilli.
presented
significant
antibiofilm
activity.
Overpromising
has
been
a
constant
trait
of
the
nanosciences,
and
case
nanocellulose
makes
no
exception.
Regardless
substantial
academic
industrial
research
efforts
re-started
in
early
2000s,
global
production
2018
amounted
to
less
than
40,000
tonnes,
chiefly
form
microfibrillated
cellulose
for
low
value
utilization
paper
cardboard
products.
Since
2000s
market
analysts
regularly
estimate
large
annual
growth
rates
that
so
far
never
materialized.
Besides
replacement
conventional
methods
with
economically
viable
green
chemistry
processes,
fulfilling
potential
requires
learn
from
hype
technology
phase.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 31, 2024
Abstract
Bacterial
cellulose
is
a
biodegradable
and
ecologically
safe
material
that
has
the
potential
to
convert
mechanical
vibrations
into
electrical
energy.
This
review
introduces
green
energy
harvesting,
novel
concept
harnesses
natural
processes
provide
sustainable
A
thorough
overview
of
bacterial
cellulose,
covering
its
distinctive
features,
biological
origin,
conversion
process,
fully
presented.
The
different
materials
methods
used
design
fabricate
cellulose‐based
harvesters
are
explored.
Moreover,
various
applications
benefits
these
devices
in
context
renewable
examined.
current
challenges
limitations
this
emerging
field
identified
possible
avenues
for
future
research
suggested.
significance
adopting
eco‐friendly
approaches
achieving
balance
between
human
needs
environmental
preservation
highlighted.
By
providing
comprehensive
critical
assessment
as
harvester,
aims
motivate
researchers,
engineers,
policymakers
tap
rhythmic
building
more
resilient
future.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100512 - 100512
Published: May 15, 2024
Endowed
with
exceptional
chemical
and
physical
properties
that
make
it
potentially
useful
in
a
wide
array
of
industrial
sectors,
nanocellulose
remains
niche
product
chiefly
manufactured
the
form
microfibrillated
cellulose
for
low
value
utilization
paper
cardboard
products.
This
study
first
shows
case
adds
to
many
other
cases
overpromising
typical
nanosciences.
Hence,
suggests
fulfilling
potential
may
benefit
from
main
lesson
learned
during
hype
technology
cycle
(attention
trigger,
peak
inflated
expectations,
disappointment).
Renewed
management
research
efforts
aimed
at
large-scale
production
this
bionanomaterial
will
rather
focus
on
interdisciplinary
approach
green
chemistry
required
economically
viable
extraction
routes
which
replace
current
energy-intensive
wasteful
fibrillation
processes.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2327 - 2327
Published: Aug. 16, 2024
Polymer-based
dressings
deriving
from
natural
biomaterials
have
advantages
such
as
nontoxicity,
biocompatibility,
and
mechanical
stability,
which
are
essential
for
efficient
wound
healing
microbial
infection
diagnostics.
Here,
we
designed
a
prototype
of
an
intelligent
hydrogel
dressing
on
the
base
bacterial
cellulose
(BC)
monitoring
due
to
uploaded
pH
dye-sensor,
anthocyanins
(ANC)
elderberry
fruit
(Sambucus
nigra
L.).
The
highest
sensor
responses
metabolites
ANC
immobilized
BC
were
observed
at
5.0
6.0.
detection
limit
signals
was
3.45
A.U.,
it
evaluated
with
smartphone-installed
application.
FTIR
spectral
analysis
hybrid
BC/ANC
films
has
proved
presence
within
matrix.
Hybrid
differed
control
ones
by
thicker
microfibrils
larger
pores,
detected
scanning
electron
microscopy.
Halochromic
exhibited
antimicrobial
activities
mainly
against
gram-positive
bacteria
yeast.
They
showed
no
cytotoxicity
in
vitro
human
cell
lines
mouse
fibroblasts
selected
range
anthocyanin
concentrations
released
film/dressing
prototype.
Compared
control,
test
overgrowth
primary
after
applying
0.024-2.4
µg/mL
ANC.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7298 - 7310
Published: Oct. 8, 2024
Despite
the
increasing
interest
in
cellulose-derived
materials
biomedical
research,
there
remains
a
significant
gap
comprehensive
vivo
analyses
of
cellulosic
obtained
from
various
sources
and
processing
methods.
To
explore
durable
alternatives
to
synthetic
medical
meshes,
we
evaluated
biocompatibility
bacterial
nanocellulose,
regenerated
cellulose,
cellulose
nanofibrils
subcutaneous
transplantation
model,
alongside
incumbent
polypropylene
polydioxanone.
Notably,
this
study
demonstrates
through
alkali
dissolution
subsequent
regeneration.
All
implants
triggered
expected
foreign
body
response
host
tissue,
characterized
predominantly
by
macrophages
giant
cells.
Porous
promoted
cell
ingrowth
biointegration.
Our
results
highlight
potential
nanocellulose
as
safe
commercial
meshes.
However,
fragmentation
observed
for
nanofibril
meshes
suggests
need
measures
optimize
their
preparation.
