Journal of Pharmaceutical Investigation, Journal Year: 2023, Volume and Issue: 53(5), P. 643 - 665
Published: Aug. 9, 2023
Language: Английский
ACS Biomaterials Science & Engineering, Journal Year: 2021, Volume and Issue: 7(6), P. 2177 - 2191
Published: April 20, 2021
Local drug delivery systems composed of biomaterials and osteogenic substances provide promising strategies for the reconstruction large bone defects. In recent years, simvastatin has been studied extensively its pleiotropic effects other than lowering cholesterol, including ability to induce osteogenesis angiogenesis. Accordingly, several studies incorporated have performed demonstrate feasibility such in enhancing regeneration. Therefore, this review explores molecular mechanisms by which affects metabolism The concentrations that promote differentiation are analyzed. Furthermore, we summarize discuss a variety simvastatin-loaded use different loading methods materials. Finally, current shortcomings future development directions summarized. This provides various advanced design simvastatin-incorporated can enhance
Language: Английский
Citations
40
Chemical Engineering and Processing - Process Intensification, Journal Year: 2021, Volume and Issue: 168, P. 108548 - 108548
Published: July 18, 2021
Language: Английский
Citations
33
Medical Oncology, Journal Year: 2023, Volume and Issue: 40(8)
Published: July 6, 2023
Language: Английский
Citations
14
Materials & Design, Journal Year: 2022, Volume and Issue: 222, P. 111045 - 111045
Published: Aug. 9, 2022
Biomaterial implantation for bone defect repair is a complex cascade reaction process, which mainly includes early inflammatory response and subsequent osteogenic repair. In this work, quercetin / nano-hydroxyapatite poly (glycolide-co-epsilon-caprolactone) (Que/n-HA/PGCL) nanocomposite microspheres were successfully prepared by airflow shearing method, possessing interconnected porous structure with unique "eyeball-like" surface morphology. The encapsulation efficiency of reaches as high 80 % Que release was stable continuous, only released 7.5 at 120 h in the 4 wt% group. Moreover, Que-loaded triggered positive immunomodulation via upregulation M2 macrophage polarization evidenced decreased expression pro-inflammatory cytokines TNF-α, iNOS increased anti-inflammatory Arg1, IL-10 RAW264.7 cells, beneficial to BMSCs differentiation co-culture system. Meanwhile, capability directly promote osteo-differentiation manifested Runx2, ALP, OPN, OCN gene increase markers. Furthermore, assessment Que/n-HA/PGCL vivo confirmed desirable contributed efficient excellent osteo-differentiation. Thus, could serve potential functional filling materials repair, be applied drug delivery platform future clinical applications.
Language: Английский
Citations
21
International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 226, P. 485 - 495
Published: Dec. 12, 2022
Language: Английский
Citations
20
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 257, P. 128299 - 128299
Published: Nov. 25, 2023
Language: Английский
Citations
10
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140280 - 140280
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(6), P. 8771 - 8793
Published: Jan. 30, 2025
Cultured meat aims to produce mass by culturing cells and tissues based on the muscle regeneration mechanism, is considered an alternative raising slaughtering livestock. Hydrogel building blocks are commonly used as substrates for cell culture in tissue engineering cultured because of their high water content, biocompatibility, similar three-dimensional (3D) environment cellular niche vivo. With characteristics precise manipulation fluids, microfluidics exhibits advantages fabrication with different structures components, which have been widely applied regeneration. Microfluidic show promising prospects field meat; however, few reviews application microfluidic published. This review outlines recent status use meat. Starting introduction materials construction, we then describe diverse fabricated blocks, including microspheres, microfibers, microsphere-microfiber hybrid systems. Next, stacking strategies construction highlighted detail. Finally, challenges future developing discussed.
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(41), P. 8357 - 8374
Published: Jan. 1, 2022
Microfluidics has been applied to fabricate high-performance functional materials contributing all physiological stages of wound healing. The advances microfluidic-based for healing have summarized.
Language: Английский
Citations
16
Biomedical Materials, Journal Year: 2023, Volume and Issue: 18(5), P. 055023 - 055023
Published: Aug. 15, 2023
Abstract Gelatin methacrylate (GelMA) hydrogels have been widely used in tissue engineering because of their excellent biological and physical properties. Here, we a microfluidic flow-focusing chip based on polymethyl to fabricate cell-laden GelMA hydrogel microspheres. Structures the throat region photo crosslinking chip, flow rate ratio oil phase, concentration were optimized obtain stable suitable size Cell-laden microspheres can be cryopreserved by slow freezing rapid freezing. The survival encapsulated cells after was significantly higher than that unencapsulated cells. There no significant difference between results with 5% DMSO traditional suspended 10% DMSO. It demonstrates possibility itself replace some cryoprotective agents has protective effect Our study provides new ideas optimize for cell cryopreservation, facilitating off-the-shelf availability tissue-engineered constructs.
Language: Английский
Citations
7