Manufacturing and Biological Potential of Saliva‐Loaded Core‐Sheath Pressure‐Spun Polymeric Fibers
Vansh Thukral,
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Nanang Qosim,
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Andre Kurniawan
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et al.
Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
The
rich
array
of
antimicrobial
components
in
saliva
offers
alternative
treatments
for
drug‐resistant
bacteria.
One
therapeutic
challenge
associated
with
the
effective
delivery
salivary
is
quick
degradation
proteins
outside
oral
environment.
In
this
study,
polyethylene
oxide
(sheath)
and
polycaprolactone
(core)
based
fibers
are
successfully
synthesized
using
pressurized
gyration
technique.
Six
different
pressure‐spun
produced.
These
created
by
varying
quantity
artificial
sheath
layer.
This
unique
methodology
embedding
within
fiber
exhibits
enhanced
bacterial
inhibition
against
Escherichia
coli
Staphylococcus
aureus
80%
78%
efficiency,
respectively.
study
showcases
a
novel
technique
promoting
wound
healing,
utilizing
core‐sheath
fibers,
which
have
tremendous
potential
because
their
superior
properties,
while
also
aiding
process
epithelialization.
vitro,
cytotoxicity
test
results
showed
that
there
no
cytotoxic
effect
on
fibroblast
cell
line.
As
result,
it
evaluated
produced
meshes
can
be
ideal
dressing
material,
considering
lack
toxic
effects
high
antibacterial
activity
levels.
Language: Английский
Evaluation of growth behavior of lactic acid bacteria isolated from kimchi via kinetic modeling
LWT,
Journal Year:
2024,
Volume and Issue:
204, P. 116463 - 116463
Published: July 1, 2024
Lactic
acid
bacteria
(LAB)
are
critical
in
kimchi
fermentation.
This
study
determined
the
effect
of
temperature
on
growth
11
predominant
LAB
(five
psychrotrophic
and
six
mesophilic
strains)
isolated
from
analyzed
their
behavior
using
a
kinetic
model
to
understand
changes
communities
during
The
modified
Gompertz
was
more
suitable
for
rather
than
logistic
terms
RMSE,
AICc,
R2,
adjusted
Af
Bf.
Latilactobacillus
sakei
KCKM
0001
Leuconostoc
mesenteroides
0008
rapidly
grew
at
all
temperatures
(5,
10,
15,
20,
25,
30,
37
°C)
among
strains
characteristics
model.
Additionally,
active
that
strains,
excluding
L.
Leu.
fermentation
5–10
°C.
differences
observed
lag
phase
maximum
specific
rate
each
showed
trend
consistent
with
previously
reported
dominant
temperatures.
predictive
modeling
results
could
be
explained
by
different
Language: Английский
Design and Fabrication of Sustained Bacterial Release Scaffolds to Support the Microbiome
Anne Marie Klein,
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Nanang Qosim,
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Gareth R. Williams
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et al.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1066 - 1066
Published: Aug. 14, 2024
Fibres
in
the
micro-
and
nanometre
scale
are
suited
to
a
broad
range
of
applications,
including
drug
delivery
tissue
engineering.
Electrospinning
is
manufacturing
method
choice,
but
it
has
some
limitations.
Novel
pressure-driven
fibre-forming
techniques,
like
pressurised
gyration
(PG),
overcome
these
limitations;
however,
compatibility
PG
with
biological
materials
not
yet
been
evaluated
detail.
For
first
time,
this
limitation
was
investigated
by
optimising
for
microbial
cell
processing
incorporating
bacterial
cultures
into
fibrous
polymeric
scaffolds
sustained
release.
Multiple
polymer–solvent
systems
were
trialled,
polyvinylpyrrolidone
(PVP)/phosphate-buffered
saline
(PBS)
25%
w/v,
polyethylene
oxide
(PEO)/PBS
20%
PVP/ethanol
w/v.
Rheological
studies
revealed
surface
tension
PVP/PBS,
PEO/PBS,
be
73.2,
73.9,
22.6
mN/m,
respectively.
Scanning
electron
microscopy
showed
median
fibre
diameters
between
9.8
μm
26.1
μm,
PVP
producing
larger
fibres.
Overnight
Bacillus
subtilis
then
incorporated
chosen
solutions
processed
fibres
using
PG.
The
produced
cell-loaded
incubated
LB
broth
assess
viability
encapsulated
cells.
Colony
counts
post-incubation
PVP/PBS
resulted
60%
growth,
PEO/PBS
led
47%
whereas
did
lead
any
growth.
Based
on
results
gathered
during
study,
can
concluded
that
offers
promising
way
encapsulating
cells
other
sensitive
products
while
having
many
notable
advantages
compared
electrospinning.
This
research
demonstrates
proof
concept
research-based
evidence
showcases
potential
as
key
disruptive
innovation
probiotic
system
design
manufacturing.
Language: Английский
Design Optimization of Pressurized Gyration Technology: Orifice Height Level Effects on Production Rate and Fiber Morphology
Ahmed Alneyadi,
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Angelo Delbusso,
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A. H. Harker
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et al.
Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
Electrospinning
and
pressurized
gyration
are
two
widely
adopted
methods
for
polymeric
fiber
production,
valued
their
simplicity,
versatility,
relatively
low
environmental
impact.
Despite
its
advantages,
electrospinning
has
notable
limitations,
including
production
efficiency
significant
safety
concerns.
Pressurized
gyration,
however,
offers
greater
productivity
a
safer,
more
sustainable
process,
making
it
an
excellent
candidate
industrial
scaling.
To
fully
realize
this
potential,
optimizing
the
process
is
essential
enhancing
achieving
large‐scale
production.
In
study,
effects
of
vessel
orifice
height
on
rate
morphology
in
explored.
A
series
experiments
conducted
using
15
wt.%
polycaprolactone
(PCL)
solution,
with
vessels
identical
diameter
but
differing
heights
7.5,
15,
22.5
mm
tested
under
pressures
0,
0.1,
0.2,
0.3
MPa,
all
at
constant
rotational
speed
13
000
rpm.
The
7.5
demonstrates
highest
pressure
while
increasing
led
to
finer
diameters,
better
alignment,
smaller
beads.
These
findings
underscore
importance
design,
along
solution
parameters,
scaling
up
manufacturing
meet
demands.
Language: Английский
The tailored manufacturing of core (cellulose acetate)-sheath (polyvinylpyrrolidone) polymeric nanofibers for biphasic drug delivery systems using pressure-spinning
Materials & Design,
Journal Year:
2025,
Volume and Issue:
unknown, P. 113939 - 113939
Published: April 1, 2025
Language: Английский
Core-sheath organic-inorganic hybrid electrospun fibers for organophosphorus heterogeneous catalysis
Jorge Fernandes Z. Netto,
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Flávio B. Miguez,
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Samara B. B. B. Bahia
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et al.
Journal of environmental chemical engineering,
Journal Year:
2024,
Volume and Issue:
12(5), P. 113267 - 113267
Published: June 5, 2024
Language: Английский
Cleaner and Sustainable Production of Core–Sheath Polymer Fibres
Polymers,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2357 - 2357
Published: Aug. 20, 2024
The
amalgamation
of
sustainable
practises
throughout
the
fabrication
process
with
advanced
material
engineering
holds
promise
not
only
for
eco-conscious
manufacturing
but
also
promoting
technological
advancements
in
versatile
design
and
application.
Moreover,
innovation
serves
as
a
catalyst
sustainability
initiatives,
driving
enabling
adoption
greener
across
industries.
This
study
investigates
redefining
production
protocol
pressure
spinning
to
produce
core–sheath
polymer
fibres,
deepening
practises.
It
aims
explore
innovative
approaches
such
modifying
parameters,
optimising
solvent
configurations
understanding
fluid
behaviour
curtail
wastage
maintain
minimal
energy
consumption
without
compromising
efficiency.
Utilising
Polyvinylpyrrolidone
(PVP)
core
Polyethylene
oxide
(PEO)
sheath,
rates
up
64
g/h
were
achieved
fibre
diameter
range
3.2
±
1.7
µm
4.6
2.0
µm.
Energy
per
mass
fibres
produced
showed
decreasing
trend
overall
increasing
applied
gas
pressure.
These
findings
highlight
potential
efficient
scalable
applications
various
materials
fields.
Language: Английский