Liquid Metal‐Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair DOI Open Access
Yujie Zhu, Chenchen Song, Dongdong Yao

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(2)

Published: Feb. 1, 2025

The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral injury (PNI). Flexible conductive materials with mechanical properties similar to those biological tissues have been shown better long-term biointegration functionality than rigid materials. In this study, liquid metal (LM)-based polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined exogenous ES repair PNI. PGPL membranes had good hydrophilicity, degradability, properties, its conductivity reached 0.66 ± 0.02 S/m. vitro studies showed that the (2 Hz, 100 mV/cm, 30 min/d) could significantly increase expression neuromarkers a pro-neural differentiation effect. vivo demonstrated NGCs in 200 mV/mm, effectively promote morphological reconstruction functional recovery sciatic rats. At 3 months post-surgery, restored conduction velocity 73.85% 5.45% normal value. LM-based prepared study long defects, which may further expand application LM field tissue engineering.

Language: Английский

Liquid Metal‐Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair DOI Open Access
Yujie Zhu, Chenchen Song, Dongdong Yao

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(2)

Published: Feb. 1, 2025

The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral injury (PNI). Flexible conductive materials with mechanical properties similar to those biological tissues have been shown better long-term biointegration functionality than rigid materials. In this study, liquid metal (LM)-based polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined exogenous ES repair PNI. PGPL membranes had good hydrophilicity, degradability, properties, its conductivity reached 0.66 ± 0.02 S/m. vitro studies showed that the (2 Hz, 100 mV/cm, 30 min/d) could significantly increase expression neuromarkers a pro-neural differentiation effect. vivo demonstrated NGCs in 200 mV/mm, effectively promote morphological reconstruction functional recovery sciatic rats. At 3 months post-surgery, restored conduction velocity 73.85% 5.45% normal value. LM-based prepared study long defects, which may further expand application LM field tissue engineering.

Language: Английский

Citations

2