Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 21, 2024
Abstract
Photothermal
therapy
(PTT)
holds
considerable
clinical
promise.
However,
insufficient
PTT‐induced
tumor
recurrence
and
metastasis
is
an
urgent
practical
problem
that
needs
to
be
solved.
Herein,
a
biomimetic
mesoporous
organosilicon
nano‐system
called
PSAB
designed
precisely
deplete
cancer
stem
cells
(CSCs)
prevent
after
PTT.
The
system
made
up
of
Aggregation‐induced
emission
(AIE)‐active
photothermal
agent,
2TT‐
o
C26B,
SO
2
prodrug,
benzothiazole
sulfinate
(BTS),
within
nanoparticles
(MON)
enclosed
by
exterior
platelet
membrane.
effectively
targets
CSCs
both
in
vitro
vivo
P‐selectin/CD44
interaction.
degradation
MON
subsequent
release
BTS
AIE
molecules
are
facilitated
intracellular
glutathione
(GSH).
Subsequently,
the
acidic
environment
triggers
gas
from
BTS.
This
process
leads
depletion
GSH
elimination.
After
combining
with
therapy,
there
no
significant
or
metastasis.
These
results
indicate
AIE‐mediated
PTT
act
synergistically
offer
unique
approach
for
preventing
PTT,
thus
holding
promise
applications
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(4)
Published: April 25, 2024
Abstract
Copper
is
a
necessary
micronutrient
for
maintaining
the
well-being
of
human
body.
The
biological
activity
organic
ligands,
especially
their
anticancer
activity,
often
enhanced
when
they
coordinate
with
copper(I)
and
(II)
ions.
its
compounds
are
capable
inducing
tumor
cell
death
through
various
mechanisms
action,
including
activation
apoptosis
signaling
pathways
by
reactive
oxygen
species
(ROS),
inhibition
angiogenesis,
induction
cuproptosis,
paraptosis.
Some
copper
complexes
currently
being
evaluated
in
clinical
trials
ability
to
map
hypoxia
cancers,
locally
advanced
rectal
cancer
bulky
tumors.
Several
studies
have
shown
that
nanoparticles
can
be
used
as
effective
agents
chemodynamic
therapy,
phototherapy,
hyperthermia,
immunotherapy.
Despite
promising
copper-based
compounds,
use
subject
certain
limitations.
Elevated
concentrations
may
promote
growth,
metastasis
affecting
cellular
processes.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
28, P. 101217 - 101217
Published: Aug. 24, 2024
Cold
exposure
therapy
(CE),
as
an
inexpensive
method,
has
shown
great
potential
in
cancer
therapy.
Exploring
the
combined
anti-tumor
mechanism
of
CE
and
traditional
therapies
(such
photodynamic
(PDT))
is
exciting
promising.
Here,
a
bionic
aggregation-induced
emission
photosensitizer
system
(named
THL)
designed
for
to
enhance
immunotherapy.
THL
inherits
homologous
targeting
ability
tumor
derived
exosomes,
promoting
enrichment
at
site.
Under
external
illumination,
generates
hydroxyl
radicals
superoxide
anions
through
type
I
PDT.
In
addition,
mice
are
pretreated
with
cold
exposure,
which
promotes
mediated
PDT
reactive
oxygen
species
(ROS)
generation
by
reducing
production
ATP
GSH
tissue.
This
combination
increases
ROS
within
tumor,
inhibits
growth
distant
tumors,
recurrent
rechallenged
tumors
number
cytotoxic
CD8+T
cells
memory
T
cells.
Compared
alone,
shows
greater
advantages
The
strategy
provides
new
ideas
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Copper
plays
a
pivotal
role
in
human
physiology,
particularly
oncology,
acting
both
as
facilitator
of
progression
and
also
potential
avenue
for
advanced
therapeutic
approaches.
Maintaining
copper
homeostasis
is
crucial.
The
dysregulation
implicated
tumor
growth
through
its
involvement
critical
processes
angiogenesis,
proliferation,
metastasis.
elevation
level
the
microenvironment
(TME)
activates
oncogenic
pathways
to
drive
neovascularization
sustained
malignancies.
However,
same
reliance
on
offers
unique
weakness
that
can
be
leveraged
innovative
interventions.
recent
advances
nanomedicine
enable
synthesis
nanostructures
help
modulate
with
precision
offering
multifaceted
approaches
copper‐based
cancer
therapy
controlled
release
mechanism,
optimized
structures
induce
cuproptosis,
selective
eradication
cells
minimum
systemic
toxicity.
This
review
explores
dual
biology,
emphasizing
contribution
tumors
emerging
application
targeted
therapy.
highlights
harnessing
therapies
their
transformative
from
bench
bed
side
novel,
highly
effective,
clinical
safety.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
Exploration,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
ABSTRACT
Nanozyme‐based
immunogenic
cell
death
(ICD)
inducers
that
effectively
induce
a
strong
immune
response
via
enzyme‐like
process
have
attracted
great
attention,
but
how
to
ensure
controllable
active
sites
and
maximize
site
utilization
remains
problem.
Here,
we
report
structurally
well‐defined
highly
functional
single‐site
copper(I)
nanomodulators
termed
CuNTD,
constructed
by
precisely
anchoring
atomically
dispersed
self‐assembly
S‐Cu(I)‐S
onto
two‐dimensional
Ti
3
C
2
surface.
Leveraging
Cu
+
with
higher
catalytic
efficiency
than
2+
,
CuNTD
generates
reactive
oxygen
species
(ROS)
storms
through
photothermal‐enhanced
cascade
catalysis,
further
inducing
mitochondrial
dysfunction,
ferroptosis
cuproptosis.
Multifunctional
triggers
ICD
cascade‐regulatory
pathways
of
photothermal‐amplified
ROS
storms,
cuproptosis
ferroptosis,
promoting
dendritic
maturation
while
reducing
monotherapies
side
effects
resistance.
In
vivo,
combined
FDA‐approved
immunoadjuvants
significantly
prolong
the
survival
mice.
With
its
demonstrated
biosafety
high
as
an
inducer,
this
study
provides
promising
framework
for
advancing
augmented
tumor
immunotherapy
significant
clinical
potential.
