Development and Characterization of Thermoresponsive Double‐Network Nanocomposite Hydrogel for Bone Tissue Engineering DOI Creative Commons
Abhishek Indurkar, Kristaps Rubenis, Aldo R. Boccaccını

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract In this study, a thermoresponsive double‐network (DN) nanocomposite hydrogel is developed. The primary network comprises Pluronic P123, while the secondary gelatinmethacrylate (GELMA) and polyacrylamide (PAM). A systematic approach adopted to develop DN hydrogels. Initially, impact of P123 concentrationon mechanical properties PAM‐GELMA investigated. Results from tensile strength oscillatory shear tests reveal that an increasing concentration has marginal effect on storage modulus significantly reducing loss hydrogel, thereby improving properties. Notably, DN3 containing 7.5w/v% in exhibits osteoid matrix‐like To further enhance properties, citrate‐containing amorphous calcium phosphate (ACP_CIT) incorporated at varying concentrations. At lower ACP_CIT (0.75 w/v%), DN3‐ACP0.75 are notably enhanced. Incorporating (DN3‐ACP0.75) decreases creep strain, rapid stress relaxation, reduced water uptake capacity maintaining behavior. Finally, vitro analysis confirms cytocompatibility hydrogels with MC3T3‐E1 cells, indicating potential use bone tissue engineering.

Language: Английский

Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials DOI Creative Commons
Zhen Wang, Yanan Sun, Chen Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 14, 2024

Introduction Bone tissue engineering (BTE) provides an effective repair solution by implanting osteoblasts or stem cells into biocompatible and biodegradable scaffolds to promote bone regeneration. In recent years, the rapid development of 3D bioprinting has enabled its extensive application in fabricating BTE scaffolds. Based on three-dimensional computer models specialized “bio-inks,” this technology offers new pathways for customizing This study reviews current status future prospects scaffold materials bioprinting. Methods literature review collected studies bioprinting, analyzing advantages limitations various printing, including bioceramics, metals, natural polymers, synthetic polymers. Key characteristics like biocompatibility, mechanical properties, degradation rates these were systematically compared. Results The highlights diverse performances used Bioceramics exhibit excellent biocompatibility but suffer from brittleness; metals offer high strength may induce chronic inflammation; polymers are yet have poor while strong tunability produce acidic by-products during degradation. Additionally, integrating with composite could enhance presenting viable solutions challenges. Discussion summarizes advances applications, exploring strengths proposing material combinations improve performance. By optimizing selection combinations, shows promise creating customized scaffolds, offering a technical route clinical applications BTE. research unique perspective theoretical support advancing regeneration, outlining directions development.

Language: Английский

Citations

6
3D printing tissue-engineered scaffolds for auricular reconstruction DOI Creative Commons

Shuyi Gao,

Tianqi Nie, Ying Lin

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101141 - 101141

Published: July 2, 2024

Congenital microtia is the most common cause of auricular defects, with a prevalence approximately 5.18 per 10,000 individuals. Autologous rib cartilage grafting leading treatment modality at this stage reconstruction currently. However, harvesting may lead to donor site injuries, such as pneumothorax, postoperative pain, chest wall scarring, and deformity. Therefore, in pursuit better graft materials, biomaterial scaffolds great histocompatibility, precise control morphology, non-invasiveness properties are gradually becoming new research hotspot reconstruction. This review collectively presents exploit application 3D printing scaffold Although tissue-engineered ear still faces challenges before it can be widely applied patients clinical settings, its long-term effects have yet evaluated, we aim provide guidance for future directions will ultimately benefit translational tissue engineering biomaterials defects.

Language: Английский

Citations

4
Multifunctional chitosan-hydroxyapatite-polyphenol nanoparticles from 3D printed bone scaffolds: Controlled release and therapeutic properties DOI

Jiafang Chen,

Liang Qiao, Shuyi Zhao

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113738 - 113738

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metal ion-crosslinking multifunctional hydrogel microspheres with inflammatory immune regulation for cartilage regeneration DOI Creative Commons
Zhuoming Xu, Jun Ma,

Hanyin Hu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 28, 2025

Introduction Osteoarthritis (OA) is a degenerative disease of the joints characterized by cartilage degradation and synovial inflammation. Due to complex pathogenesis OA, multifaceted therapies that modulate inflammatory immune microenvironmental disturbances while promoting regeneration are key control progression OA. Methods Herein, multifunctional nanoparticle (DIC/Mg-PDA NPs) was constructed successfully metal chelation effect between Mg 2+ catecholamine bond from dopamine, followed amidation with diclofenac (DIC), which then prepared into an injectable hydrogel microsphere (DIC/Mg-PDA@HM) immune-regulating cartilage-repairing abilities through microfluidic technology for treatment osteoarthritis. Results discussion The sustained release composite microspheres achieved regulation converting macrophages M1 M2 promoted differentiation BMSCs. Moreover, enhanced DIC polydopamine (PDA) effectively downregulated factors, finally OA therapy. In addition, in vivo MRI tissue section staining model proved significant efficacy on conclusion, these novel demonstrated promising prospect multidisciplinary repairing

Language: Английский

Citations

0
Evaluation of the Characteristics of Digital Light Processing 3D-Printed Magnesium Calcium Phosphate for Bone Regeneration DOI Creative Commons
Peng Zhang, Meiling Zhang, Yeon‐Gil Jung

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 139 - 139

Published: April 14, 2025

Recent advancements in three-dimensional (3D) printing technology, particularly digital light processing (DLP) 3D printing, have enabled the customization of bone substitutes with specific shapes that match defect sizes and geometries. Magnesium calcium phosphate (MCP) has gained considerable attention due to its strong mechanical properties, degradability, ability promote regeneration. In this study, we prepared MCP samples five different molar ratios via DLP printing. We analyzed physicochemical properties these groups, including phase compositions microstructures, which were examined using X-ray diffraction scanning electron microscopy, respectively. Additionally, assessed effects on material density shrinkage. Biaxial flexural strength degradation rate evaluated; biological through WST-8 analysis alkaline phosphatase activity assays. Among tested samples, MCP1/1 exhibited highest strength. A higher proportion magnesium corresponded an increased rate. Cell response observations assay indicated cell proliferation was better group than other groups days 4 7 culturing. Alkaline assays demonstrated phosphate. Our findings suggest can be used effectively bone-tissue-engineering applications.

Language: Английский

Citations

0
Application and Potential of Nanobiomaterials in Bone Regeneration DOI
Wenting Zhou,

Rui He,

Ran Du

et al.

Journal of Biomaterials and Tissue Engineering, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 20

Published: Jan. 1, 2024

This review thoroughly investigates the latest developments and challenges of nanobiomaterials in bone regeneration. It begins by elucidating fundamental properties nanomaterials their unique role promoting cell proliferation differentiation. The further explores innovative applications enhancing regeneration efficiency, reducing immune reactions toxicity, while also discussing current technological limitations future possibilities. Conclusively, article predicts treatments, especially highlighting potential personalized medicine bioprinting technologies.

Language: Английский

Citations

1
Current status and challenges of shape memory scaffolds in biomedical applications DOI Creative Commons
Haoming Wu,

Shuhao Yang,

Jiuhong Li

et al.

MedComm – Biomaterials and Applications, Journal Year: 2024, Volume and Issue: 3(3)

Published: Sept. 1, 2024

Abstract The rapid evolution of clinical medicine, materials science, and regenerative medicine has rendered traditional implantable scaffolds inadequate for addressing the complex therapeutic demands various diseases. Currently, in practice are mainly made metal, with disadvantages high stiffness, poor toughness, low deformation. This paper offers a thorough review shape memory (SMSs), emphasizing their distinctive self‐recovery adaptive functionalities that enhance compatibility injured tissues, surpassing capabilities conventional metallic biomaterials. It delves into limitations current requisite performance metrics effective implants outlines essential fabrication methods SMSs. Moreover, we enumerate biomedical applications SMMs different response types, including thermology‐responsive, water‐responsive, light‐responsive. discussion extends to burgeoning SMSs engineering, utility bone tissue cardiovascular stenting, tubular structures, cardiac patches, which underscore potential minimally invasive procedures dynamic interactions. concludes an analysis challenges prospects, providing valuable insights developing applying sector.

Language: Английский

Citations

1
Bone Tissue Engineering Scaffold Film with Controlled Release of Tea Polyphenol-Magnesium Nanoformulations to Prevent Bacterial Infection DOI
Jian He,

Jiafang Chen,

Jiancheng Liu

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Language: Английский

Citations

1
Polysaccharide Composite Hydrogel Encapsulated Retinoic Acid and Nano Se Doped Cap to Enhance in Situ Mineralization and Osteoimmunomodulation for Bone Regeneration DOI

Ritu Singhmar,

Yumi Son,

Yoo Jung Joo

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Development and Characterization of Thermoresponsive Double‐Network Nanocomposite Hydrogel for Bone Tissue Engineering DOI Creative Commons
Abhishek Indurkar, Kristaps Rubenis, Aldo R. Boccaccını

et al.

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract In this study, a thermoresponsive double‐network (DN) nanocomposite hydrogel is developed. The primary network comprises Pluronic P123, while the secondary gelatinmethacrylate (GELMA) and polyacrylamide (PAM). A systematic approach adopted to develop DN hydrogels. Initially, impact of P123 concentrationon mechanical properties PAM‐GELMA investigated. Results from tensile strength oscillatory shear tests reveal that an increasing concentration has marginal effect on storage modulus significantly reducing loss hydrogel, thereby improving properties. Notably, DN3 containing 7.5w/v% in exhibits osteoid matrix‐like To further enhance properties, citrate‐containing amorphous calcium phosphate (ACP_CIT) incorporated at varying concentrations. At lower ACP_CIT (0.75 w/v%), DN3‐ACP0.75 are notably enhanced. Incorporating (DN3‐ACP0.75) decreases creep strain, rapid stress relaxation, reduced water uptake capacity maintaining behavior. Finally, vitro analysis confirms cytocompatibility hydrogels with MC3T3‐E1 cells, indicating potential use bone tissue engineering.

Language: Английский

Citations

0