Association of SIRT6 Expression With Risk of Pneumonitis Induced by Radiotherapy in Cancer Patients DOI Creative Commons

Fengyuan Yu,

Zheng Gong, Yuan Li

et al.

Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Thoracic tumours represent a significant proportion of malignant cancers. While radiotherapy (RT) improves prognosis, it can also lead to side effects such as radiation-induced pneumonitis (RP). Since SIRT6 is involved in DNA repair, energy metabolism and inflammation, this study aims investigate the expression lymphocytes potential biomarker therapeutic target for RP. This included 170 patients diagnosed with thoracic tumours, all whom underwent RT. RP was evaluated classified severe (SRP) lower non-severe (NSRP). Analyses were performed using SPSS version 26.0 R. Among study, 124 developed NSRP, 46 experienced SRP. The univariate analysis showed that (cOR, 0.33, 95%CI, 0.18-0.97 before RT 0.31, 0.19-0.98 after RT), clinical factors, dosimetric parameters haematological/serological associated SRP Our multivariable logistic regression significantly risk (aOR, 0.32, 0.15-0.96) 0.18-0.99) adjustment other confounders. Moreover, receiver operating characteristic curve revealed combined model exhibited superior predictive capability compared any single predictor (overall AUC, 0.93, 0.90-0.97 0.91, 0.87-0.96 RT). alone or combination factors an increased SRP, suggesting novel approach prevention treatment radiation practice.

Language: Английский

Unraveling the tumor microenvironment of esophageal squamous cell carcinoma through single-cell sequencing: A comprehensive review DOI

Lingyu Qi,

Jiaxin Wang, Shuang Hou

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189264 - 189264

Published: Jan. 1, 2025

Language: Английский

Citations

1
Cancer-associated fibroblasts in hepatocellular carcinoma: heterogeneity, mechanisms and therapeutic targets DOI
Yutong Li, Mawieh Hamad, Eyad Elkord

et al.

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

1
Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications DOI Creative Commons
Zhengjun Lin, Guoqing Li, Ke Jiang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 7, 2024

Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs critically involved shaping structure function microenvironment with numerous functions regulating behaviours, such as metastasis, invasion, epithelial-mesenchymal transition (EMT). can interact extensively cells by producing extracellular vesicles (EVs), multiple secreted factors, metabolites. Notably, CAF-derived EVs been critical mediators therapy resistance, constitute novel targets biomarkers management. This review aimed to summarize biological detailed molecular mechanisms mediating resistance chemotherapy, targeted agents, radiotherapy, immunotherapy. We also discussed therapeutic potential clinical management, thereby providing strategy for enhancing efficacy improving

Language: Английский

Citations

8
Targeting extracellular matrix interaction in gastrointestinal cancer: Immune modulation, metabolic reprogramming, and therapeutic strategies DOI

Jiyifan Li,

Wenxin Zhang, Lu Chen

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189225 - 189225

Published: Nov. 1, 2024

Language: Английский

Citations

4
Cancer‑associated fibroblasts: a pivotal regulator of tumor microenvironment in the context of radiotherapy DOI Creative Commons

Linhui Zheng,

Wenqi Cai, Ke Yuan

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 20, 2025

In the course of tumor treatment, radiation therapy (RT) not only kills cancer cells, but also induces complex biological effects in non-malignant cells around cells. These such as angiogenesis, changes stromal composition and immune cell infiltration remodel microenvironment (TME). As one major components TME, Cancer‑associated fibroblasts (CAFs) are involved tumorigenesis, progression, recurrence, metastasis regulate tumor-associated microenvironment. CAFs or have intercellular communication context radiation. Main content. Different cellular precursors, spatial location differences, absence specific markers, advances single-cell sequencing technology gradually made abundant heterogeneity well known. Due to unique radioresistance properties, can survive under high doses ionizing However, induce phenotypic functional further act on promote inhibit progression. To date, effect RT irradiated progression TME still defined. this review, we review origin, phenotypic, describe CAFs, focusing mutual crosstalk between after We discuss emerging strategies for targeted therapy.

Language: Английский

Citations

0
Association of SIRT6 Expression With Risk of Pneumonitis Induced by Radiotherapy in Cancer Patients DOI Creative Commons

Fengyuan Yu,

Zheng Gong, Yuan Li

et al.

Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Thoracic tumours represent a significant proportion of malignant cancers. While radiotherapy (RT) improves prognosis, it can also lead to side effects such as radiation-induced pneumonitis (RP). Since SIRT6 is involved in DNA repair, energy metabolism and inflammation, this study aims investigate the expression lymphocytes potential biomarker therapeutic target for RP. This included 170 patients diagnosed with thoracic tumours, all whom underwent RT. RP was evaluated classified severe (SRP) lower non-severe (NSRP). Analyses were performed using SPSS version 26.0 R. Among study, 124 developed NSRP, 46 experienced SRP. The univariate analysis showed that (cOR, 0.33, 95%CI, 0.18-0.97 before RT 0.31, 0.19-0.98 after RT), clinical factors, dosimetric parameters haematological/serological associated SRP Our multivariable logistic regression significantly risk (aOR, 0.32, 0.15-0.96) 0.18-0.99) adjustment other confounders. Moreover, receiver operating characteristic curve revealed combined model exhibited superior predictive capability compared any single predictor (overall AUC, 0.93, 0.90-0.97 0.91, 0.87-0.96 RT). alone or combination factors an increased SRP, suggesting novel approach prevention treatment radiation practice.

Language: Английский

Citations

0