Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology DOI Creative Commons
Daniel Ejim Uti, Item Justin Atangwho, Esther Ugo Alum

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

Iron‐Deficiency Anemia Elevates Risk of Diabetic Kidney Disease in Type 2 Diabetes Mellitus DOI Creative Commons
Bin Huang, Wenjie Wen, Shandong Ye

et al.

Journal of Diabetes, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 1, 2025

ABSTRACT Objective This study aims to explore the link between iron deficiency anemia (IDA) and diabetic kidney disease (DKD) assess safety of supplementation. It also investigates key mechanisms molecules involved in deficiency's role development. Methods A retrospective analysis was conducted on 1,398 T2DM patients using propensity score matching identify risk factors for DKD. Mendelian randomization (MR) used causal relationships IDA, supplementation, liver content, The GSE27999 dataset analyzed examine how an iron‐deficient diet affects kidney‐related gene expression. Key pathways were identified through GSEA, GO/KEGG, PPI analysis. Results Retrospective data showed a correlation hemoglobin levels DKD risk. Logistic regression confirmed that IDA increased independently other factors. MR revealed DKD, with no significant effect from 580 differentially expressed genes, enriched like cytokine signaling, oxidative biology, small molecule transport. highlighted 10 hub including Cyp2d26 Fgf4. Conclusion increases susceptibility possibly stress altered However, supplementation does not appear increase

Language: Английский

Citations

0
Absence of Astrocytic Ceruloplasmin Reverses the Senescence Process with Aging of Learning and Memory Abilities DOI Creative Commons
Zhong-Da Li,

Shaomeng Kang,

Haiyan Li

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103611 - 103611

Published: March 1, 2025

Ceruloplasmin (CP) is a multi-copper ferroxidase mainly synthesized by liver, secreted into the peripheral blood, playing critical role in regulating iron homeostasis. In central nervous system (CNS), CP expressed astrocytes plays an important transportation of from blood across blood-brain barrier (BBB) brain. Our previous study showed that conditional knockout astrocytic with Cre-LoxP (CpGfapcKO) not only improved learning and memory abilities elderly mice, but also impaired young mice. order to further investigate effects on aging, we constructed mice model tamoxifen-induced astrocyte specific CP, induced at 12 months old, observed mouse 18 old. We were delighted found ablation tamoxifen old could similarly enhance learning, recognition 18-month-old Iron deposition hippocampus associated aging was mitigated, leading reduction oxidative stress. The MAPK/JNK pathway exhibited attenuation, while PI3K/Akt/GSK3 enhancement. This combination expected result phosphorylation level MYC elevation nuclear translocation MYC, which might then contribute reduced cellular senescence. Additionally, ROS/MAPK/Erk ROS/MAPK/p38 pathways-dependent cell apoptosis diminished. hallmarks Alzheimer's Disease (AD) all significantly reduced. Ultimately, alleviated senescence along AD-related markers, coincided improvement memory, abilities. These findings elucidated brain metabolism, offering novel target strategy for prevention treatment neurodegenerative diseases, such as AD aging.

Language: Английский

Citations

0
Ferroptosis contributed to endoplasmic reticulum stress in preterm birth by targeting LHX1 and IRE-1 DOI

Liyin Qiu,

Hui Liu,

Shali Chen

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111777 - 111777

Published: March 1, 2025

Language: Английский

Citations

0
The roles and mechanisms of CDGSH iron-sulfur domain 1 in kainic acid-induced mitochondrial iron overload, dysfunction and neuronal damage DOI
Jing Wang, Shuo Li,

Haidong Xu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118067 - 118067

Published: April 24, 2025

Language: Английский

Citations

0
Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology DOI Creative Commons
Daniel Ejim Uti, Item Justin Atangwho, Esther Ugo Alum

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

Citations

0