Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 955 - 955

Published: May 8, 2024

Digestive cancers are among the leading causes of cancer death in world. However, mechanisms development and progression not fully understood. Accumulating evidence recent years pointing to bidirectional interactions between gut dysbiosis a specific type gastrointestinal is shedding light on importance this “unseen organ”—the microbiota. This review focuses local role microbiota imbalance different digestive tract organs annexes related carcinogenic mechanisms. Microbiota modulation, either by probiotic administration or dietary changes, plays an important future therapies various cancers.

Language: Английский

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Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract Cancer is a major cause of death globally, and traditional treatments often have limited efficacy adverse effects. Immunotherapy has shown promise in various malignancies but less effective tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) been associated favorable response to immunotherapy improved survival cancer patients. However, the immunological mechanisms clinical significance TLS malignant are not fully understood. In this review, we elucidate composition, neogenesis, immune characteristics tumors, as well inflammatory development. An in‐depth discussion unique TLSs lung cancer, breast melanoma, soft tissue sarcomas will be presented. Additionally, therapeutic implications TLS, including its role marker prognosis, strategies promote formation maturation explored. Overall, aim provide comprehensive understanding tumor microenvironment suggest potential interventions for treatment.

Language: Английский

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Roles of tertiary lymphatic structures in gastric cancer

Shijie huaren xiaohua zazhi, Journal Year: 2025, Volume and Issue: 33(3), P. 178 - 182

Published: March 28, 2025

Language: Английский

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Tertiary lymphoid structures associated with improved survival and enhanced antitumor immunity in acral melanoma

npj Precision Oncology, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 9, 2025

Understanding the impact of tertiary lymphoid structures (TLSs) on acral melanoma (AM) and tumor microenvironment (TME) is critical. We analyzed TLS features in primary AM lesions from 46 patients identified intratumoral TLSs (intra-TLSs) 25 patients. Intra-TLS presence was significantly associated with improved overall survival. Hematoxylin eosin staining multiplex immunofluorescence revealed increased T-cell CD8+ infiltration fewer tumor-associated macrophages TME intra-TLS Transcriptomic analysis a TLS-associated Th1/B-cell gene set as predictor survival immunotherapy response. These findings highlight prognostic value intra-TLSs AMs suggest that targeting formation could enhance efficacy.

Language: Английский

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Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 23, 2024

Solid carcinomas are often highly heterogenous cancers, arising from multiple epithelial cells of origin. Yet, how the cell origin influences response tumor microenvironment is poorly understood. Lung adenocarcinoma (LUAD) arises in distal alveolar epithelium which populated primarily by type I (AT1) and II (AT2) cells. It has been previously reported that

Language: Английский

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