Journal of Applied Genetics, Journal Year: 2024, Volume and Issue: 65(3), P. 473 - 492
Published: May 16, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 18, 2024
Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.
Language: Английский
Citations
35
MedComm, Journal Year: 2024, Volume and Issue: 5(2)
Published: Feb. 1, 2024
Abstract Epigenetic modifications are defined as heritable changes in gene activity that do not involve the underlying DNA sequence. The oncogenic process is driven by accumulation of alterations impact genome's structure and function. Genetic mutations, which directly disrupt sequence, complemented epigenetic modulate expression, thereby facilitating acquisition malignant characteristics. Principals among these shifts methylation histone mark patterns, promote tumor development metastasis. Notably, reversible nature alterations, opposed to permanence genetic changes, positions machinery a prime target discovery novel therapeutics. Our review delves into complexities regulation, exploring its profound effects on initiation, metastatic behavior, metabolic pathways, microenvironment. We place particular emphasis dysregulation at each level modulation, including but limited to, aberrations enzymes responsible for modification, subunit loss or fusions chromatin remodeling complexes, disturbances higher‐order structure. Finally, we also evaluate therapeutic approaches leverage growing understanding dysregulation, offering new avenues cancer treatment.
Language: Английский
Citations
17
Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(19-20), P. 640 - 651
Published: July 23, 2024
Oral squamous cell carcinoma (OSCC) is a highly unpredictable disease with devastating mortality rates that have not changed over the past decades, in face of advancements treatments and biomarkers, which improved survival for other cancers. Delays diagnosis are frequent, leading to more disfiguring poor outcomes patients. The clinical challenge lies identifying those patients at highest risk developing OSCC. epithelial dysplasia (OED) precursor OSCC variable behavior across There no reliable clinical, pathological, histological, or molecular biomarker determine individual OED Similarly, there robust biomarkers predict treatment This review aims highlight artificial intelligence (AI)-based methods develop predictive transformation response. Biomarkers such as S100A7 demonstrate promising appraisal malignant OED. Machine learning-enhanced multiplex immunohistochemistry workflows examine immune patterns organization within tumor microenvironment generate outcome predictions immunotherapy. Deep learning (DL) an AI-based method using extended neural network related architecture multiple "hidden" layers simulated neurons combine simple visual features into complex patterns. DL-based digital pathology currently being developed assess outcomes. integration machine epigenomics epigenetic modification diseases improve our ability detect, classify, associated marks. Collectively, these tools showcase discovery technology, may provide potential solution addressing current limitations predicting behavior, both challenges must be addressed order survival.
Language: Английский
Citations
5
MedComm, Journal Year: 2025, Volume and Issue: 6(3)
Published: March 1, 2025
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, predominantly associated with chronic hepatitis B virus (HBV) and C (HCV) infections. These infections drive persistent liver inflammation, culminating in cellular dysregulation, fibrosis, cancer. Despite advancements targeted therapies, drug resistance the lack reliable biomarkers for patient stratification still terribly hinder treatment viral HCC. To this end, review delves into intricate mechanisms underlying malignant transformation to HCC, including integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, immune escape, abnormal signaling pathways, highlighting their complex interactions synergies. Cutting-edge preclinical clinical HCC management, lifestyle immunotherapies, gene-based approaches, innovative treatments, are further investigated, particular priority given therapeutic potential future applications overcoming current limitations. By synthesizing recent scientific insights, aims deepen understanding pathogenesis context hepatitis, paving way novel targets personalized strategies, ultimately improving outcomes.
Language: Английский
Citations
0
Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)
Published: March 1, 2025
ABSTRACT Phytochemicals are bioactive compounds found in plants that play a key role promoting health and preventing diseases. Present fruits, vegetables, grains, seed oils, these considered safe for consumption due to the co‐evolution adaptation between mammals plants. Due their wide‐ranging biological effects, they have attracted considerable research interest. This comprehensive review explores mechanisms of action, benefits, applications dietary phytochemicals, with particular focus on groups such as polyphenols, flavonoids, carotenoids. Research shows phytochemicals interact nuclear membrane receptors, influence metabolic pathways, affect epigenetic modifications. Our highlights broad range activities compounds, including antioxidant, antibacterial, anti‐inflammatory, anti‐diabetic, anticancer all which contribute health‐promoting properties. Clinical evidence supports prevention management diseases cardiovascular disorders, conditions, cancer, diets rich being linked lower risk disease. also at cutting edge food preservation, supplements, emerging medical treatments. Additionally, we identified advancements extraction identification techniques, particularly metabolomics, further enhance areas. Despite promising challenges bioavailability, regulatory barriers, need robust clinical trials persist. However, innovative delivery systems like nanoparticles, liposomes, encapsulation offer potential solutions bioavailability by improving absorption stability. The concludes emphasizing personalized nutrition combination therapies benefits while stressing methods, trials, bioavailability.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9339 - 9339
Published: Aug. 28, 2024
Cellular metabolism is crucial for various physiological processes, with folate-dependent one-carbon (1C) playing a pivotal role. Folate, B vitamin, key cofactor in this pathway, supporting DNA synthesis, methylation and antioxidant defenses. In dividing cells, folate facilitates nucleotide biosynthesis, ensuring genomic stability preventing carcinogenesis. Additionally, neurodevelopment, essential neural tube closure central nervous system formation. Thus, dysregulation of can contribute to pathologies such as cancer, severe birth defects, neurodegenerative diseases. Epidemiological evidence highlights folate's impact on disease risk its potential therapeutic target. antifolate drugs that inhibit enzymes 1C strategies targeting receptors are current options. However, cancer complex, varying among types dietary contexts. conditions, including Alzheimer's Parkinson's diseases, deficiency exacerbates cognitive decline through elevated homocysteine levels, contributing neuronal damage. Clinical trials folic acid supplementation show mixed outcomes, underscoring the complexities neuroprotective effects. This review integrates knowledge neurodegeneration, exploring molecular mechanisms, clinical implications, strategies, which provide information advancing treatments.
Language: Английский
Citations
4
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217497 - 217497
Published: Jan. 1, 2025
Language: Английский
Citations
0
Asian Journal of Biological Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 516 - 532
Published: Jan. 23, 2025
Language: Английский
Citations
0
İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, Journal Year: 2025, Volume and Issue: 13(1), P. 169 - 180
Published: Feb. 14, 2025
Post translasyonel modifikasyonların gerçekleştiği endoplazmik retikulumda (ER) işlenmiş protein yükü ile katlanma kapasitesi arasındaki dengenin bozulması sonucu, adaptif ER stresi oluşur ve otofajinin aktif olması beklenir. otofajik bozuklukların kanser ilişkisi belirsizliğini korumaktadır. Bu çalışmada çeşitli hücrelerinde bu yolaklardaki anahtar genlerdeki metilasyon değişikliklerinin araştırılması amaçlanmıştır. Çalışmada (HepG2, MCF-7) sağlıklı hücrelerdeki (MCF-10A) ilgili genlerin düzeyleri RT-PZR tekniği araştırıldı. Çalışmamızda MCF7 genlerinden MAP3K5, ATF6 MAOA’nin DNA düzeylerinin anlamlı şekilde azaldığı XBP1 EIF2AK3 genlerinde ise arttığı belirlendi. HEPG2 MAOA hipometilasyon saptandı. Otofaji yolağı sadece GBA geninde her iki hücrede olduğu sonuçlarla, çoğu genlerinin epigenetik olarak aktivitelerinin değiştirildiği böylece hücrelerin transformasyon sürecini hızlandırıldığı söyleyebiliriz.
Citations
0
MedComm, Journal Year: 2025, Volume and Issue: 6(3)
Published: Feb. 27, 2025
Abstract Liver metastasis is a leading cause of mortality from malignant tumors and significantly impairs the efficacy therapeutic interventions. In recent years, both preclinical clinical research have made significant progress in understanding molecular mechanisms strategies liver metastasis. Metastatic tumor cells different primary sites undergo highly similar biological processes, ultimately achieving ectopic colonization growth liver. this review, we begin by introducing inherent metastatic‐friendly features We then explore panorama conclude three continuous, yet distinct phases based on liver's response to This includes metastatic sensing stage, stress support stage. discuss intricate interactions between various resident recruited cells. addition, emphasize critical role spatial remodeling immune Finally, review advancements challenges faced management Future precise antimetastatic treatments should fully consider individual heterogeneity implement targeted interventions stages
Language: Английский
Citations
0