Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1109 - 1109
Published: Sept. 13, 2024
Oxidative
stress
is
the
result
of
imbalance
between
reactive
oxygen
and
nitrogen
species
(RONS),
which
are
produced
by
several
endogenous
exogenous
processes,
antioxidant
defenses
consisting
molecules
that
protect
biological
systems
from
free
radical
toxicity.
a
major
factor
in
aging
process,
contributing
to
accumulation
cellular
damage
over
time.
biomolecules,
leads
DNA
alterations,
lipid
peroxidation,
protein
oxidation,
mitochondrial
dysfunction
resulting
senescence,
immune
system
tissue
dysfunctions,
increased
susceptibility
age-related
pathologies,
such
as
inflammatory
disorders,
cardiovascular
neurodegenerative
diseases,
diabetes,
cancer.
stress-driven
mutations,
or
methylation
histone
modification,
alter
gene
expression,
key
determinants
tumor
initiation,
angiogenesis,
metastasis,
therapy
resistance.
Accumulation
genetic
epigenetic
damage,
oxidative
contributes,
eventually
unrestrained
cell
proliferation,
inhibition
differentiation,
evasion
death,
providing
favorable
conditions
for
tumorigenesis.
Colorectal,
breast,
lung,
prostate,
skin
cancers
most
frequent
aging-associated
malignancies,
implicated
their
pathogenesis
behavior.
Our
aim
shed
light
on
molecular
mechanisms
link
stress,
aging,
cancers,
highlighting
impact
both
RONS
antioxidants,
provided
diet
exercise,
immunity,
development
an
antitumor
response.
The
dual
role
ROS
physiological
regulators
signaling
responsible
well
its
use
anti-tumor
therapeutic
purposes,
will
also
be
discussed.
Managing
crucial
promoting
healthy
reducing
risk
tumors.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2049 - 2049
Published: Feb. 26, 2025
Lung
cancer
is
one
of
the
most
common
malignant
cancers
in
countries
and
leading
cause
death
among
diseases
worldwide.
Despite
constant
progress
diagnosis
therapy,
survival
rates
patients
diagnosed
with
lung
remain
unsatisfactory.
Numerous
epidemiological
experimental
studies
conducted
as
early
1970s
confirm
that
important
risk
factor
for
development
long-term
smoking,
which
remains
valid
to
this
day.
In
paper,
authors
present
latest
data
on
epidemiology,
pathogenesis,
treatment
molecular
aspects
cancer.
last
decade,
many
alterations
are
effective
have
been
discovered.
adenocarcinoma,
tyrosine
kinase
inhibitors
were
developed
EGFR
mutations
ALK
ROS1
translocations
approved
use
advanced
stage
adenocarcinomas.
case
squamous
cell
carcinoma,
evaluation
these
not
yet
being
used
clinical
practice.
addition,
there
ongoing
concerning
potential
therapeutic
targets,
such
ROS,
MET,
FGFR,
DDR-2
RET.
Constant
diagnostic
methods
gives
rise
hopes
an
improved
prognosis
Dermatological Reviews,
Journal Year:
2025,
Volume and Issue:
6(2)
Published: March 24, 2025
ABSTRACT
Aim
This
study
aims
to
provide
a
comprehensive
analysis
of
keratinocytes,
the
predominant
cell
type
in
epidermis,
by
examining
their
structural,
functional,
and
regulatory
roles
skin
biology.
The
explores
intricate
processes
keratinocyte
differentiation,
proliferation,
immune
interactions,
emphasizing
essential
contributions
homeostasis,
wound
healing,
barrier
integrity.
Additionally,
it
investigates
involvement
keratinocytes
dermatological
disorders
such
as
psoriasis,
atopic
dermatitis,
cancer,
highlighting
pathological
alterations
molecular
mechanisms.
Methods
review
covers
broad
range
studies,
including
vitro
vivo
research
on
biology,
interactions
with
growth
factors,
inflammatory
responses
skin.
It
also
discusses
therapeutic
advancements
biologics
gene
therapy
that
focus
restoring
function
diseases.
Results
highlights
play
pivotal
role
inflammation
regulation
factors
promote
healing
regeneration.
Dysregulation
is
linked
several
diseases,
need
for
targeted
approaches.
Recent
treatments,
biologics,
offer
promising
outcomes
managing
conditions
driven
dysfunction.
Conclusion
primary
aim
this
an
in‐depth
overview
functions
particularly
health,
inflammation,
disease
development.
highlight
latest
strategies
targeting
treatment
Future Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: April 15, 2025
The
challenges
in
drug
discovery
aiming
to
mitigate
cancer
progression
are
the
thrust
area
of
scientific
research
for
several
decades.
Since
advent
heterocyclic
chemistry,
programs
have
made
significant
achievements
that
lead
development
numerous
drugs
with
broad
spectrum
potencies,
contributing
both
diagnostic
and
therapeutic
advancements.
Till
date,
efforts
discover
more
potent
efficient
candidates
underway
minimize
adverse
side
effects
existing
chemotherapeutics.
In
view
above,
small-molecule
agonists
can
interact
different
immune
modulators
like
toll
receptor-7
(TLR-7)
TLR-8
being
investigated
explored.
These
expected
display
profound
effect
on
anti-tumoral
activity
by
enhancing
production
proinflammatory
cytokines.
Recently,
imidazoquinoline
derivatives
proven
TLR
agonist
activities
emerged
as
promising
anticancer
therapeutics.
With
advancements
technology
evolution
new
scopes
discovery,
strategies
adopted,
particularly
help
nanotechnology,
immune-technology,
combination
etc.,
curb
various
types
cancers.
Herein,
novel
therapeutics
imidazoquinolines
reported
last
5
years,
their
structure-activity
relationship
along
important
synthetic
schemes
agonists,
discussed.
