Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages DOI

Ziwen Qiu,

Yingtao Zhong, Zhen‐Ming Lu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Treatment‐induced cell pyroptosis can improve the immunogenicity of breast cancer and enhance efficacy immune checkpoint blockade (ICB), but resultant recruitment immunosuppressive cells impedes systemic anti‐tumor immunity. Herein, a rationally designed self‐adaptor (R@L‐MRS17) is developed to initiate concomitantly reeducate pyroptosis‐recruited macrophages ICB therapy. Of which, R@L‐MRS17 promotes cancer‐specific drug delivery through CD47 recognition, enables plasma membrane targeted photosensitizer insertion hydrophobic electrostatic interactions. Under light excitation, produces reactive oxygen species (ROS) in situ trigger pyroptosis, followed by release pro‐inflammatory factors recruit tumor immunogenicity. Moreover, acid responsiveness facilitates R848 polarize infiltrated into M1 phenotype for active Additionally, capable blocking restore recognition phagocytosis behavior M1‐type against cells. In short, stepwise activation significantly suppresses bilateral growth metastasis combination with αPD‐L1. This study provides self‐adaptable strategy activate immunological cascade, which may spatiotemporally amplify responses cancer.

Language: Английский

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets DOI Creative Commons

Fan Guan,

Ruixuan Wang,

Zhenjie Yi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Language: Английский

Citations

3
Caspase family in autoimmune diseases DOI

Wangzheqi Zhang,

Huang Wu,

Yan Liao

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 24(2), P. 103714 - 103714

Published: Dec. 3, 2024

Language: Английский

Citations

4
Macrophages Unmasked: Their Pivotal Role in Driving Atherosclerosis in Systemic Lupus Erythematosus DOI
Chao Wang,

B Chen,

Xiaochen Yu

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 7, 2025

Language: Английский

Citations

0
The role of pyroptosis in environmental pollutants-induced multisystem toxicities DOI
Rui Xu, Longfei Li,

Yijia Ke

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 372, P. 123632 - 123632

Published: April 10, 2025

Language: Английский

Citations

0
Identification of mitochondrial function and programmed cell death associated key biomarkers and the circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus DOI Creative Commons

Junjie Cao,

Aifang Li, Hui Zhou

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 14, 2025

Objectives Systemic Lupus Erythematosus (SLE) is a highly heterogeneous autoimmune disease with complex pathogenic mechanisms. Mitochondrial function and programmed cell death (PCD) play important roles in SLE. This study aims to screen biomarkers related mitochondrial SLE analyze their underlying Methods SLE-related databases were derived from the GEO database, where three merged into one database as training set. Genes PCD sourced MitoCarta 3.0 database. Key genes identified through bioinformatics machine learning, expression levels diagnostic efficacy validated using two datasets validation The relationship between immune cells was analyzed CIBERSORT infiltration analysis. Diagnostic genes-related miRNAs predicted online databases. Differential circRNAs screened circRNA datasets, circbank, finally constructing circRNA-miRNA-mRNA ceRNA regulatory network. Results From 448 differential set, key genes, IFI27 LAMP3, learning WGCNA. Enrichment analysis revealed that they mainly enriched pathways such cycle, systemic lupus erythematosus, cytosolic DNA sensing pathway, toll-like receptor (TLR) signaling pathway nod-like (NLR) pathway. Immune found compared normal group, 11 differentially expressed, 9 types of LAMP3 10 cells. final constructed network consists 2 mRNAs, 5 miRNAs, 4 circRNAs. Conclusion Our ultimately (IFI27 LAMP3) an role In future, have potential become diagnosis treatment Their response may provide new strategies for

Language: Английский

Citations

0
The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration DOI Creative Commons

Zhaobai Lao,

X. Fang,

Shuchao Shen

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7705 - 7719

Published: Oct. 1, 2024

Systemic lupus erythematosus (SLE) is an autoimmune disorder marked by immune system dysregulation and autoantibodies production, causing widespread inflammation damage across various body systems. Despite the prevalent back pain in SLE patients, link between intervertebral disc (IVD) degeneration, a primary contributor to pain, remains inadequately understood. This study explored impact of on IVD degeneration using MRL/

Language: Английский

Citations

2
Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages DOI

Ziwen Qiu,

Yingtao Zhong, Zhen‐Ming Lu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Treatment‐induced cell pyroptosis can improve the immunogenicity of breast cancer and enhance efficacy immune checkpoint blockade (ICB), but resultant recruitment immunosuppressive cells impedes systemic anti‐tumor immunity. Herein, a rationally designed self‐adaptor (R@L‐MRS17) is developed to initiate concomitantly reeducate pyroptosis‐recruited macrophages ICB therapy. Of which, R@L‐MRS17 promotes cancer‐specific drug delivery through CD47 recognition, enables plasma membrane targeted photosensitizer insertion hydrophobic electrostatic interactions. Under light excitation, produces reactive oxygen species (ROS) in situ trigger pyroptosis, followed by release pro‐inflammatory factors recruit tumor immunogenicity. Moreover, acid responsiveness facilitates R848 polarize infiltrated into M1 phenotype for active Additionally, capable blocking restore recognition phagocytosis behavior M1‐type against cells. In short, stepwise activation significantly suppresses bilateral growth metastasis combination with αPD‐L1. This study provides self‐adaptable strategy activate immunological cascade, which may spatiotemporally amplify responses cancer.

Language: Английский

Citations

0