Applications of plant‐derived extracellular vesicles in medicine DOI Creative Commons

Yawen Zhu,

Junqi Zhao, Haoran Ding

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 20, 2024

Plant-derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the potential plant-derived EVs emphasizes anti-inflammatory, antimicrobial, tumor-inhibitory effects. Here, we discussed advancements in isolation purification techniques, such as ultracentrifugation size-exclusion chromatography, which critical for maintaining functional integrity these nanovesicles. Next, investigated diverse administration routes carefully weighed respective advantages challenges related bioavailability patient compliance. Moreover, elucidated multifaceted mechanisms action EVs, including roles anti-inflammation, antioxidation, antitumor activity, modulation gut microbiota. We also impact on specific diseases cancer inflammatory bowel disease, highlighting importance addressing current production scalability, regulatory compliance, immunogenicity. Finally, proposed future research directions optimizing EV extraction developing targeted delivery systems. Through efforts, envision seamless integration into mainstream medicine, offering safe potent alternatives across various medical disciplines.

Language: Английский

Small extracellular vesicles: crucial mediators for prostate cancer DOI Creative Commons
Sijie Tang,

Huiying Cheng,

Xueyan Zang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 21, 2025

Abstract Small extracellular vesicles (sEVs) play a critical role in the progression, diagnosis, and treatment of prostate cancer (PCa), particularly within tumor microenvironment (TME). Acting as novel biomarkers agents for targeted biological therapy, sEVs contribute significantly to improving patient survival. These transport variety biomolecules, including proteins, nucleic acids, lipids, which are instrumental remodeling TME, facilitating intercellular communication, influencing key processes such growth, metastasis, therapy resistance. A thorough understanding sEV heterogeneity, their biogenesis, characteristics, potential applications, is essential. Recent advances have illuminated origins, formation processes, molecular cargo PCa-derived (PCa-sEVs), enhancing our disease progression. Furthermore, show promise diagnostic markers, with applications early detection prognostic assessment PCa. Therapeutically, natural engineered offer versatile drug delivery, gene immunomodulation, underscoring PCa management. This review delves into substantial clinical practices Graphical

Language: Английский

Citations

0
Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword DOI Creative Commons

Sina Kamrani,

Reza Naseramini,

Pouria Khani

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.

Language: Английский

Citations

0
Influence of the Breast Tumor Stromal Fibroblasts on Immunological Processes In Vitro DOI
R. Yu. Saryglar,

А. Yu. Lupatov,

И. В. Вахрушев

et al.

Bulletin of Experimental Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

Citations

0
Applications of plant‐derived extracellular vesicles in medicine DOI Creative Commons

Yawen Zhu,

Junqi Zhao, Haoran Ding

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 20, 2024

Plant-derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the potential plant-derived EVs emphasizes anti-inflammatory, antimicrobial, tumor-inhibitory effects. Here, we discussed advancements in isolation purification techniques, such as ultracentrifugation size-exclusion chromatography, which critical for maintaining functional integrity these nanovesicles. Next, investigated diverse administration routes carefully weighed respective advantages challenges related bioavailability patient compliance. Moreover, elucidated multifaceted mechanisms action EVs, including roles anti-inflammation, antioxidation, antitumor activity, modulation gut microbiota. We also impact on specific diseases cancer inflammatory bowel disease, highlighting importance addressing current production scalability, regulatory compliance, immunogenicity. Finally, proposed future research directions optimizing EV extraction developing targeted delivery systems. Through efforts, envision seamless integration into mainstream medicine, offering safe potent alternatives across various medical disciplines.

Language: Английский

Citations

1