Carbon quantum dots as ROS-generator and -scavenger: A comprehensive review

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 208, P. 110784 - 110784

Published: Sept. 26, 2022

Language: Английский

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Juglone, a novel activator of ferroptosis, induces cell death in endometrial carcinoma Ishikawa cells

Food & Function, Journal Year: 2021, Volume and Issue: 12(11), P. 4947 - 4959

Published: Jan. 1, 2021

Ferroptosis is a novel iron-dependent cell death pathway mainly caused by an abnormal redox state and associated with various diseases including cancer.

Language: Английский

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Flower‐Like Nanozymes with Large Accessibility of Single Atom Catalysis Sites for ROS Generation Boosted Tumor Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(16)

Published: Dec. 31, 2021

Abstract The use of reactive oxygen species (ROS) generators based on single‐atom catalysts (SACs) has been an emerging strategy for mediating tumor therapy, however, the current systems suffer from low mass transport efficiency. Here, a novel morphology fragmentation is developed to fabricate flower‐like SAC nanozymes with greatly improved 3D accessibility active sites. Specifically, coordinationally polymerized zeolite imidazole framework acts as polyphenol oxidase‐like enzyme catalyze in situ polymerization polydopamine (PDA) which leads blockage micropores and crosslinking morphology‐deteriorated ZIF nanosheets. protective carbonization by PDA results (C‐NFs) plenty reopened defect mesopores (≈4 nm) nanopetals, large interpetal pore space (≈39 nm), high surface area (388 m 2 g −1 ), well ultrahigh loading metal atoms (27.3 wt%). Subsequently, superior peroxidases‐like activity (36.6‐fold increment turnover frequency) facilitates significantly strengthened ROS generation damage biomolecules. Moreover, employment apoferritin modification/loading particle dispersion solution concomitant drug loading. following cancer cell re‐sensitization proven be advantageous boosting ROS‐facilitated treatment drug‐resistant tumors, opening up new avenues therapy.

Language: Английский

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Progress and perspective on hydrogen sulfide donors and their biomedical applications

Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 42(5), P. 1930 - 1977

Published: June 3, 2022

Abstract Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H 2 S) has been identified as third gasotransmitter in humans. Increasing evidence have shown that H S is preventive or therapeutic effects on diverse pathological complications. As a consequence, it great significance to develop suitable approaches S‐based therapeutics for biomedical applications. S‐releasing agents donors) play important roles exploring understanding physiological functions S. More importantly, accumulating studies validated theranostic potential donors extensive repertoires vitro vivo disease models. Thus, imperative summarize update literatures this field. In review, first, background its chemical biological aspects concisely introduced. Second, regarding compounds are categorized described, accordingly, their S‐donating mechanisms, applications, values also comprehensively delineated discussed. Necessary comparisons between related presented, drawbacks many typical analyzed revealed. Finally, several critical challenges encountered development multifunctional discussed, direction future well applications proposed. We expect review will reach audiences across multiple disciplines promote innovation biomedicine.

Language: Английский

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Andrographolide suppresses non-small-cell lung cancer progression through induction of autophagy and antitumor immune response

Pharmacological Research, Journal Year: 2022, Volume and Issue: 179, P. 106198 - 106198

Published: March 31, 2022

Language: Английский

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Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review)

International Journal of Molecular Medicine, Journal Year: 2022, Volume and Issue: 49(5)

Published: March 15, 2022

Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis lead to oxidative stress that may result in cell death. However, tumor microenvironment dynamic responds radiotherapy activating numerous cellular signaling pathways. By scavenging excess ROS, activity endogenous antioxidant enzymes radioresistance worsen clinical outcomes. To assess full potential radiotherapy, it explore underlying mechanisms target identification. The present review article summarized recent data demonstrating nuclear factor‑erythroid factor 2‑related 2 (Nrf2) as a powerful transcription one major defense protect against response radiotherapy; glutathione (GSH) thioredoxin (Trx) systems complement each other are associated with protection cancer cells from damage. In addition, suggested dual targeting inhibit GSH Trx be strategy development radiosensitive radioprotective drugs.

Language: Английский

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Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(9), P. 1515 - 1515

Published: Sept. 15, 2022

Alzheimer's disease (AD) is a neurodegenerative characterized by tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence Aβ-amyloid peptide, protein, oxidative stress, an exacerbated neuro-inflammatory response. This review aims to offer updated compendium most recent promising advances AD treatment through administration phytochemicals. literature survey was carried out electronic search following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, Web Science regarding published works that included molecular mechanisms signaling pathways targeted phytochemicals various experimental models vitro vivo. results studies showed use against has gained relevance due their antioxidant, anti-neuroinflammatory, anti-amyloid, anti-hyperphosphorylation properties protein. Some bioactive compounds from plants have been shown ability prevent stop progression Alzheimer's.

Language: Английский

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The Role of SLC7A11 in Cancer: Friend or Foe?

Cancers, Journal Year: 2022, Volume and Issue: 14(13), P. 3059 - 3059

Published: June 22, 2022

SLC7A11 controls the uptake of extracellular cystine in exchange for glutamate at a ratio 1:1, and it is overexpressed variety tumours. Accumulating evidence has shown that expression fine-tuned multiple levels, plays diverse functional pharmacological roles tumours, such as cellular redox homeostasis, cell growth death, metabolism. Many reports have suggested inhibition activity favourable tumour therapy; thus, regarded potential therapeutic target. However, emerging also suggests on some occasions, beneficial to survival cancer cells, confers development drug resistance. In this review, we first briefly introduce biological properties SLC7A11, including its structure physiological functions, further summarise regulatory network regulators. Then, focusing role cancer, describe relationships with tumourigenesis, survival, proliferation, metastasis, resistance more detail. Finally, since been linked through approaches, propose contribution mechanism require elucidation. Thus, personalised strategies should be adapted when targeting SLC7A11.

Language: Английский

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Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 710 - 710

Published: April 4, 2022

Piperlongumine, a natural alkaloid substance extracted from the fruit of long pepper (Piper longum Linn.), is known to inhibit cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, details mechanism inhibition by piperlongumine against TXNRD1 remain unclear. In this study, based on classical DTNB reducing assay, irreversible recombinant was found showed an apparent kinact value 0.206 × 10−3 µM−1 min−1. Meanwhile, compared with wild-type (-GCUG), UGA-truncated form (-GC) resistant piperlongumine, suggesting preferential target selenol (-SeH) at C-terminal redox motif enzyme. Interestingly, high concentration piperlongumine-inhibited that its Sec-dependent activity decayed but intrinsic NADPH oxidase retained. Furthermore, did not induce ferroptosis in HCT116 cells 10 µM, whereas significantly promoted erastin-induced lipid oxidation, which could be alleviated supplying glutathione (GSH) N-acetyl L-cysteine (NAC). restricting GSH synthesis inhibiting glutaminase (GLS) using small molecule inhibitor CB-839 only slightly enhanced cell death. Taken together, study elucidates molecular antitumor capacity targeting reveals potential possibility strengthen cells’ ferroptosis.

Language: Английский

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An overview on recent advances of reversible fluorescent probes and their biological applications

Talanta, Journal Year: 2023, Volume and Issue: 268, P. 125275 - 125275

Published: Oct. 11, 2023

Language: Английский

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