Synergistic Strategies for Lung Cancer Immunotherapy: Combining Phytochemicals and Immune‐Checkpoint Inhibitors DOI Open Access

Quan Gao,

Hao Wu, Zhengjun Li

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Lung cancer remains one of the most widespread and deadliest malignant tumors globally, with a particularly high mortality rate among all cancers. Recently, immunotherapy, immune checkpoint inhibitors (ICIs), has emerged as crucial treatment strategy for lung patients, following surgical intervention, radiotherapy, chemotherapy, targeted drug therapies. However, therapeutic limitations are caused owing to their low response undesirable side effects such immune‐related pneumonitis. Therefore, developing new strategies improve efficacy ICIs while minimizing adverse events will be immunotherapy. The tumor microenvironment plays significant role in success immunosuppressive characteristics major obstacles poor immunotherapeutic effect. Phytochemicals, naturally occurring compounds plants, have shown promise enhancing immunotherapy by remodeling microenvironment, offering potential increase ICIs. this review summarizes associated mechanisms phytochemicals cancer. Additionally, focus on synergistic combining ICIs, aiming anticancer reduce effects, which may hopefully offer novel overcome current

Language: Английский

Traditional Chinese medicine in lung cancer treatment DOI Creative Commons
Zhichao Xi,

Rongchen Dai,

Yufei Ze

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 26, 2025

Lung cancer remains a major global health challenge and one of the leading causes cancer-related deaths worldwide. Despite significant advancements in treatment, challenges such as drug resistance, side effects, metastasis recurrence continue to impact patient outcomes quality life. In response, there is growing interest complementary integrative approaches care. Traditional Chinese medicine (TCM), with its long history, abundant clinical experience, holistic perspective individualized approach, has garnered increasing attention for role lung prevention management. This review provides comprehensive overview advances TCM covering theoretical foundation, treatment principles, experiences evidence supporting efficacy. We also provide systematic summary preclinical mechanisms, through which impacts cancer, including induction cell death, reversal inhibition modulation immune responses. Additionally, future prospects are discussed, offering insights into expanded application integration modern address this challenging disease.

Language: Английский

Citations

2
Autophagy in tumor immune escape and immunotherapy DOI Creative Commons
Huan Wang, Peng Sun,

Xijing Yuan

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 19, 2025

The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of resistance remains significant. Autophagy, cellular response to various stressors, involves degradation damaged proteins and organelles via lysosomal pathways, maintaining homeostasis. This process not only supports cell survival but also profoundly impacts efficacy cancer immunotherapies. modulation autophagy cells or exerts dual effects on immunotherapy. However, mechanistic details how influences system therapy remain inadequately understood. Given this complexity, deeper understanding role tumor-immune landscape could reveal novel therapeutic avenues. By manipulating appropriately, it may be possible overcome enhance effectiveness immunotherapeutic strategies. article summarizes immunity, its relationship with immunotherapy, potential benefits strengthen antitumor responses optimize outcomes

Language: Английский

Citations

2
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy DOI Open Access
Shutong Li, Aoxue Wang, Yongya Wu

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 300 - 334

Published: Sept. 8, 2023

Summary Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug resistance, is the most common subtype cancer. Therefore, NSCLC patients have very poor prognosis low chance survival. Human cancers are closely linked to regulated cell death (RCD), such as apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis. Currently, small‐molecule compounds targeting various types RCD shown potential anticancer treatments. Moreover, appears be specific part antitumor immune response; hence, combination immunotherapy might increase inhibitory effect therapy on tumor growth. In this review, we summarize used for treatment by focusing pharmacological systems. addition, describe current research status an combined with RCD‐based regimen NSCLC, providing new ideas pathways in future.

Language: Английский

Citations

27
Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer-STAT3 complex nuclear translocation DOI
Yongbo Yu, Ye Liang, Fei Xie

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 593, P. 216964 - 216964

Published: May 16, 2024

Language: Английский

Citations

15
Progress in the Regulation of Immune Cells in the Tumor Microenvironment by Bioactive Compounds of Traditional Chinese Medicine DOI Creative Commons
Yuqian Chen,

Wenshuang Fan,

Yanyan Zhao

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2374 - 2374

Published: May 17, 2024

The tumor microenvironment (TME) can aid cells in evading surveillance and clearance by immune cells, creating an internal environment conducive to cell growth. Consequently, there is a growing focus on researching anti-tumor immunity through the regulation of within TME. Various bioactive compounds traditional Chinese medicine (TCM) are known alter balance modulating activity In turn, this enhances body’s response, thus promoting effective elimination cells. This study aims consolidate recent findings regulatory effects from TCM regulate TME macrophages, dendritic natural killer T lymphocytes their checkpoints. has long history having been used clinical practice China. contains various chemical constituents, including alkaloids, polysaccharides, saponins flavonoids. These components activate thereby improving systemic functions maintaining overall health. review, progress relation derived will be covered, provides basis for further in-depth research development field immunomodulation using TCM.

Language: Английский

Citations

11
Targeting ferroptosis using Chinese herbal compounds to treat respiratory diseases DOI Creative Commons

Mengjiao Xu,

Di Zhang, Jun Yan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155738 - 155738

Published: June 1, 2024

Respiratory diseases pose a grave threat to human life. Therefore, understanding their pathogenesis and therapeutic strategy is important. Ferroptosis novel type of iron-dependent programmed cell death, distinct from apoptosis, necroptosis, autophagy, characterised by iron, reactive oxygen species, lipid peroxide accumulation, as well glutathione (GSH) depletion GSH peroxidase 4 (GPX4) inactivation. A close association between ferroptosis the onset progression respiratory diseases, including chronic obstructive pulmonary disease, acute lung injury, bronchial asthma, fibrosis, cancer, has been reported. Recent studies have shown that traditional Chinese medicine (TCM) compounds exhibit unique advantages in treatment owing natural properties potential efficacy. These can effectively regulate modulating several key signalling pathways such system Xc

Language: Английский

Citations

11
Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies DOI Creative Commons
Fahad Khan, Pratibha Pandey, Meenakshi Verma

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 200 - 200

Published: Feb. 7, 2024

Cancer has become one of the most multifaceted and widespread illnesses affecting human health, causing substantial mortality at an alarming rate. After cardiovascular problems, condition a high occurrence rate ranks second in terms mortality. The development new drugs been facilitated by increased research deeper understanding mechanisms behind emergence advancement disease. Numerous preclinical clinical studies have repeatedly demonstrated protective effects natural terpenoids against range malignancies. potential bioactive investigated sources for their chemopreventive chemoprotective properties. In practically all body cells, signaling molecule referred to as signal transducer activator transcription 3 (STAT3) is widely expressed. that STAT3 regulates its downstream target genes, including Bcl-2, Bcl-xL, cyclin D1, c-Myc, survivin, promote growth differentiation, cell cycle progression, angiogenesis, immune suppression addition chemotherapy resistance. Researchers viewed primary cancer therapy because crucial involvement formation. This primarily focuses on directly indirectly preventing expression tumor cells. By explicitly targeting both vitro vivo settings, it possible explain effect malignant this study, we provide complete overview transduction processes, carcinogenesis, related persistent activation. article also thoroughly summarizes inhibition certain terpenoid phytochemicals, which strong efficacy several models.

Language: Английский

Citations

10
Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy DOI Creative Commons

Peiyi Qin,

Qingchen Li,

Qi Zu

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 2, 2024

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung (NSCLC) being predominant type. The roles autophagy and apoptosis in NSCLC present a dual intricate nature. Additionally, interconnect through diverse crosstalk molecules. Owing to their multitargeting nature, safety, efficacy, natural products have emerged as principal sources for therapeutic candidates. This review begins an exploration mechanisms apoptosis, proceeds examine molecules between these processes, outlines implications interactions NSCLC. Finally, paper reviews that been intensively studied against targeting summarizes detail four most retrieved representative drugs. clarifies good effects by aims promote greater consideration researchers candidates anti-NSCLC drug discovery.

Language: Английский

Citations

9
Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer DOI Creative Commons
Yan Zhi Tan,

Qiancheng Zhu,

Meilin Yang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107314 - 107314

Published: July 24, 2024

The efficacy of PD-1 therapy in non-small cell lung cancer (NSCLC) patients remains unsatisfactory. Activating the STING pathway is a promising strategy to improve inhibitor efficacy. Here, we found tetrandrine (TET), an anti-tumor compound extracted from medicinal plant commonly used traditional Chinese medicine, has ability inhibit NSCLC tumor growth. Mechanistically, TET induces nuclear DNA damage and increases cytosolic dsDNA, thereby activating STING/TBK1/IRF3 pathway, which turn promotes infiltration dendritic cells (DCs), macrophages, as well CD8+ T mice. In vivo imaging dynamically monitored increased activity after treatment predicted activation immune microenvironment. We further revealed that combination with αPD-1 monoclonal antibody (αPD-1 mAb) yields significant anti-cancer effects by promoting enhancing its cell-killing effect, reduced growth tumors prolonged survival Therefore, effectively eliminates enhances immunotherapy through combining anti-PD-1 deserves exploration for applications.

Language: Английский

Citations

9
Impact of targeting the platelet-activating factor and its receptor in cancer treatment DOI Creative Commons

Kimya Qaderi,

Arvin Shahmoradi,

Anita Thyagarajan

et al.

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 4, 2025

Abstract The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological pathophysiological conditions, including cancer growth metastasis. ability PAFR to interact with other oncogenic cascades makes it promising target for treatment. Moreover, numerous natural synthetic compounds, characterized by diverse pharmacological activities such as anti-inflammatory anti-tumor effects, have been explored their potential PAF antagonists. In this review, we provide comprehensive evidence regarding the PAF/PAFR pathway, highlighting effectiveness various classes inhibitors antagonists across multiple models. Notably, synergistic effects enhancing efficacy chemotherapy radiation therapy several experimental models are also discussed. Overall, synthesis literature review indicates that targeting axis represents approach treatment exerts synergy therapy.

Language: Английский

Citations

1