International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15753 - 15753
Published: Dec. 12, 2022
Flavones
are
natural
phytochemicals
broadly
distributed
in
our
diet.
Their
anti-inflammatory
properties
provide
unique
opportunities
to
control
the
innate
immune
system
and
inflammation.
Here,
we
review
role
of
flavones
chronic
inflammation
with
an
emphasis
on
their
impact
molecular
mechanisms
underlying
inflammatory
diseases
including
obesity
cancer.
can
influence
cell
repertoire
restoring
landscape.
impinge
NF-κB,
STAT,
COX-2,
or
NLRP3
inflammasome
pathways
reestablishing
homeostasis.
Devoid
adverse
side
effects,
could
present
alternative
for
treatment
prevention
that
contributes
Critical Reviews in Food Science and Nutrition,
Journal Year:
2021,
Volume and Issue:
63(19), P. 3716 - 3733
Published: Oct. 27, 2021
Obesity
has
become
a
global
health
concern.
It
increases
the
risk
of
several
diseases,
such
as
type
2
diabetes
mellitus,
nonalcoholic
fatty
liver
disease,
and
certain
cancers,
which
threatens
human
social
economic
burden.
As
one
most
consumed
beverages,
tea
contains
various
phytochemicals
with
potent
bioactive
properties
health-promoting
effects,
antioxidant,
immune-regulation,
cardiovascular
protection
anticancer.
Tea
its
components
are
also
considered
potential
candidates
for
anti-obesity.
Epidemiological
studies
indicate
that
regular
consumption
is
beneficial
reducing
body
fat.
In
addition,
experimental
demonstrate
anti-obesity
mechanisms
mainly
involved
in
increasing
energy
expenditure
lipid
catabolism,
decreasing
nutrient
digestion
absorption
well
synthesis,
regulating
adipocytes,
neuroendocrine
system
gut
microbiota.
Moreover,
clinical
illustrate
intake
green
could
reduce
weight
alleviate
obesity.
this
review,
we
focus
on
effect
obesity
from
epidemiological,
experimental,
studies,
discuss
their
mechanisms.
Food & Function,
Journal Year:
2021,
Volume and Issue:
12(19), P. 9300 - 9314
Published: Jan. 1, 2021
In
this
study,
Ougan
juice
(OJ)
and
lactic
acid
bacteria
fermented
(FOJ)
were
investigated
individually
for
their
capability
of
preventing
obesity
in
high-fat
diet
(HFD)-fed
C57BL/6J
mice.
After
being
administered
with
OJ
or
FOJ
10
weeks,
the
body
weight
gain,
hyperlipidemia,
gut
microbiota
dysbiosis
HFD-fed
mice
examined.
The
results
showed
that
supplementation
inhibited
lowered
fat
accumulation,
reduced
liver
steatosis,
improved
glucose
homeostasis
insulin
sensitivity,
increased
brown
adipose
tissue
(BAT)
activity,
promoted
white
(WAT)
browning.
Both
additions
diversity
microbiota.
relative
abundance
phylum
Erysipelatoclostridiaceae
genus
Erysipelatoclostridium
remarkably
SCFA-producing
Blautia,
while
ratio
Firmicutes
to
Bacteroidetes
enhanced
family
Lactobacillaceae.
Spearman's
correlation
analysis
revealed
Akkermansia,
Dubosiella,
Muribaculaceae
significantly
negatively
correlated
obesity-related
indexes.
general,
exhibited
a
better
inhibitory
effect
on
than
OJ,
possible
mechanism
lies
promoting
WAT
browning
increasing
intestinal
probiotics.
This
study
provides
guidance
developing
as
an
obesity-inhibiting
functional
food.
Chemistry of Materials,
Journal Year:
2021,
Volume and Issue:
33(20), P. 8036 - 8051
Published: Oct. 7, 2021
A
critical
challenge
in
the
enrichment
of
active
ingredients
natural
medicines
is
design
adsorbents
with
high
selectivity
and
adsorption
capacity.
Covalent
organic
frameworks
(COFs),
which
have
adjustable
pores
specific
surface
areas,
could
be
effective
as
for
ingredients.
This
study
used
an
environmentally
friendly
deep
eutectic
solvent
(DES)
instead
solvents
reaction
solvent,
high-crystallinity
COF-DES
was
successfully
prepared.
The
fabricated
using
1,3,5-tris(4-aminophenyl)benzene
2,5-dihydroxyterephthalaldehyde
building
blocks
showed
good
dispersibility,
large
area
(444.56
m2·g–1),
suitable
pore
size
(25.9
Å).
Owing
to
its
unique
structure
functional
group
properties,
can
prevent
interferences
from
other
compounds
such
alkaloids,
resulting
outstanding
selective
performance
flavonoids.
Furthermore,
under
optimized
conditions,
effects
on
flavonoids
were
much
better
than
those
macroporous
resins,
indicating
potential
a
adsorbent
Finally,
flavonoid-possessing
rich
medicine,
Abelmoschus
manihot
(Linn.)
Medicus
flower,
sample
application
COF-DES.
results
that
had
selection
capability
actual
samples.
Moreover,
compared
solid-phase
extraction
(SPE)
columns
based
SPE
column
superior
complex
sample,
alternative
resins.
Additionally,
great
commercial
value
flavonoid
columns.
LWT,
Journal Year:
2022,
Volume and Issue:
163, P. 113533 - 113533
Published: May 8, 2022
Deep
eutectic
solvents
(DESs)
have
been
regarded
as
a
substitute
extraction
solvent
for
conventional
organic
reagents
due
to
their
low
toxicity
and
unique
solubility.
In
this
study,
fifteen
choline
chloride-based
DESs
were
prepared
successfully
integrated
with
microwave-assisted
(MAE)
technique
extracting
Hibiscus
manihot
L.
flowers
natural
antioxidants.
The
selected
DES
exhibited
superior
performance
than
those
by
water
60%
ethanol.
After
statistical
optimization
single-factor
experiments,
Taguchi
orthogonal
design
response
surface
methodology,
the
maximal
yields
of
ten
antioxidants
reached
0.880,
0.328,
0.176,
0.243,
5.143,
4.098,
4.852,
0.171,
0.509
0.303
mg/g,
which
was
1.42–1.94
folds
media
methods.
addition,
enriched
recovered
satisfactory
recovery
yield
88.45%–92.02%,
regenerative
could
be
recycled
at
least
four
times.
Overall,
study
established
green,
safe,
high-efficiency
sustainable
alternative
efficiently
bioactive
ingredients
from
plant
matrices.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(4), P. 622 - 622
Published: March 24, 2022
Flavonoids
have
been
reported
to
play
an
essential
role
in
modulating
processes
of
cellular
redox
homeostasis
such
as
scavenging
ROS.
Meanwhile,
they
also
induce
oxidative
stress
that
exerts
potent
antitumor
bioactivity.
However,
the
contradiction
between
these
two
aspects
still
remains
unclear.
In
this
study,
four
typical
flavonoids
were
selected
and
studied.
The
results
showed
low-dose
slightly
promoted
proliferation
breast
cancer
cells
under
normal
growth
via
gradually
reducing
accumulated
products
demonstrated
a
synergistic
effect
with
reductants
NAC
or
VC.
Besides,
significantly
reduced
content
ROS
MDA
induced
by
LPS
Rosup
but
restored
activity
SOD.
high-dose
markedly
triggered
cell
death
evidenced
upregulated
ROS,
downregulated
SOD
could
be
partly
rescued
pretreatment,
which
was
confirmed
antioxidative
gene
expression
levels.
underlying
mechanism
pinpointed
apoptosis,
cycle
arrest,
mitochondrial
superoxide,
impaired
function
decreased
ATP
synthesis.
Transcriptomic
analysis
apigenin
quercetin
uncovered
activated
TNF-α
signaling,
verified
through
detecting
inflammatory
levels
RAW
264.7
macrophages.
Moreover,
we
identified
BRCA1
overexpression
effectively
attenuated
stress,
inflammation
inhibited
synthesis
high
dose
possibly
repairing
DNA
damage,
revealing
indispensable
biological
resisting
damage
stimulation
caused
exogenous
factors.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2231 - 2231
Published: May 8, 2023
Quercetin
is
a
natural
flavonoid
widely
found
in
fruits
and
vegetables.
Recent
studies
have
shown
that
quercetin
mediates
multiple
beneficial
effects
variety
of
organ
damage
diseases,
considered
healthcare
supplement
with
health-promoting
potential.
Male
infertility
major
health
concern,
testicular
from
causes
an
important
etiology.
Previous
has
protective
effect
on
reproductive
function.
This
may
be
related
to
the
antioxidant,
anti-inflammatory,
anti-apoptotic
biological
activities
quercetin.
Therefore,
this
paper
reviews
mechanisms
by
which
exerts
its
pharmacological
activity
role
induced
various
etiologies.
In
addition,
compiles
application
clinical
trials,
demonstrating
practical
regulating
blood
pressure
inhibiting
cellular
senescence
human
patients.
However,
more
in-depth
experimental
trials
are
needed
confirm
true
value
for
prevention
protection
against
injury.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15914 - 15914
Published: Nov. 2, 2023
Nowadays,
more
and
researchers
engage
in
studies
regarding
the
extraction
of
bioactive
compounds
from
natural
sources.
To
this
end,
plenty
have
been
published
on
topic,
with
interest
field
growing
exponentially.
One
major
aim
such
is
to
maximize
yield
and,
simultaneously,
use
procedures
that
adhere
principles
green
chemistry,
as
much
possible.
It
was
not
until
recently
pulsed
electric
(PEF)
technology
has
put
good
achieve
goal.
This
new
technique
exhibits
many
advantages,
compared
other
techniques,
they
successfully
reaped
for
production
extracts
enhanced
concentrations
compounds.
In
advancing
research,
a
understanding
existing
literature
mandatory
develop
advanced
concepts
future.
The
review
provide
thorough
discussion
most
important
applications
PEF
enhancement
polyphenols
fresh
food
products
by-products,
well
discuss
current
limitations
prospects
field.
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
44(2), P. 497 - 538
Published: Aug. 21, 2023
Abstract
Rheumatoid
arthritis
(RA)
is
a
progressive,
chronic,
autoimmune,
inflammatory,
and
systemic
condition
that
primarily
affects
the
synovial
joints
adjacent
tissues,
including
bone,
muscle,
tendons.
The
World
Health
Organization
recognizes
RA
as
one
of
most
prevalent
chronic
inflammatory
diseases.
In
last
decade,
there
was
an
expansion
on
available
therapeutic
options
which
aimed
to
improve
patient's
quality
life.
Despite
extensive
research
emergence
new
approaches
drugs,
are
still
significant
unwanted
side
effects
associated
these
drugs
vast
number
patients
do
not
respond
positively
existing
strategies.
Over
years,
several
references
use
flavonoids
in
quest
for
treatments
have
emerged.
This
review
summarize
literature
about
flavonoids'
major
pathogenic/molecular
targets
their
potential
lead
compounds
development
effective
molecules
treatment.
It
demonstrated
can
modulate
various
players
inflammation,
regulate
immune
cell
function,
decrease
synoviocytes
proliferation
balance
apoptotic
process,
angiogenesis,
stop/prevent
bone
cartilage
degradation,
all
dominant
features
RA.
Although
further
investigation
necessary
determine
effectiveness
humans,
data
from
vitro
vivo
models
suggest
disease‐modifying
anti‐rheumatic
drugs.
highlights
promising
avenue
future
treatment
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(12), P. 7798 - 7817
Published: Jan. 1, 2023
Microorganisms
evolve
resistance
to
antibiotics
as
a
function
of
evolution.
Antibiotics
have
accelerated
bacterial
through
mutations
and
acquired
combination
factors.
