Cellular and Molecular Life Sciences, Journal Year: 2021, Volume and Issue: 79(1)
Published: Dec. 24, 2021
Language: Английский
Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3578 - 3578
Published: Aug. 14, 2023
Sirtuins are a family of proteins with enzymatic activity. There seven mammalian sirtuins (SIRT1-SIRT7) that found in different cellular compartments. They part crucial pathways and regulated by many factors, such as chemicals, environmental stress, phytochemicals. Several vitro vivo studies have presented their involvement anti-inflammatory, antioxidant, antiapoptotic processes. Recent findings imply phytochemicals resveratrol, curcumin, quercetin, fisetin, berberine, kaempferol may regulate the activity sirtuins. Resveratrol mainly activates SIRT1 indirectly AMPK. Curcumin influences SIRT3, but its is broad, cells affected. Quercetin modulates SIRT1, which triggers antioxidant responses. Fisetin, through regulation, modifies lipid metabolism anti-inflammatory Berberine has wide spectrum effects significant impact on signaling pathways. Finally, induction. This review aims to summarize recent properties modulation sirtuin activity, particular focus biochemical aspects.
Language: Английский
Citations
48
Trends in Cell Biology, Journal Year: 2021, Volume and Issue: 31(12), P. 994 - 1006
Published: July 17, 2021
Language: Английский
Citations
67
Clinical Reviews in Allergy & Immunology, Journal Year: 2021, Volume and Issue: 61(3), P. 299 - 323
Published: July 20, 2021
Language: Английский
Citations
63
Aging and Disease, Journal Year: 2023, Volume and Issue: 14(3), P. 794 - 794
Published: Jan. 1, 2023
Sirtuins (SIRT1-SIRT7), a family of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes, are key regulators life span and metabolism. In addition to acting as deacetylates, some sirtuins have the properties deacylase, decrotonylase, adenosine diphosphate (ADP)-ribosyltransferase, lipoamidase, desuccinylase, demalonylase, deglutarylase, demyristolyase. Mitochondrial dysfunction occurs early on acts causally in pathogenesis neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD). implicated regulation mitochondrial quality control, which is highly associated with diseases. There growing evidence indicating that promising well-documented molecular targets for treatment disorders by regulating biogenesis, mitophagy, fission/fusion dynamics, unfolded protein responses (mtUPR). Therefore, elucidation etiology sirtuin-mediated control points new prospects However, mechanisms underlying remain obscure. this review, we update summarize current understanding structure, function, an emphasis cumulative putative effects biology particularly their roles control. addition, outline potential therapeutic applications diseases targeting through exercise training, calorie restriction, sirtuin modulators
Language: Английский
Citations
29
Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 390, P. 110890 - 110890
Published: Jan. 24, 2024
Language: Английский
Citations
11
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(9), P. 104113 - 104113
Published: July 26, 2024
Celiac disease (CeD), an autoimmune disorder triggered by gluten, affects around 1% of the global population. Standard treatment is a strict gluten-free diet (GFD), which poses significant challenges due to dietary restrictions, cross-contamination and subsequent persistent intestinal inflammation. This underscores need for new options addressing complex pathophysiology CeD. Recent research focuses on developing drugs that target barrier regeneration, gluten peptide modification, immune response alteration, gut microbial ecosystem modulation. These approaches offer potential more effective management CeD beyond GFD. Gluten-independent treatments may be particularly relevant under FDA's draft guidance CeD, emphasizes drug development as adjunct GFD patients with ongoing signs symptoms despite
Language: Английский
Citations
10
Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 377 - 377
Published: Jan. 24, 2025
Celiac disease is attributable to a combination of genetic predisposition and exposure dietary gluten, with immune system involvement. The incidence increasing globally, the societal economic burden celiac stretches beyond cost gluten-free food. This enteropathy that affects small intestine has been related different disorders comorbidities. Thus, implications suffering from this are multidimensional need further consideration. serious condition remains under-recognized, resulting in an increased for programs better management. review aims summarize current evidence regarding diseases, special emphasis on clinical implications, diagnosis, management, socioeconomical aspects, future perspectives.
Language: Английский
Citations
2
Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Language: Английский
Citations
2
Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 1, 2025
ABSTRACT Background Cachexia is a wasting syndrome associated with imbalanced energy metabolism and loss of adipose muscle tissues contributes to morbidity mortality in ageing as well patients severe chronic diseases, including cancer. At present, there are no treatments addressing cachexia that have reached validation be used the clinic. In this study, we investigate protective role SIRT6, an important regulator homeostasis health preservation, against Lewis lung carcinoma (LLC)–induced cachexia. Methods SIRT6 levels serum from gastric cancer ( n = 22, 65.27 ± 12.50 years old, 40.9% females) healthy controls 63.50 10.77 45.4% were measured evaluate correlation between circulating development. Ten‐week‐old transgenic (TG) wild type (WT) male mice injected LLC cells (1.5 × 10 6 per mouse) effects on cachexia‐associated browning lipolysis underlying mechanisms. We explored effect LLC‐conditioned medium induced mature adipocytes, differentiated primary mouse embryonic fibroblasts (MEFs). evaluated vitro activator by treatment MDL800. Results concentrations significantly higher non‐cachectic (3.41 0.30 ng/mL) compared cachectic (3.20 0.23 ng/mL, p < 0.01), suggesting negative level overexpression ameliorated tumour‐induced expenditure white (eWAT mass loss: 66% WT vs. 32% TG; iWAT 69% 40% TG) through suppression lipolysis. LLC‐induced cachexia, tumour necrosis factor‐α receptor 2 (TNFR2) mediated inhibition lipolytic signalling, because difference knockout group was almost eliminated TNFR2 neutralizing antibody. Increased concentration found (690.41 pg/mL 1166.98 patients, 0.05). A selective pharmaceutical activator, MDL800, could completely reverse adipocytes. Conclusion unexpected beneficial function demonstrating increased expression or activity capable protecting host tissue wasting, providing concept future therapies for
Language: Английский
Citations
2
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 12(2), P. 876 - 889
Published: July 2, 2021
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological pathological processes. Targeting by allosteric modulators represents a novel direction for therapeutics, which can overcome selectivity problem caused structural similarity of orthosteric sites among deacetylases. Here, developing reversed strategy AlloReverse, we identified cryptic site, Pocket Z, was only induced bi-directional signal triggered upon binding NAD+. Based on discovered an inhibitor named JYQ-42. JYQ-42 selectively targets other histone deacetylases effectively inhibits deacetylation, with IC50 2.33 μmol/L. significantly suppresses SIRT6-mediated cancer cell migration pro-inflammatory cytokine production. JYQ-42, our knowledge, is most potent selective inhibitor. This study provides drug design will help in challenging development therapeutic agents that bind SIRT6.
Language: Английский
Citations
53