Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 15, 2022
The
pathological
condition
of
insulin
resistance
prevents
the
neuroprotective
effects
insulin.
Numerous
studies
have
demonstrated
that
resistance,
as
an
independent
risk
factor
for
ischemic
stroke,
accelerates
formation
thrombosis
and
promotes
development
atherosclerosis,
both
which
are
major
mechanisms
stroke.
Additionally,
negatively
affects
prognosis
patients
with
stroke
regardless
whether
patient
has
diabetes,
but
not
well
studied.
We
explored
association
between
primary
brain
injury
in
(inflammation,
oxidative
stress,
neuronal
damage),
looking
potential
causes
poor
due
to
resistance.
Furthermore,
we
summarize
therapeutic
approaches
propose
new
directions
clinically
improving
Frontiers in Molecular Neuroscience,
Journal Year:
2022,
Volume and Issue:
15
Published: May 6, 2022
Millions
of
patients
are
suffering
from
ischemic
stroke,
it
is
urgent
to
figure
out
the
pathogenesis
cerebral
ischemia-reperfusion
(I/R)
injury
in
order
find
an
effective
cure.
After
I/R
injury,
pro-inflammatory
cytokines
especially
interleukin-1β
(IL-1β)
upregulates
brain
cells,
such
as
microglia
and
neuron.
To
ameliorate
inflammation
after
nucleotide-binding
oligomerization
domain
(NOD),
leucine-rich
repeat
(LRR),
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome
well-investigated.
NLRP3
inflammasomes
complicated
complexes
that
activated
by
endogenous
exogenous
danger
signals
participate
inflammatory
response.
The
assembly
activation
lead
caspase-1-dependent
release
cytokines,
interleukin
(IL)-1β
IL-18.
Furthermore,
pyroptosis
a
cell
death
occurs
dependent
manner
on
injury.
In
this
review,
we
summarized
inflammasome;
moreover,
also
concluded
pivotal
role
inhibitors,
targeting
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 13, 2022
Necroptosis,
a
recently
discovered
programmed
cell
death,
has
been
pathologically
linked
to
various
diseases
and
is
thus
promising
target
for
treating
diseases.
However,
comprehensive
objective
report
on
the
current
status
of
entire
necroptosis
research
lacking.
Therefore,
this
study
aims
conduct
bibliometric
analysis
quantify
identify
quo
trending
issues
in
last
decade.Articles
were
acquired
from
Web
Science
Core
Collection
database.
We
used
two
tools
(CiteSpace
VOSviewer)
individual
impact
cooperation
information
by
analyzing
annual
publications,
journals,
co-cited
countries/regions,
institutions,
authors,
authors.
Afterwards,
we
identified
areas
co-occurrence
burst
keywords
references.From
2012
2021,
total
3,111
articles
published
786
academic
journals
19,687
authors
885
institutions
82
countries/regions.
The
majority
publications
China
United
States,
which
States
maintained
dominant
position
research;
meanwhile,
Chinese
Academy
Sciences
Ghent
University
most
active
institutions.
Peter
Vandenabeele
papers,
while
Alexei
Degterev
had
co-citations.
Cell
Death
&
Disease
papers
necroptosis,
was
top
1
journal,
major
area
these
molecular,
biology,
immunology.
High-frequency
mainly
included
those
that
are
molecularly
related
(MLKL,
TNF-alpha,
NF-κB,
RIPK3,
RIPK1),
pathological
process
(cell-death,
apoptosis,
necrosis,
inflammation),
disease
(cancer,
ischemia/reperfusion
injury,
infection,
carcinoma,
Alzheimer's
disease).Necroptosis
stable
stepwise
growth
past
decade.
Current
studies
focused
its
cross-talk
with
other
types
potential
applications
treatment,
further
mechanisms.
Among
them,
synergy
ferroptosis,
RIPK1/RIPK3/MLKL
studies,
association
inflammation
oxidative
stress
translational
applications,
therapeutic
treat
cancer
neurodegenerative
area.
These
might
provide
ideas
field.
Journal of Inflammation Research,
Journal Year:
2022,
Volume and Issue:
Volume 15, P. 1555 - 1574
Published: March 1, 2022
Ferroptosis
is
a
novel
regulated
cell
death
characterized
by
metabolic
disorders
and
iron-dependent
oxidative
destruction
of
the
lipid
bilayer.
It
primarily
caused
imbalance
oxidation
anti-oxidation
in
body
precisely
numerous
factors
pathways
inside
outside
cell.
Recent
studies
have
indicated
that
ferroptosis
plays
vital
role
pathophysiological
process
multiple
systems
including
nervous
system.
may
be
closely
linked
to
occurrence
development
neurodegenerative
diseases,
strokes,
brain
tumors.
also
involved
development,
maturation,
aging
Therefore,
this
study
aims
investigate
ferroptosis's
regulatory
mechanism
summarize
its
research
progress
pathogenesis
treatment
neurological
diseases.
This
would
allow
for
ideas
basic
clinical
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 15, 2022
The
pathological
condition
of
insulin
resistance
prevents
the
neuroprotective
effects
insulin.
Numerous
studies
have
demonstrated
that
resistance,
as
an
independent
risk
factor
for
ischemic
stroke,
accelerates
formation
thrombosis
and
promotes
development
atherosclerosis,
both
which
are
major
mechanisms
stroke.
Additionally,
negatively
affects
prognosis
patients
with
stroke
regardless
whether
patient
has
diabetes,
but
not
well
studied.
We
explored
association
between
primary
brain
injury
in
(inflammation,
oxidative
stress,
neuronal
damage),
looking
potential
causes
poor
due
to
resistance.
Furthermore,
we
summarize
therapeutic
approaches
propose
new
directions
clinically
improving
