Capsaicin: Emerging Pharmacological and Therapeutic Insights

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 7895 - 7943

Published: July 24, 2024

Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already a number established clinical and industrial applications. Capsaicin is known to act through TRPV1 receptor, which exists various tissues; capsaicin hepatically metabolised, having half-life correlated with method application. Research on applications different formulations still ongoing. Thus, local have pronounced anti-inflammatory effect, while systemic multitude effects because their increased lipophilic character ensures augmented bioavailability. Furthermore, teams documented capsaicin's anti-cancer effects, proven both vivo vitro designs. A notable constraint therapeutic its toxicity, especially sensitive tissues. Regarding capsaicin, apart from all recorded as medicinal application acupuncture points demonstrated be effective combination warrants further research. Finally, antimicrobial can supplement anti-carcinogenic actions.

Language: Английский

---

Capsaicin from chili peppers and its analogues and their valued applications: An updated literature review

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116034 - 116034

Published: Feb. 25, 2025

Language: Английский

---

Comprehensive investigation of niosomal red palm wax gel encapsulating ginger (Zingiber officinale Roscoe): Network pharmacology, molecular docking, In vitro studies and phase 1 clinical trials

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134334 - 134334

Published: July 31, 2024

Language: Английский

---

TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 240, P. 102634 - 102634

Published: June 2, 2024

Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1), also known as capsaicin receptor, in 1997 was a milestone achievement the research on temperature sensation and pain signalling. Very soon after it became evident that TRPV1 is implicated wide array physiological processes different peripheral tissues, well central nervous system, thereby could be involved pathophysiology numerous diseases. Increasing evidence suggests modulation may affect seizure susceptibility epilepsy. This channel localized brain regions associated with seizures epilepsy, its overexpression found both animal models samples from epileptic patients. Moreover, non-neuronal cells (microglia, astrocytes, and/or immune cells) have an impact neuroinflammatory play role epilepsy epileptogenesis. In this paper, we provide comprehensive critical overview currently available data possible molecular target for management, trying to identify gaps future directions. Overall, several converging lines implicate potentially attractive but more studies are needed exploit seizures/epilepsy evaluate value ligands candidates new antiseizure drugs.

Language: Английский

---

Capsaicin preferentially inhibits slow-inactivation sodium currents in insects

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108264 - 108264

Published: Jan. 1, 2025

Language: Английский

---

Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Vascular aging and its associated diseases represent a principal cause of mortality among the global elderly population, making mitigation vascular significant aspiration for humanity. This article explores intersection nature health, focusing on role natural plant, pepper, bioactive compound, capsaicin, in combating aging. By examining molecular cellular mechanisms as well phenotypic alterations blood vessels, we offer comprehensive review effects capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1), within We propose that may serve medication with to slow progress could constitute new strategy treat related disease.

Language: Английский

---

Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119894 - 119894

Published: May 1, 2025

Language: Английский

---

Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4469 - 4469

Published: Oct. 21, 2023

Capsaicin, a lipophilic, volatile compound, is responsible for the pungent properties of chili peppers. In recent years, significant increase in investigations into its has allowed production new formulations and development tools with biotechnological, diagnostic, potential therapeutic applications. Most these studies show beneficial effects, improving antioxidant anti-inflammatory status, inducing thermogenesis, reducing white adipose tissue. Other mechanisms, including food intake intestinal dysbiosis, are also described. this way, possible clinical application such compound expanding every year. This opinion article aims to provide synthesis findings regarding mechanisms by which capsaicin participates control non-communicable diseases as obesity, diabetes, dyslipidemia.

Language: Английский

---

Preparation, pungency, and bioactivity of capsaicin: a review

International Journal of Food Science & Technology, Journal Year: 2024, Volume and Issue: 59(9), P. 6659 - 6687

Published: June 20, 2024

Summary Capsaicin is the main pungent compound in red pepper responsible for its dual attributes of culinary utility and bioactive efficacy. This review aims to systematically preparation methods, pungency, bioactivities capsaicin. can be extracted by maceration, microwave, near‐infrared extraction, supercritical fluid, ultrasound‐assisted extraction methods. Also, it synthesised through chemical, biosynthetic, vitro cell elicit a sensation via activation TRPV1 receptor. Furthermore, has been reported display various bioactivities, such as hypoglycaemic, hypolipidemic, analgesic, anti‐cancer, anti‐inflammatory, intestinal health‐protecting activities several signalling pathways. Overall, this provide theoretical reference understanding preparation, sensation,

Language: Английский

---

Are We Ready to Recommend Capsaicin for Disorders Other than Neuropathic Pain?

Published: Sept. 27, 2023

Capsaicin, a lipophilic, volatile compound, is responsible for the pungent properties of chili peppers. In recent years, significant increase in investigations into its has allowed production new formulations and development tools with biotechnological, diagnostic, potential therapeutic applications. this way, possible clinical application such compound expanding every year. This opinion article aims to provide synthesis findings regarding mechanisms by which capsaicin participates control non-communicable diseases as obesity, diabetes, dyslipidemia. review also discusses studies use body weight control.

Language: Английский

---