New strategies for lung cancer diagnosis and treatment: applications and advances in nanotechnology DOI Creative Commons
Jiaqi Feng,

Pengpeng Zhang,

Dingli Wang

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 13, 2024

Lung cancer leads in causing cancer-related mortality worldwide, continually posing a significant threat to human health. Current imaging diagnostic techniques, while offering non-invasive detection, suffer from issues such as insufficient sensitivity and the risks associated with radiation exposure. Pathological diagnosis, gold standard for confirmation, also faces challenges like invasiveness high costs. In treatment, surgery, radiotherapy, chemotherapy are main modalities, each encountering related precision, environmental adaptability, side effects. Nanotechnology's advancement provides new solutions diagnosis treatment of lung cancer, promising enhance accuracy reduce effects during treatment. This article introduces types nanomaterials used field comprehensive overview current research on application nanotechnology early screening, monitoring summarizing ongoing clinical findings.

Language: Английский

Green and sustainable synthesis of nanomaterials: Recent advancements and limitations DOI
Deepshikha Gupta, Anuj Boora,

Amisha Thakur

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116316 - 116316

Published: June 1, 2023

Language: Английский

Citations

174
Advances of medical nanorobots for future cancer treatments DOI Creative Commons
Xiangyi Kong, Peng Gao, Jing Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: July 14, 2023

Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.

Language: Английский

Citations

103
Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

81
A Hybrid Dependable Deep Feature Extraction and Ensemble-Based Machine Learning Approach for Breast Cancer Detection DOI Creative Commons
Selina Sharmin, Tanvir Ahammad, Md. Alamin Talukder

et al.

IEEE Access, Journal Year: 2023, Volume and Issue: 11, P. 87694 - 87708

Published: Jan. 1, 2023

Breast cancer is a prevalent and life-threatening disease that requires effective detection diagnosis methods to improve patient outcomes. Deep learning (DL) machine (ML) techniques have emerged as powerful tools in breast detection, offering benefits such improved accuracy efficiency. However, existing scalability performance limitations, emphasizing the need for further research. In this paper, we propose hybrid dependable approach combines power of DL using pre-trained ResNet50V2 model ensemble-based ML methods. The integration enables learn extract hidden patterns from complex images, while algorithms contribute interpretability generalization capabilities. We conducted extensive experiments histopathology image-based publicly available Invasive Ductal Carcinoma (IDC) dataset comprising samples different sizes. results obtained our rigorous provide compelling evidence model's robustness high performance. achieved higher rate 95%, precision 94.86%, recall 94.32%, F1 score 94.57% compared state-of-the-art models. also identified Light Boosting Classifier (LGB) most suitable conjunction with architecture. research offer significant contributions through an innovative approach, comprehensive analysis, assessment. Moreover, it has potential assist medical professionals making informed decisions, improving care, enhancing outcomes patients.

Language: Английский

Citations

59
Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy DOI
Zheng Wang,

Shuo Pang,

Xiaoli Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579

Published: May 23, 2024

Language: Английский

Citations

35
Multifunctional Biomimetic Liposomes with Improved Tumor‐Targeting for TNBC Treatment by Combination of Chemotherapy, Anti‐Angiogenesis and Immunotherapy DOI
Jinshuai Lan, Lixia Chen, Zhe Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 20, 2024

Triple negative breast cancer (TNBC) featuring high relapses and metastasis shows limited clinical therapeutic efficiency with chemotherapy for the extremely complex tumor microenvironment, especially angiogenesis immunosuppression. Combination of antiangiogenesis immunotherapy holds promise effective inhibition proliferation invasion, while it remains challenging specific targeting drug delivery to tumors metastatic lesions. Here, a multifunctional biomimetic liposome loading Gambogic acid (G/R-MLP) is developed using Ginsenoside Rg3 (Rg3) substitute cholesterol cell membrane coating, which designed increase long-circulating action by low immunogenicity specifically deliver gambogic (GA) site lesions homologous glucose transporter targeting. After G/R-MLP accumulates in primary nodules, synergistically enhances antitumor efficacy GA, effectively suppressing growth lung killing cells, inhibiting migration achieving improving immunity. All all, strategy combining chemotherapy, antiangiogenesis, improves prolonged survival, providing new perspective treatment TNBC.

Language: Английский

Citations

30
A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects DOI Creative Commons
Samreen Sadiq, Shoaib Khan, Iltaf Khan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25521 - e25521

Published: Feb. 1, 2024

Nanomaterials (NMs) have garnered significant attention in recent decades due to their versatile applications a wide range of fields. Thanks tiny size, enhanced surface modifications, impressive volume-to-surface area ratio, magnetic properties, and customized optical dispersion. NMs experienced an incredible upsurge biomedical including diagnostics, therapeutics, drug delivery. This minireview will focus on notable examples that tackle important issues, demonstrating various aspects such as design, synthesis, morphology, classification, use cutting-edge applications. Furthermore, we classified outlined the distinctive characteristics advanced nanoscale particles hybrid NMs. Meanwhile, emphasize potential metal-organic frameworks (MOFs), highly group These MOFs gained recognition promising candidates for bio-applications, bioimaging, biosensing, antiviral therapy, anticancer nanomedicines, theranostics, immunotherapy, photodynamic photothermal gene Although shown great field, clinical is still limited by issues stability, cytotoxicity, biocompatibility, health concerns. review article provides thorough analysis offering valuable insights researchers investigating explore new development, expansion opportunities. Remarkably, ponder prospects nanocomposites conjunction with current technology.

Language: Английский

Citations

25
BC-QNet: A Quantum-Infused ELM Model for Breast Cancer Diagnosis DOI
Anas Bilal, Azhar Imran, Xiaowen Liu

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 175, P. 108483 - 108483

Published: April 24, 2024

Language: Английский

Citations

25
Recent advances in nanomaterial-based drug delivery systems DOI
Vikram Jadhav, Arpita Roy,

Kirtanjot Kaur

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 37, P. 101103 - 101103

Published: Feb. 1, 2024

Language: Английский

Citations

24
Implantable, 3D-Printed Alginate Scaffolds with Bismuth Sulfide Nanoparticles for the Treatment of Local Breast Cancer via Enhanced Radiotherapy DOI Creative Commons

Busra Colak,

Yavuz Nuri Ertaş

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 15718 - 15729

Published: March 20, 2024

Surgical removal of tumor tissue remains the primary clinical approach for addressing breast cancer; however, complete excision is challenging, and remaining cells can lead to recurrence metastasis over time, which substantially deteriorates life quality patients. With aim improve local cancer radiotherapy, this work reports fabrication alginate (Alg) scaffolds containing bovine serum albumin (BSA)-coated bismuth sulfide (Bi2S3@BSA) nanoradiosensitizers using three-dimensional (3D) printing. Under single-dose X-ray irradiation in vitro, Alg-Bi2S3@BSA significantly increase formation reactive oxygen species, enhance inhibition cells, suppress their colony capacity. In addition, implanted under murine model show high therapeutic efficacy by reducing volume growth rate irradiation, while histological observation main organs reveals no cytotoxicity or side effects. 3D-printed produced with biocompatible biodegradable materials may potentially lower rates patients inhibiting residual following postsurgery as well exhibit anticancer properties other solid tumors.

Language: Английский

Citations

18