ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Language: Английский
Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 993 - 1016
Published: Dec. 2, 2024
Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.
Language: Английский
Citations
34
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 18, 2025
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis
Language: Английский
Citations
2
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24
Published: Jan. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Language: Английский
Citations
2
Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 8, 2024
Applying artificial intelligence (AI) to nanomedicine has greatly increased the production of specially engineered nanoscale materials for tailored medicine, marking a significant advancement in healthcare. With use AI, researchers can search through massive databases and find nano-properties that support range therapeutic objectives, eventually producing safer, customized nanomaterials. AI analyzes patient data, including clinical genetic information, predict results individualized care makes recommendations therapy improvement. Furthermore, logically creates nanocarriers give precise controlled drug release patterns optimize advantages minimize undesirable side effects. Even though lot potential nanomedicine, there are still issues data integration techniques, moral dilemmas, requirement governmental backing. Future developments tools multidisciplinary cooperation between scientists with expertise biological sciences nanoengineering essential nanomedicine. Together, these disciplines propel advancements precision contributing ultimate objective—a future which combine provide really The authors this editorial encourage call on scientists, physicians, legislators acknowledge its transform treatment.
Language: Английский
Citations
12
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Language: Английский
Citations
9
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 8, 2025
Colorectal cancer (CRC) is one of thes most prevalent malignant tumors worldwide. Current therapeutic strategies for CRC have limitations, while nanomaterials show significant potential diagnosing and treating CRC. This study utilizes bibliometric analysis to evaluate the current status trends in this field. Research on from 2003 2024 was retrieved Web Science Core Collection (WOSCC). Tools such as CiteSpace, VOSviewer, RStudio, GraphPad Prism, Excel were used analyze hotspots, covering publication trends, countries, institutions, authors, journals, co-citation analysis, keywords. Visual maps created forecast future developments. The includes 3,683 publications by 17,261 authors 3,721 institutions across 100 countries/regions, published 840 journals. Global steadily increased, particularly since 2018. China leads volume citations, with six top ten research seven cited United States excels citation impact academic centrality. Both countries currently dominate field, underscoring urgent need enhanced international collaboration. Ramezani M Abnous K lead H-index, Siegel RL highly cited. International Journal Nanomedicine has highest volume, Controlled Release In addition "colorectal cancer" "nanoparticles," common keyword "drug delivery." Emerging areas "metal-organic frameworks (MOFs)" "green synthesis" are gaining attention leading hotspots. offers an in-depth application CRC, promoting interdisciplinary collaboration advancing scientific progress
Language: Английский
Citations
1
Fundamental Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 85 - 107
Published: Feb. 5, 2025
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160181 - 160181
Published: Feb. 1, 2025
Language: Английский
Citations
1