Use of adjuvants to improve antibiotic efficacy and reduce the burden of antimicrobial resistance DOI
Teresa Gil‐Gil, Pablo Laborda, José Luis Martínez

et al.

Expert Review of Anti-infective Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

The increase of antibiotic resistance, together with the absence novel antibiotics, makes mandatory introduction strategies to optimize use existing antibiotics. Among them, molecules that their activity looks promising.

Language: Английский

Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review DOI Creative Commons
Mateusz Kciuk, Anjali Garg, Manni Rohilla

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 775 - 775

Published: June 27, 2024

Rheumatoid arthritis (RA) is a persistent autoimmune disorder that characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness often restricted may be linked to unfavorable side effects. Consequently, there has been growing interest in investigating naturally derived compounds as plausible agents for RA disease. The objective this review summarize existing preclinical clinical evidence regarding efficacy extracted plant extracts treatment RA, focusing on anti-inflammatory, anti-oxidative, immunomodulatory properties. Some problems with using natural chemicals are uneven quality commercially available preparations poor bioavailability these compounds. Future investigations should focus improving formulations, conducting thorough trials, exploring different techniques fully utilize intrinsic potential treating RA.

Language: Английский

Citations

7
Dihydroartemisinin inhibits the development of autoimmune thyroiditis by modulating oxidative stress and immune imbalance DOI Creative Commons

Shuangjie Zhu,

Yiping Cui,

Huizheng Hu

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 231, P. 57 - 67

Published: Feb. 21, 2025

Language: Английский

Citations

0
Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer DOI Creative Commons

Laurensia Danis Anggradita,

Joo-Hyun Kim,

Min‐Kyu Kim

et al.

View, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Tongue cancer is a significant threat to human health due its propensity spread throughout the oral cavity and other regions of head neck. The challenges posed by high invasion, metastasis, late clinical detection underscore urgency for effective interventions. In this study, we elucidate promising anti‐cancer properties artemisinin, an anti‐malarial drug, in inhibiting cellular interactions within tongue cell line. Our findings reveal that artemisinin treatment effectively suppresses phosphorylated focal adhesion kinase downstream AKT pathway, thereby enhancing apoptotic processes inducing cycle arrest, consequently impeding proliferation. Moreover, induces rearrangement diminishes cell's capacity generate traction stress, restraining migration on matrix, as determined via force microscopy. Additionally, transition from N‐cadherin E‐cadherin expression occurs at junctions, lowering intracellular measured monolayer stress This significantly curtails migratory capabilities. vivo studies corroborate these findings, showing reduction tumor volume following treatment. study highlights therapeutic potential use novel strategy treatment, which acts modulating both intercellular interactions.

Language: Английский

Citations

0
Magnolol and honokiol: potential lead compounds for the new drug discovery in treating autoimmune diseases DOI Creative Commons
Xian Lin, Jian Chen

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Language: Английский

Citations

0
Dihydroartemisinin alleviates erosive bone destruction by modifying local Treg cells in inflamed joints: A novel role in the treatment of rheumatoid arthritis DOI
Xiaoxue Cao, Zhaoran Wang, Yi Jiao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 130, P. 111795 - 111795

Published: March 1, 2024

Language: Английский

Citations

2
Novel artesunate and isatin hybrid CT3-1 suppresses collagen-induced arthritis through abrogating dendritic cell chemotaxis-induced by CCR5 DOI

Juan He,

Xian Lin,

Xu Gao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112264 - 112264

Published: May 28, 2024

Language: Английский

Citations

2
Advances in the study of artemisinin and its derivatives for the treatment of rheumatic skeletal disorders, autoimmune inflammatory diseases, and autoimmune disorders: a comprehensive review DOI Creative Commons
Zhiyong Long, Xiang Wang, Wei Xiao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 25, 2024

Artemisinin and its derivatives are widely recognized as first-line treatments for malaria worldwide. Recent studies have demonstrated that artemisinin-based antimalarial drugs, such artesunate, dihydroartemisinin, artemether, not only possess excellent properties but also exhibit antitumor, antifungal, immunomodulatory effects. Researchers globally synthesized artemisinin like SM735, SM905, SM934, which offer advantages low toxicity, high bioavailability, potential immunosuppressive properties. These compounds induce immunosuppression by inhibiting the activation of pathogenic T cells, suppressing B cell antibody production, enhancing differentiation regulatory cells. This review summarized mechanisms analogs modulate excessive inflammation immune responses in rheumatic skeletal diseases, autoimmune inflammatory disorders, through pathways including TNF, Toll-like receptors, IL-6, RANKL, MAPK, PI3K/AKT/mTOR, JAK/STAT, NRF2/GPX4. Notably, context NF-κB pathway, inhibits expression disrupting upstream cascades and/or directly binding to downregulates multiple downstream genes controlled NF-κB, chemokines their receptors. targets regulate various functions, apoptosis, proliferation, signal transduction, antioxidant responses, ultimately intervening systemic diseases organs kidneys, nervous system, skin, liver, biliary system modulating dysregulation responses. Ongoing multicenter randomized clinical trials investigating effects these on rheumatic, inflammatory, with aim translating promising preclinical data into applications.

Language: Английский

Citations

2
Antimaláricos como alternativa en el tratamiento de enfermedades autoinmunes DOI Creative Commons
Jhon Bryan Mina Ortiz,

Christian Isaac Castro-Fienco,

Anthony David Guerra-Pincay

et al.

MQRInvestigar, Journal Year: 2024, Volume and Issue: 8(1), P. 5092 - 5117

Published: March 20, 2024

Las enfermedades autoinmunes sistémicas (EAS) han cobrado gran importancia en la medicina los últimos años. Estas se caracterizan por cambios mecanismos de tolerancia inmune, dando lugar a respuestas inmunes anormales debido formación anticuerpos contra estructuras celulares y tejidos. Diseño estudio: La metodología aplicada fue mediante una revisión sistemática literatura. Se usarán las bases datos PubMed, SciELO, Springer, Google Scholar, Elsevier, Dialnet, como fuentes secundarias para encontrar dichos artículos. Estos deberán estar publicados desde el 2019, sin restricción idiomas. Resultado: El medicamento Hidroxicloroquina países Estados unidos (96%), España (82,6%), Colombia (80,6%), resulto ser muy favorable tratar autoinmunes. En actualidad medicamentos hidroxicloroquina, cloroquinas nuevos fármacos Artemisininas está un mejor resultado tratamiento 2023 china obtuvo 83% (Artemisininas) (esclerosis múltiple) comparación del tradicional con 70%. mayor medida presenta trastornos gastrointestinales, oculares, reacciones piel.

Citations

1
The potential efficacy of sesquiterpenes and their derivatives in treating rheumatoid arthritis: A systematic review DOI

Jing Han,

Bingrong Wu,

Dongsheng Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112946 - 112946

Published: Aug. 18, 2024

Language: Английский

Citations

1
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids DOI
Dong Chen, Guangxin Li, Lianxiang Luo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156155 - 156155

Published: Oct. 18, 2024

Language: Английский

Citations

1