Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

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Metal nanoparticles in neuroinflammation: impact on microglial dynamics and CNS function

RSC Advances, Journal Year: 2025, Volume and Issue: 15(7), P. 5426 - 5451

Published: Jan. 1, 2025

Metal NPs cross BBB and release low drug doses in a time-controlled manner the target site. AuNPs IONPs predominantly inhibit neuroinflammation, while other metal promote it. possess dual role modulating microglia.

Language: Английский

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The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep

Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

According to statistics, more than one‐third of the global population currently experiences sleep problems, and about 10% adults have been diagnosed with insomnia, a proportion that is increasing annually. Most used insomnia medications are not specifically developed but discovered by chance, often resulting in unavoidable side effects like addiction. Thus, there an urgent need find safer effective therapeutic options. Resveratrol, natural polyphenolic compound, shows significant potential improving insomnia. Research its may be achieved through multiple biological processes, including antiapoptosis, antioxidant activity, anti‐inflammation, circadian rhythm regulation, modulation neurotransmitters (gamma‐aminobutyric acid (GABA), DA, 5‐HT, cortisol), increased levels neurotrophic factor BDNF. Additionally, resveratrol’s treatment closely linked SIRT1, AMPK, NF‐ κ B, mTOR, PI3K/Akt, MAPK pathways. This review summarizes mechanisms resveratrol treating provide researchers deeper understanding action, which can aid development novel targeted drugs offer innovative ideas methods for clinical treatment.

Language: Английский

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Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 189 - 214

Published: April 10, 2025

Language: Английский

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Nanocarrier-based targeted drug delivery for Alzheimer’s disease: addressing neuroinflammation and enhancing clinical translation

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-beta (Aβ) aggregation, tau pathology, and chronic neuroinflammation. Among these, neuroinflammation plays crucial role in exacerbating progression, making it an attractive therapeutic target. However, the presence of blood-brain barrier (BBB) significantly limits effective delivery agents to brain, necessitating novel drug strategies. Nanocarrier-based systems have emerged as promising solution these challenges, offering targeted transport, enhanced BBB penetration, improved bioavailability while minimizing systemic toxicity. This review explores current advancements nanocarrier-mediated for AD, focusing on mechanisms neuroinflammation, nanocarriers overcoming BBB, their ability modulate inflammatory pathways. Furthermore, discusses preclinical validation strategies key including safety concerns, large-scale production limitations, regulatory hurdles that must be addressed enable clinical translation. Future perspectives emphasize integration nanotechnology with precision medicine, gene therapy, artificial intelligence optimize nanocarrier design individualized AD treatment. By obstacles, hold potential revolutionize approaches other diseases.

Language: Английский

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The NF-κB Pathway: Key Players in neurocognitive functions and related disorders

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 984, P. 177038 - 177038

Published: Oct. 5, 2024

Language: Английский

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Resveratrol’s bibliometric and visual analysis from 2014 to 2023

Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Introduction Resveratrol (RSV) is a natural polyphenolic compound derived from variety of plants that possesses wide range biological activities, including antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, anti-aging, anti-radiation damage, anti-apoptosis, immune modulation, regulation glucolipid metabolism, inhibition lipid deposition, and anti-neuro. It therefore considered promising drug with the potential to treat diseases. Method In this study, using Web Science Core Collection (WoSCC) CiteSpace bibliometric tool, VOSviewer quantitatively visualized number countries, authors, institutions, publications, keywords, references 16,934 resveratrol-related papers 2014–2023 for quantitative qualitative analysis. Results The results showed an average 1693.4 were published per year, general upward trend. China had most publications 5877. Medical University was institution largest highest citations in field. research team mainly led by Prof. Richard Tristan, journal Molecular. Dietary polyphenols, oxidative stress, antioxidant anti-inflammatory effects are frequently cited articles. Oxidative apoptosis, expression, other keywords play important role connecting branches Discussion Our analysis indicates integration nanoparticles RSV poised become significant markedly inhibits harmful bacteria, fosters proliferation beneficial enhances diversity intestinal flora, thereby preventing flora dysbiosis. Additionally, exhibits both antibacterial antiviral properties. also promotes osteogenesis serves neuroprotective function models Alzheimer's disease. applications medicine healthcare vast. A future challenge lies modifying its structure develop derivatives superior activity bioavailability. coming years, innovative pharmaceutical formulations RSV, oral, injectable, topical preparations, may be developed enhance bioavailability therapeutic efficacy.

Language: Английский

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Lactoferrin-modified nanoemulsions enhance brain-targeting and therapeutic efficacy of arctigenin against Toxoplasma gondii-induced neuronal injury

International Journal for Parasitology Drugs and Drug Resistance, Journal Year: 2024, Volume and Issue: 27, P. 100575 - 100575

Published: Dec. 20, 2024

Language: Английский

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