Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC‐1α/SIRT3 Pathway to Prevent Western Diet‐Induced Obesity

Molecular Nutrition & Food Research, Journal Year: 2023, Volume and Issue: 67(18)

Published: July 23, 2023

Sirtuin 1/peroxisome proliferator-activated receptor gamma co-activator 1 alpha (SIRT1/PGC-1α) pathway activation is known to promote thermogenesis and mitochondrial biogenesis. Pterostilbene (PSB) pinostilbene (PIN), the methylated analogs of resveratrol, are potential candidates enhance biogenesis.A model Western diet-induced obesity in mice designed. Either PSB or PIN supplemented diet for 16 weeks. Both samples can significantly reduce body weight gain but only decrease inguinal adipose tissue weight. Besides, both lipolysis supplementation activates SIRT1/PGC-1α/SIRT3 biogenesis tissue. In addition, although exert a modulatory effect on gut microbiota significant increments fecal isobutyric acid, valeric isovaleric acid observed group, functioning as microbial metabolites.Overall, these findings suggest improvement dysbiosis. With its higher stability, exerts greater than by promoting via SIRT1 activation.

Language: Английский

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Certain Fermented Foods and Their Possible Health Effects with a Focus on Bioactive Compounds and Microorganisms

Fermentation, Journal Year: 2023, Volume and Issue: 9(11), P. 923 - 923

Published: Oct. 24, 2023

Fermented foods refer to beverages or made by carefully regulated microbial growth and the enzymatic conversion of dietary components. have recently become more popular. Studies on fermented suggest types bacteria bioactive peptides involved in this process, revealing linkages that may impacts human health. By identifying studies relationships impressions been associated with obesity, cardiovascular disease, type 2 diabetes. In article, dairy products, vegetables fruits, legumes, meats, grains are included. Two elements particular emphasized when discussing fermentation all these foods: chemicals generated during microorganisms fermentation. Organic acids, peptides, conjugated linoleic acid, biogenic amines, isoflavones, phytoestrogens, nattokinase a few compounds included review. Also, certain such as Lactobacillus, Bifidobacterium, Streptococcus, Bacillus species, which utilized process mentioned. The effects both substances including anti-fungal antioxidant properties; modulation intestinal microbiota; anti-inflammatory, antidiabetes, anti-obesity, anticancer, antihypertension protection cognitive function explained

Language: Английский

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Exploring the Geroprotective Potential of Nutraceuticals

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2835 - 2835

Published: Aug. 24, 2024

Aging is the result of accumulation a wide variety molecular and cellular damages over time, meaning that “the more damage we accumulate, higher possibility to develop age-related diseases”. Therefore, reduce incidence such diseases improve human health, it becomes important find ways combat damage. In this sense, geroprotectors have been suggested as molecules could slow down or prevent diseases. On other hand, nutraceuticals are another set compounds align with need promote health since they biologically active (occurring naturally in food) that, apart from having nutritional role, preventive properties, antioxidant, anti-inflammatory antitumoral, just mention few. present review using specialized databases Scopus PubMed collected information articles published 2010 2023 order describe role during aging process and, given their targeting hallmarks aging, suggest potential be consumed part our regular diet administered additionally supplements.

Language: Английский

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Identification of Indicative Gut Microbial Guilds in a Natural Aging Mouse Model

ACS Omega, Journal Year: 2023, Volume and Issue: 8(39), P. 36569 - 36580

Published: Sept. 21, 2023

Gut microbial dysbiosis during later life may contribute to health conditions, possibly due an increase in intestinal permeability, immune changes, and systemic inflammation. Mouse models have been employed determine the influence of gut microbes on aging; however, suitable indicators are currently lacking. Therefore, this study aimed their potential guilds a natural aging mouse model. In agreement with previous studies, alpha diversity indices-including observed OTUs, ACE, Chao1, Simpson-were significantly lower aged mice than younger mice. The results beta analysis revealed compositional differences between young mice, MRPP, ANOSIM, Adonis tests indicated that were representative. By employing ANCOM LEfSe analyses, Bacteroides thetaiotaomicron (Bacteroides) Anaeroplasma identified as respectively. Notably, these still present after 3 months. result network confirmed negative correlation genera guild members based increased abundance tend correspond those involved human diseases, selenocompound metabolism, glycolysis/gluconeogenesis functional predictions. study, identified, it is envisaged findings could provide new approach for future studies antiaging.

Language: Английский

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Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep

Toxics, Journal Year: 2023, Volume and Issue: 12(1), P. 15 - 15

Published: Dec. 23, 2023

Prenatal exposure to endocrine disruptors such as bisphenol A (BPA) plays a critical role in the developmental programming of liver dysfunction that is characteristic nonalcoholic fatty disease (NAFLD). Circadian and aging processes have been implicated pathogenesis NAFLD. We hypothesized prenatal BPA-induced fatty-liver phenotype female sheep associated with premature hepatic senescence disruption circadian clock genes. The expression rhythm aging-associated genes, along other markers telomere length, mitochondrial DNA copy number, lipofuscin accumulation, were evaluated tissue control BPA groups. significantly elevated genes GLB1 CISD2 induced large magnitude differences genes—APOE, HGF, KLOTHO, PER2 CLOCK—in liver; remained unaffected. BPA-programmed aging-related transcriptional changes may contribute pathological function, elucidating involvement steatosis.

Language: Английский

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Exploring the functional roles of sustainable dietary patterns on gut microbiota composition and optimal health

Bioactive Compounds in Health and Disease - Online ISSN 2574-0334 Print ISSN 2769-2426, Journal Year: 2024, Volume and Issue: 7(2), P. 110 - 130

Published: Feb. 22, 2024

The aging population presents a growing global challenge, due to increased risk of age-related diseases, leading arising burden on healthcare systems and highlighting the need for effective interventions promote healthy aging. Emerging evidence suggests that certain dietary patterns can influence gut microbiome favorably, potentially mitigating chronic diseases metabolic dysfunction such as diabetes, obesity, cardiovascular diseases. Gut microbiota dynamics, initially stable in early life, are disrupted with age, impacting both prokaryotic eukaryotic symbionts, resulting an adaptive response defined by increase composition diversity over time. In addition environmental genetic factors, impact diet has been noted critical factor influences these dynamics. this review, we propose sustainable like Mediterranean, vegetarian, ketogenic, DASH diets suitable panacea counteract deleterious feeding offering nutritious environmentally options, lowering prevalence further explores their functional roles respect modulating composition, overall optimal health. Keywords: Aging; diet; microbiota; Mediterranean Diet; Plant-based intervention

Language: Английский

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Effect of Triadica cochinchinensis honey supplementation on liver metabolomics and gut microbiota in naturally aging mice

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104863 - 104863

Published: Aug. 3, 2024

Language: Английский

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