Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway DOI Creative Commons
Xueqing Duan, You-Qi Nie, Xin Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via

Language: Английский

Regulation of bile acids and their receptor FXR in metabolic diseases DOI Creative Commons
Yao Li, Lulu Wang, Yi Qing

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 11, 2024

High sugar, high-fat diets and unhealthy lifestyles have led to an epidemic of obesity obesity-related metabolic diseases, seriously placing a huge burden on socio-economic development. A deeper understanding elucidation the specific molecular biological mechanisms underlying onset development has become key treatment diseases. Recent studies shown that changes bile acid composition are closely linked Bile acids can not only emulsify lipids in intestine promote lipid absorption, but also act as signaling molecules play indispensable role regulating homeostasis, energy expenditure, glucose metabolism, immunity. Disorders metabolism therefore important risk factors for The farnesol X receptor, member nuclear receptor family, is abundantly expressed liver intestinal tissues. endogenous ligands erroneous FXR triggered by dysregulation contributes including obesity, non-alcoholic fatty disease diabetes. Activation reduce lipogenesis inhibit gluconeogenesis alleviate It been found regulate hepatic organ-wide manner. crosstalk between provides new idea This review focuses relationship diseases current research progress provide theoretical basis further clinical applications.

Language: Английский

Citations

7
Degraded sweet corn cob polysaccharides modulate T2DM-induced abnormalities in hepatic lipid metabolism via the bile acid-related FXR-SHP and FXR-FGF15-FGFR4 pathways DOI

Weiye Xiu,

Xin Wang,

Zhiguo Na

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105085 - 105085

Published: Sept. 10, 2024

Language: Английский

Citations

5
Role of Intestinal Microbiome in Potentiating Inflammation and Predicting Outcomes in Alcohol-associated Cirrhosis DOI
Sidsel Støy, Bernd Schnabl

Gastroenterology Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury DOI
Chen Liu, Yi Wang, Linlin Sheng

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156445 - 156445

Published: Feb. 2, 2025

Language: Английский

Citations

0
High-throughput screening of probiotics in fermented foods and their potential application in alleviating alcohol-induced damage. DOI

J.-F. Zhang,

Mingliang Li,

Dongliang Ren

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Probiotics screening in fermented foods for alcohol damage mitigation.

Language: Английский

Citations

0
Impact of Lactocaseibacillus (Lactobacillus) paracasei sup. paracasei TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial DOI Open Access

Kamonsri Nuankham,

Jaruwan Sitdhipol, Pennapa Chonpathompikunlert

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2916 - 2916

Published: Sept. 1, 2024

Probiotics have shown potential in managing hypercholesterolemia and related metabolic conditions. This study evaluated the effects of Lactocaseibacillus (Lactobacillus) paracasei sup. TISTR 2593 on gut microbiome health patients with hypercholesterolemia, was registered Thai Clinical Trial Registry (TCTR 20220917002). In a randomized, double-blind, placebo-controlled trial, 22 hypercholesterolemic participants received either probiotic or placebo daily for 90 days. Fecal samples collected before after intervention revealed significant changes, including decrease Subdoligranulum, linked to rheumatoid arthritis, an increase Flavonifractor, known its anti-inflammatory properties. Additionally, group exhibited reduction low-density lipoprotein cholesterol (LDL-C) levels. These findings suggest that L. can modulate improve health, warranting further investigation into mechanisms long-term benefits.

Language: Английский

Citations

3
Flavonoids from Rhododendron nivale Hook. f ameliorate alcohol-associated liver disease via activating the PPARα signaling pathway DOI
Xiao Guo, Chen Liu, Zhen Dong

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156215 - 156215

Published: Nov. 8, 2024

Language: Английский

Citations

1
Sex differences and testosterone interfere with the structure of the gut microbiota through the bile acid signaling pathway DOI Creative Commons
Xueqing Duan, You-Qi Nie, Xin Xie

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 18, 2024

Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via

Language: Английский

Citations

0