Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 275 - 275

Published: Jan. 13, 2025

Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is worldwide health problem due to the alarming rise in prevalence and elevated morbidity mortality. Chronic hyperglycemia, insulin resistance, ineffective effect secretion are hallmarks of T2DM, leading many secondary complications. These include, particular, cardiovascular disorders, diabetic neuropathy, nephropathy retinopathy, foot, osteoporosis, liver damage, susceptibility infections some cancers. Polyphenols such as flavonoids, phenolic acids, stilbenes, tannins, lignans constitute an extensive heterogeneous group phytochemicals fresh fruits, vegetables their products. Various vitro studies, animal model studies available clinical trials revealed that flavonoids (e.g., quercetin, kaempferol, rutin, epicatechin, genistein, daidzein, anthocyanins), acids chlorogenic, caffeic, ellagic, gallic curcumin), stilbenes resveratrol), tannins procyanidin B2, seaweed phlorotannins), pinoresinol) have ability lower enhance sensitivity improve secretion, scavenge reactive oxygen species, reduce chronic inflammation, modulate gut microbiota, alleviate complications T2DM. The interaction between polyphenols conventional antidiabetic drugs offers promising strategy management treatment especially advanced disease stages. Synergistic effects with been documented, but also antagonistic interactions may impair drug efficacy. Therefore, additional research required clarify mutual order use knowledge applications. Nevertheless, dietary can be successfully applied part supportive for they both obvious symptoms

Language: Английский

Polyphenol extracts from rambutan peel promote longevity via the attenuation of the Toll/Imd pathway

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Rambutan peel polyphenols effectively improve the lifespan and health of Drosophila . It may exert life-extending effect through preservation balanced redox status gut barrier integrity, as well attenuation Toll/Imd pathway.

Language: Английский