International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(3), P. 906 - 906
Published: Jan. 30, 2020
The
gut
microbiota
remains
relatively
stable
during
adulthood;
however,
certain
intrinsic
and
environmental
factors
can
lead
to
dysbiosis.
Its
restoration
towards
a
healthy
condition
using
best-suited
prebiotics
requires
previous
development
of
in
vitro
models
for
evaluating
their
functionality.
Herein,
we
carried
out
fecal
cultures
with
from
normal-weight
morbid
obese
adults.
Cultures
were
supplemented
different
inulin-type
fructans
(1-kestose,
Actilight,
P95,
Synergy1
Inulin)
galactooligosaccharide.
Their
impact
on
the
was
assessed
by
monitoring
gas
production
changes
composition
(qPCR
16S
rRNA
gene
profiling)
metabolic
activity
(gas
chromatography).
Additionally,
effect
bifidobacterial
species
(ITS-sequencing).
Moreover,
functionality
before
after
prebiotic-modulation
determined
an
model
interaction
intestinal
cell
line.
In
general,
1-kestose
compound
showing
largest
effects.
modulation
led
significant
increases
Bacteroides
group
Faecalibacterium
subjects,
whereas
individuals,
substantial
rises
Bifidobacterium
appreciated.
Notably,
results
obtained
showed
differences
responses
among
tested
compounds
but
also
studied
human
populations,
indicating
need
developing
population-specific
products.
Chinese Medical Journal,
Journal Year:
2023,
Volume and Issue:
136(19), P. 2269 - 2284
Published: July 5, 2023
Abstract
Cardiovascular
diseases,
including
heart
failure,
coronary
artery
disease,
atherosclerosis,
aneurysm,
thrombosis,
and
hypertension,
are
a
great
economic
burden
threat
to
human
health
the
major
cause
of
death
worldwide.
Recently,
researchers
have
begun
appreciate
role
microbial
ecosystems
within
body
in
contributing
metabolic
cardiovascular
disorders.
Accumulating
evidence
has
demonstrated
that
gut
microbiota
is
closely
associated
with
occurrence
development
diseases.
The
functions
as
an
endocrine
organ
secretes
bioactive
metabolites
participate
maintenance
homeostasis,
their
dysfunction
can
directly
influence
progression
disease.
This
review
summarizes
current
literature
demonstrating
We
also
highlight
mechanism
by
which
well-documented
microbiota-derived
metabolites,
especially
trimethylamine
N-oxide,
short-chain
fatty
acids,
phenylacetylglutamine,
promote
or
inhibit
pathogenesis
discuss
therapeutic
potential
altering
improve
prevent
Carbohydrate Polymers,
Journal Year:
2024,
Volume and Issue:
332, P. 121918 - 121918
Published: Feb. 6, 2024
Vegetables,
cereals
and
fruit
are
foods
rich
in
fibre
with
beneficial
nutritional
effects
as
their
consumption
reduces
the
onset
of
degenerative
diseases,
especially
cardiovascular
ones.
Among
fibres,
inulin,
oligofructose
or
fructooligosaccharide
(FOS)
best-studied.
Inulin
is
a
generic
term
to
cover
all
linear
β(2-1)
fructans,
variable
degree
polymerization.
In
this
review
better
understanding
importance
polymerization
inulin
dietary
fibre,
functions,
health
benefits,
classifications,
types
its
applications
food
industry
was
considered
different
fortified
foods.
has
been
used
increase
healthy
properties
product
sweetener
substitute
for
fats
carbohydrates,
improving
value
decreasing
glycemic
index,
advantage
not
compromising
taste
consistency
product.
Bifidogenic
prebiotic
have
well
established,
inulin-type
fructans
fermented
by
colon
produce
short-chain
fatty
acids,
important
local
systemic
actions.
Addition
degrees
daily
production
pasta
bread
reviewed,
impact
on
sensorial,
technological
organoleptic
characteristics
even
gluten-free
also
reported.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(6), P. 2993 - 2993
Published: March 15, 2021
Interaction
between
the
gut
and
brain
is
essential
for
energy
homeostasis.
In
obesity,
this
homeostasis
disrupted,
leading
to
a
positive
balance
weight
gain.
Obesity
global
epidemic
that
affects
individual
health
strains
socioeconomic
system.
Microbial
dysbiosis
has
long
been
reported
in
obesity
obesity-related
disorders.
More
recent
literature
focused
on
interaction
of
microbiota
its
metabolites
human
behavior.
Developing
strategies
target
could
be
future
approach
treatment
obesity.
Here,
we
review
microbiota–gut–brain
axis
possible
therapeutic
options.
mSystems,
Journal Year:
2024,
Volume and Issue:
9(4)
Published: March 5, 2024
The
microbial
utilization
of
dietary
carbohydrates
is
closely
linked
to
the
pivotal
role
gut
microbiome
in
human
health.
Inherent
modulation
complex
communities,
a
prebiotic
implies
selective
specific
substrate,
relying
on
metabolic
capacities
targeted
microbes.
In
this
study,
we
investigated
17
commensal
bacteria
toward
with
potential.
First,
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(23), P. 9239 - 9239
Published: Dec. 3, 2020
Breast
cancer
is
the
most
frequently
diagnosed
in
women
worldwide.
The
disease
and
its
treatments
exert
profound
effects
on
an
individual’s
physical
mental
health.
There
are
many
factors
that
impact
risk
of
developing
breast
cancer,
their
response
to
treatments,
recurrence.
community
microorganisms
inhabiting
gastrointestinal
tract,
gut
microbiota,
affects
human
health
through
metabolic,
neural,
endocrine
signaling,
immune
activity.
It
these
mechanisms
microbiota
appears
influence
risk,
treatment,
A
disrupted
or
state
‘dysbiosis’
can
contribute
a
biological
environment
associated
with
higher
for
development
as
well
negative
treatment
side-effects.
Many
have
been
shown
shift
toward
dysbiosis;
however,
also
be
positively
manipulated
diet,
prebiotic
probiotic
supplementation,
exercise.
objective
this
review
provide
overview
current
understanding
relationship
between
highlight
potential
strategies
modulation
could
lead
improved
clinical
outcomes
overall
population.
Annual Review of Food Science and Technology,
Journal Year:
2020,
Volume and Issue:
11(1), P. 205 - 233
Published: Jan. 17, 2020
Obesity
is
a
major
public
health
concern
that
has
almost
reached
the
level
of
pandemic
and
rapidly
progressing.
The
gut
microbiota
emerged
as
crucial
regulator
involved
in
etiology
obesity,
manipulation
it
by
dietary
intervention
been
widely
used
for
reducing
risk
obesity.
Nondigestible
oligosaccharides
(NDOs)
are
attracting
increasing
interests
prebiotics,
indigestible
ingredients
can
induce
compositional
or
metabolic
improvement
to
microbiota,
thereby
improving
giving
rise
production
short-chain
fatty
acids
(SCFAs)
elicit
effects
on
In
this
review,
role
NDOs
play
obesity
via
modification
microecology,
well
physicochemical
physiological
properties
industrial
manufacture
NDOs,
discussed.
Our
goal
provide
critical
assessment
stimulate
comprehensive
research
into
NDO
use
