Gut Microbiota Dysbiosis in Celiac Disease, Exploring the Probiotic Solution DOI Creative Commons

Hadeer Mohammed Ali,

Z Mohammed,

Oruba Khalid Abbas

et al.

Iraqi Journal of Community Medicine, Journal Year: 2025, Volume and Issue: 38(2), P. 96 - 102

Published: March 31, 2025

Abstract The gut microbiome significantly influences human health and disease, especially autoimmune disorders. During illness, the microbiota (GM) composition changes (dysbiosis), leading to disrupted communication between immune cells microbiota, which can cause infections activate Gut bacteria are isolated from their host by a physical barrier, such as epithelium lining or skin. Bacterial components lipopolysaccharides bacterial antigens may stimulate an inflammatory response activating stimulating cells. Numerous variables influence intestinal including diet, age, geographical location, mode of delivery, antibiotic probiotic consumption, various medical conditions. Celiac disease (CD) is immune-mediated enteropathy that exhibits gluten sensitivity induces upon consumption. Children with CD typically exhibit abdominal distension, diarrhea, failure thrive. Extraintestinal signs include anemia, tiredness, arthritis, infertility, liver failure, neuropathy, schizophrenia, autism. This review provides potential explanation GMs role in CD.

Language: Английский

Estrogens and the risk of breast cancer: A narrative review of literature DOI Creative Commons
Khayry Al‐Shami, Sajeda Awadi, Almu’atasim Khamees

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e20224 - e20224

Published: Sept. 1, 2023

In female mammals, the development and regulation of reproductive system non-reproductive are significantly influenced by estrogens (oestrogens). addition, lipid metabolism is another physiological role estrogens. Estrogens act through different types receptors to introduce signals target cell affecting many estrogen response elements. Breast cancer considered mostly a hormone-dependent disease. Approximately 70% breast cancers express progesterone and/or receptors, they good marker for prognosis. This review will discuss interaction metabolites with cancer. The carcinogenic discussed in light both conventional atypical susceptible hormones, such as prostate, endometrial, lung cancer, we examine how contributes formation activation this other factors that can be associated estrogen-driven

Language: Английский

Citations

53
Obesity and breast cancer DOI

Dara Bakar,

Raman Mehrzad

Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 83 - 113

Published: Sept. 30, 2022

Language: Английский

Citations

65
Role of Gut Microbiota Dysbiosis in Breast Cancer and Novel Approaches in Prevention, Diagnosis, and Treatment DOI Open Access

Sheila W Ruo,

Tasnim Alkayyali,

Myat Thu Thu Win

et al.

Cureus, Journal Year: 2021, Volume and Issue: unknown

Published: Aug. 26, 2021

Breast cancer is the most common cause of cancer-related deaths in women. still a major morbidity and mortality among women despite all available diagnostic treatment modalities. The gut microbiota has drawn keen interest as an additional environmental risk factor breast cancer, especially sporadic cases. This article explores factors that disrupt normal microbial composition role dysbiosis development cancer. We finalized 40 relevant articles after searching Pubmed Google Scholar using regular keywords Medical Subject Headings (MeSH) strategy. Gut been shown to play via estrogen-dependent mechanisms non-estrogen-dependent involving production microbial-derived metabolites, immune regulation, effects on DNA. influence estrogen metabolism hence levels. metabolites have demonstrated anticancer properties include lithocholic acid, butyrate, cadaverine. New approaches targeting come up may yield new advances prevention, diagnosis, They use prebiotics, probiotics, hormone supplements restore normobiosis prevention

Language: Английский

Citations

64
Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions DOI Creative Commons
Mikhail Syromyatnikov, Ekaterina Nesterova,

Maria Gladkikh

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(9), P. 1866 - 1866

Published: Sept. 18, 2022

High-throughput sequencing has made it possible to extensively study the human gut microbiota. The links between microbiome and ethnicity, religion, race remain rather poorly understood. In this review, data on relationship microbiota composition nationality of people their religion were generalized. unique a healthy European (including Slavic nationality) is characterized by dominance phyla Firmicutes, Bacteroidota, Actinobacteria, Proteobacteria, Fusobacteria, Verrucomicrobia. Among African population, typical members are Bacteroides Prevotella. Asians very diverse rich in genera Prevotella, Lactobacillus, Faecalibacterium, Ruminococcus, Subdoligranulum, Coprococcus, Collinsella, Megasphaera, Bifidobacterium, Phascolarctobacterium. Buddhists Muslims, Prevotella enterotype characteristic microbiome, while other representatives religions, including Christians, have enterotype. Most likely, different nationalities religions influenced food preferences. review also considers influences pathologies such as obesity, Crohn’s disease, cancer, diabetes, etc., bacterial guts nationalities.

Language: Английский

Citations

48
The gut microbiota in breast cancer development and treatment: The good, the bad, and the useful! DOI Creative Commons
Deeptashree Nandi, Sheetal Parida, Dipali Sharma

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: June 12, 2023

Regardless of the global progress in early diagnosis and novel therapeutic regimens, breast carcinoma poses a devastating threat, advances are somewhat marred by high mortality rates. Breast cancer risk prediction models based on known factors extremely useful, but large number cancers develop women with no/low risk. The gut microbiome exerts profound impact host health physiology has emerged as pivotal frontier pathogenesis. Progress metagenomic analysis enabled identification specific changes microbial signature. In this review, we discuss metabolomic associated initiation metastatic progression. We summarize bidirectional various cancer-related therapies microbiota vice-versa. Finally, strategies to modulate toward more favorable state that confers anticancer effects.

Language: Английский

Citations

38
Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review DOI Open Access
Celia García‐Chico, Susana López‐Ortiz, Saúl Peñín‐Grandes

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(1), P. 324 - 324

Published: Jan. 3, 2023

Growing evidence suggests that, among the different molecular/cellular pathophysiological mechanisms associated with cancer, there are 14 hallmarks that play a major role, including: (i) sustaining proliferative signaling, (ii) evading growth suppressors, (iii) activating invasion and metastasis, (iv) enabling replicative immortality, (v) inducing angiogenesis, (vi) resisting cell death, (vii) reprogramming energy metabolism, (viii) immune destruction, (ix) genome instability mutations, (x) tumor-promoting inflammation, (xi) unlocking phenotypic plasticity, (xii) nonmutational epigenetic reprogramming, (xiii) polymorphic microbiomes, (xiv) senescent cells. These also development of breast which represents most prevalent tumor type in world. The present narrative review aims to describe, for first time, effects physical activity/exercise on these hallmarks. In summary, an active lifestyle, particularly regular exercise, provides beneficial all might therefore help counteract progression disease or its burden.

Language: Английский

Citations

32
The Emerging Role of the Microbiota in Breast Cancer Progression DOI Creative Commons
Giancarla Bernardo, Valentino Le Noci, Martina Di Modica

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(15), P. 1945 - 1945

Published: July 27, 2023

Emerging evidence suggests a profound association between the microbiota composition in gastrointestinal tract and breast cancer progression. The gut plays crucial role modulating immune response, releasing metabolites, estrogen levels, all of which have implications for growth. However, recent research has unveiled novel aspect relationship cancer, focusing on microbes residing within mammary tissue, was once considered sterile. These localized microbial communities been found to change presence tumor as compared healthy unraveling their potential contribution Studies identified specific bacterial species that are enriched tumors highlighted mechanisms by even these influence progression through modulation, direct carcinogenic activity, effects cellular pathways involved cell proliferation or apoptosis. This review aims provide an overview current knowledge crosstalk gut/mammary cancer. Understanding this intricate interplay holds promise developing innovative therapeutic approaches.

Language: Английский

Citations

28
The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy DOI Creative Commons

Mostafa A. Madkour,

Rawan A. Altaf, Zeinab S. Sayed

et al.

Advanced Gut & Microbiome Research, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Gut microbiota substantially impacts pathogenic and normal immune responses is associated with common chronic diseases. Moreover, it has a considerable effect on the efficacy of cancer therapy. Variant gut linked checkpoint inhibitors, chemo drugs, radiotherapy resistance. Therefore, comprehensive interpretation interactions between therapies required to encourage researchers develop new prevention strategies weaken consequences different therapies. This review discusses modulating role that focuses its influence each treatment method, in addition delivering an overview microbiota’s forming relationships bacteria, inflammation, Highlighting mechanism action probiotics, antibiotics, fecal transplantation, prebiotics promotes therapies’ efficacy. Consequently, this makes essential as adjunct augmenting therapeutic response.

Language: Английский

Citations

10
Metabolic dysfunction-associated steatotic liver disease: A sexually dimorphic disease and breast and gynecological cancer DOI
Xinrong Zhang,

Mindie H. Nguyen

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156190 - 156190

Published: March 1, 2025

Language: Английский

Citations

1
Nano-Based Theranostic Platforms for Breast Cancer: A Review of Latest Advancements DOI Creative Commons
Rabia Arshad,

Maria Hassan Kiani,

Abbas Rahdar

et al.

Bioengineering, Journal Year: 2022, Volume and Issue: 9(7), P. 320 - 320

Published: July 15, 2022

Breast cancer (BC) is a highly metastatic multifactorial disease with various histological and molecular subtypes. Due to recent advancements, the mortality rate in BC has improved over past five decades. Detection treatment of many cancers are now possible due application nanomedicine clinical practice. Nanomedicine products such as Doxil® Abraxane® have already been extensively used for adjuvant therapy favorable outcomes. However, these were designed initially generic anticancer purposes not specifically treatment. With better understanding biology BC, several novel promising nanotherapeutic strategies devices developed years. In this context, multi-functionalized nanostructures becoming potential carriers enhanced chemotherapy patients. To design nanostructures, wide range materials, proteins, lipids, polymers, hybrid can be tailored specific against BC. Selective targeting cells results activation programmed cell death considered strategy managing triple-negative Currently, conventional screening methods mammography, digital breast tomosynthesis (DBT), ultrasonography, magnetic resonance imaging (MRI) either costly or expose user hazardous radiation that could harm them. Therefore, there need analytical techniques detecting selective sensitive, very low detection limit, durable, biocompatible, reproducible. biomarkers, alone conjunction numerous molecules. This review intends highlight advances diagnosis, emphasizing overexpress receptors epidermal growth factors. Researchers may gain insight from develop more achieve further improvements specificity, antitumorigenic effects, anti-metastasis drug resistance reversal effects.

Language: Английский

Citations

36