Global burden of cardiovascular diseases: projections from 2025 to 2050

European Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Abstract Aims The prediction of future trends in cardiovascular disease (CVD) mortality and their risk factors can assist policy-makers healthcare planning. This study aims to project geospatial CVDs underlying from 2025 2050. Methods results Using historical data on disability-adjusted life years (DALYs) the Global Burden Disease (GBD) 2019 study, encompassing period 1990 2019, Poisson regression was performed model DALYs associated with CVD its Subgroup analysis based GBD super-regions. Between 2050, a 90.0% increase prevalence, 73.4% crude mortality, 54.7% are projected, an expected 35.6 million deaths 2050 (from 20.5 2025). However, age-standardized prevalence will be relatively constant (−3.6%), decreasing (−30.5%) (−29.6%). In ischaemic heart remain leading cause (20 deaths) while high systolic blood pressure main factor driving (18.9 deaths). Central Europe, Eastern Asia super-region is set incur highest rate (305 per 100 000 population). Conclusion coming decades, global suggests that net effect summative preventative efforts likely continue unchanged. fall reflects improvement medical care following diagnosis. systems expect rapid rise driven by ageing populace. continued burden largely attributed atherosclerotic diseases. Registration Not applicable.

Language: Английский

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Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Circulation Cardiovascular Imaging, Journal Year: 2023, Volume and Issue: 16(5)

Published: May 1, 2023

Epicardial adipose tissue (EAT) has garnered attention as a prognostic and risk stratification factor for cardiovascular disease. This study, via meta-analyses, evaluates the associations between EAT outcomes stratified across imaging modalities, ethnic groups, study protocols.Medline Embase databases were searched without date restriction on May 2022 articles that examined outcomes. The inclusion criteria (1) studies measuring of adult patients at baseline (2) reporting follow-up data interest. primary outcome was major adverse events. Secondary included cardiac death, myocardial infarction, coronary revascularization, atrial fibrillation.Twenty-nine published 2012 2022, comprising 19 709 patients, in our analysis. Increased thickness volume associated with higher risks death (odds ratio, 2.53 [95% CI, 1.17-5.44]; P=0.020; n=4), infarction 2.63 1.39-4.96]; P=0.003; n=5), revascularization 2.99 1.64-5.44]; P<0.001; fibrillation (adjusted odds 4.04 3.06-5.32]; n=3). For 1 unit increment continuous measure EAT, computed tomography volumetric quantification hazard 1.74 1.42-2.13]; P<0.001) echocardiographic 1.20 1.09-1.32]; conferred an increased events.The utility biomarker predicting prognosticating disease is promising, being identified independent predictors events.URL: https://www.crd.york.ac.uk/prospero; Unique identifier: CRD42022338075.

Language: Английский

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The burden of cardiovascular disease in Asia from 2025 to 2050: a forecast analysis for East Asia, South Asia, South-East Asia, Central Asia, and high-income Asia Pacific regions

The Lancet Regional Health - Western Pacific, Journal Year: 2024, Volume and Issue: 49, P. 101138 - 101138

Published: July 10, 2024

Given the rapidly growing burden of cardiovascular disease (CVD) in Asia, this study forecasts CVD and associated risk factors Asia from 2025 to 2050.

Language: Английский

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Type 2 diabetes mellitus and cardiometabolic outcomes in metabolic dysfunction-associated steatotic liver disease population

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 211, P. 111652 - 111652

Published: April 2, 2024

Language: Английский

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A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Emerging evidence has demonstrated the unfavourable cardiovascular risk of individuals with lean type 2 diabetes mellitus (T2DM). Our study aims to investigate prognostic value T2DM in patients acute myocardial infarction (AMI), stratified by sex. The cohort examines clinical characteristics and long-term outcomes AMI, four phenotypes based on body category—lean T2DM, non-lean non-T2DM non-T2DM. primary outcome was all-cause mortality. Cox regression model constructed associations mortality, adjusted for age, ethnicity, previous AMI type, chronic kidney disease, angiotensin converting enzyme inhibitor or receptor blockers, beta-blockers, smoking status. A 9545 examined, a mean follow-up duration 3.4 ± 2.4 years. Majority had phenotype (40.4%), followed (29.8%), (15.9%), (13.9%). In group, one-quarter (N = 1324), while vast majority (74.5%) non-lean. Individuals tended be female older. Patients highest rates heart failure (23.3%, p < 0.001), cardiogenic shock (9.1%, 0.036), mortality (32.6%, 0.001). that an independent predictor (adjusted hazard ratio [aHR] 1.171, 95% CI 1.040–1.319, 0.009) after adjustment. presence higher following present males (aHR 1.201, 1.037–1.391, 0.015), but not females 1.066, 0.869–1.308, 0.538). T2DM. although this association stronger than females.

Language: Английский

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Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort

The Lancet Regional Health - Western Pacific, Journal Year: 2023, Volume and Issue: 37, P. 100803 - 100803

Published: May 31, 2023

Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary healthcare policymaking. We estimated future projections incidence diseases in a multi-ethnic population with AMI.The and mortality contributed by AMI (diabetes mellitus [T2DM], hypertension, hyperlipidemia, overweight/obesity, active/previous smokers) were projected up to year 2050, using linear Poisson regression models based on Singapore Myocardial Infarction Registry from 2007 2018. Forecast analysis was stratified age, sex ethnicity.From 2025 predicted rise 194.4% 482 1418 per 100,000 population. The largest percentage increase within be overweight/obesity (880.0% increase), followed hypertension (248.7% T2DM (215.7% hyperlipidemia (205.0% smoking (164.8% increase). number AMI-related deaths expected 294.7% individuals while decrease 11.7% 29.9% 32.7% 49.6% smokers, 2050. Compared Chinese individuals, Indian Malay bear disproportionate burden mortality.The continue rising coming decades. Overweight/obesity will emerge as fastest-growing factor leading mortality.This research supported NUHS Seed Fund (NUHSRO/2022/058/RO5+6/Seed-Mar/03) National Medical Research Council Training Fellowship (MOH-001131). SMIR national, ministry-funded registry run Diseases Office funded Ministry Health, Singapore.

Language: Английский

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Anthropometric and cardiometabolic effects of polyphenols in people with overweight and obesity: an umbrella review

Nutrition Reviews, Journal Year: 2024, Volume and Issue: 82(11), P. 1556 - 1593

Published: Jan. 12, 2024

Abstract Context Polyphenols are plant-based compounds with potential anti-inflammatory, antioxidant, and anti-obesogenic properties. However, their effects on health outcomes remain unclear. Objective To evaluate the of polyphenols anthropometric cardiometabolic markers. Data Sources Six electronic databases—namely, EMBASE, CINAHL, PubMed, Scopus, The Cochrane Library (reviews only), Web Science—were searched for relevant systematic reviews meta-analyses (SRMAs). Extraction Three reviewers performed data extraction via a data-extraction Microsoft Excel spreadsheet. Analysis An umbrella review meta-analysis existing SRMAs was conducted. Eighteen published from 2015 to 2023, representing 445 primary studies 838 unique effect sizes, were identified. Meta-analyses conducted using random-effects models general inverse variance. Polyphenol-containing foods found significantly improve weight (-0.36 kg; 95% confidence interval [CI]: −0.62, 0.77 P &lt; 0.01, I2 = 64.9%), body mass index (−0.25 kg/m2; CI: −0.34, −0.17 0.001, 82.4%), waist circumference (−0.74 cm; −1.34, −0.15 99.3%), low-density-lipoprotein cholesterol (−1.75 mg/dL; −2.56, −0.94; 98.6%), total (−1.23 −2.00, −0.46; 0.002, 94.6%), systolic blood pressure (−1.77 mmHg; −1.77, −0.93 72.4%), diastolic (−1.45 −2.09, −0.80 61.0%), fat percentage (−0.70%; −1.03, −0.36%; 52.6%), fasting glucose (−0.18 −0.35, −0.01 0.04, 62.0%), C-reactive protein (CRP; including high-sensitivity-CRP [hs-CRP]) (−0.2972 −0.52, −0.08 87.9%). No significant changes high-density-lipoprotein (−0.12 −1.44, 0.69; 0.67, 89.4%) triglycerides (−1.29 −2.74, 0.16; 0.08, 85.4%). Between-study heterogeneity could be explained by polyphenol subclass differences. Conclusion findings this support beneficial metabolic markers, but discretion is warranted determine clinical significance magnitude biomarker improvements. Systematic Review Registration International Prospective Register Reviews no. CRD42023420206.

Language: Английский

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Higher risk of adverse cardiovascular outcomes in females with type 2 diabetes Mellitus: an Umbrella review of systematic reviews

European Journal of Preventive Cardiology, Journal Year: 2023, Volume and Issue: 30(12), P. 1227 - 1235

Published: April 26, 2023

Previous studies have shown that females with type 2 diabetes mellitus (T2DM) may excess mortality risk compared to their male counterparts. An important next step address the high global burden of T2DM and cardiovascular disease (CVD) is an umbrella review summarize data on sex differences in outcomes for patients assess strength evidence observed.

Language: Английский

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Effects of probiotics, prebiotics and synbiotics on anthropometric, cardiometabolic and inflammatory markers: An umbrella review of meta-analyses

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1563 - 1583

Published: May 10, 2024

Language: Английский

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Obesity and its management in primary care setting

Journal of Diabetes and its Complications, Journal Year: 2025, Volume and Issue: 39(7), P. 109045 - 109045

Published: April 19, 2025

Language: Английский

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