‘Exerkines’: A Comprehensive Term for the Factors Produced in Response to Exercise DOI Creative Commons
Giuseppe Novelli,

Giuseppe Calcaterra,

Federico Casciani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1975 - 1975

Published: Sept. 1, 2024

Regular exercise and physical activity are now considered lifestyle factors with positive effects on human health. Physical reduces disease burden, protects against the onset of pathologies, improves clinical course disease. Unlike pharmacological therapies, mediated by not limited to a specific target organ but act in multiple biological systems simultaneously. Despite substantial health benefits training, precise molecular signaling processes that lead structural functional tissue adaptation remain largely unknown. Only recently, several bioactive molecules have been discovered produced following exercise. These collectively called “exerkines”. Exerkines released from various tissues response exercise, play crucial role mediating beneficial body. Major discoveries involving exerkines highlight their diverse functions implications, particularly metabolic regulation, neuroprotection, muscle adaptation. molecules, including peptides, nucleic acids, lipids, microRNAs, through paracrine, endocrine, autocrine pathways exert organs tissues. represent complex network mediate Their roles importance maintaining preventing

Language: Английский

Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy DOI Creative Commons
Xi Lu,

Qingxing Xie,

Xiaohui Pan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 2, 2024

Language: Английский

Citations

47
Association between daily movement behaviors and optimal physical fitness of university students: a compositional data analysis DOI Creative Commons
Jiayu Li,

Zu‐Chun Lin,

Minjing Zou

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 5, 2025

This study investigates the relationship between movement behaviors and physical fitness (PF) in university students, based on top 5% of model-predicted outcomes for PF to determine optimal balance. A total 463 students aged 15-24 years from Jinhua City wore accelerometers measure moderate-to-vigorous activity (MVPA), light-intensity (LPA), sedentary behavior (SB). Sleep (SLP) was self-reported. The body mass index (BMI), forced vital capacity (FVC), 50-meter dash, standing long jump, sit-and-reach, sit-ups (female), pull-ups (male), 800-meter run 1000-meter (male) were used as indicators assess students. Regression analysis examine PF. All possible component combinations investigated best correlation (top 5%) with each outcome. For males, SB (β = 5.05, p < 0.05) significantly correlated an increase BMI. MVPA improvements BMI -1.75, 0.05), FVC 494.21, endurance qualities -25.77, 0.05). females, -1.03, 176.05, speed capability -0.26, -16.38, LPA associated -24.10, a decline 24.25, average (range) combination time use follows: 142 min/day, 534 295 SLP 469 min/day. 115 536 306 482 both males increased reduced improved strength, while sleep duration contributed overall fitness. These findings highlight importance balanced daily schedule

Language: Английский

Citations

1
The triglyceride–glucose index is a promising predictor for the risk of cardiovascular disease in the diabetic population aged ≥60 years in the United States: a retrospective cohort study from NHANES (2007-2016) DOI Creative Commons
Shu Yang, Zhenwei Wang

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

The predictive value of triglyceride-glucose index (TyG) for cardiovascular disease (CVD) in the US elderly diabetic patients is ambiguous. This study aimed to investigate association between TyG and risk CVD an older population with diabetes. examined data from 2007-2016 National Health Nutrition Examination Survey (NHANES). Univariate multivariate regression analysis models were obtained explore baseline CVD. Non-linear investigated using restricted cubic spline (RCS) regression. Subgroup analyses interaction tests constructed a sensitivity was carried out. 10 - year evaluated via Framingham Risk Score (FRS). Mediation explored mediating role glycated hemoglobin above relationships. A total 2987 subjects included (977 2010 non-CVD persons). had higher values (9.01 ± 0.58 vs. 8.94 0.56, P=0.003), prevalence increased (P=0.015). In multifactorial model gradual adjustment all covariates, associated by 48.0% highest quartile group (OR 1.480, 95% Cl 1.171-1.871, P=0.001). RCS curves showed U-shaped (P overall=0.013, P nonlinear=0.043). that group, individuals body mass (BMI) ≥24 kg/m2, estimated glomerular filtration rate (eGFR) <90 mL/1.73m2/min, without chronic kidney disease, those hypertension significantly risks Sensitivity indicated these associations not other significant confounders. Under different models, exhibited correlations (all < 0.05). Glycated mediated sample patients, there risk. implies can be regarded as extremely important predictor screening people at high among patients.

Language: Английский

Citations

0
Using Metabolic Testing to Personalize Behavioral Obesity Treatment DOI Creative Commons
Leonard H. Epstein, John W. Apolzan,

Molly Moore

et al.

Obesity Science & Practice, Journal Year: 2025, Volume and Issue: 11(2)

Published: March 11, 2025

ABSTRACT Background There are large individual differences in weight loss and maintenance. Metabolic testing can provide phenotypical information that be used to personalize treatment so people remain negative energy balance during Behavioral assess the reinforcing value change temporal window related personalized diet exercise program motivate maintain engagement healthier eating activity programs. Objective Provide an expository overview of how metabolic control. Ideas about incorporating behavioral economic concepts also included. Methods A broad resting rate, thermic effect food respiratory quotient improve Also discussed principles maximize adherence protocols. Results Research suggests measuring rate set calorie goals for maintenance, increase expenditure, guide macronutrient composition fat loss. Developing programs foster a strong motivation eat active success. Conclusion Incorporating measures programs, use probability long‐term success

Language: Английский

Citations

0
Advances in Exercise and Nutrition as Therapy in Diabetes DOI
Dessi P. Zaharieva,

Dorsa Shakeri,

Lauren V. Turner

et al.

Diabetes Technology & Therapeutics, Journal Year: 2025, Volume and Issue: 27(S1), P. S126 - S140

Published: March 1, 2025

Language: Английский

Citations

0
‘Exerkines’: A Comprehensive Term for the Factors Produced in Response to Exercise DOI Creative Commons
Giuseppe Novelli,

Giuseppe Calcaterra,

Federico Casciani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1975 - 1975

Published: Sept. 1, 2024

Regular exercise and physical activity are now considered lifestyle factors with positive effects on human health. Physical reduces disease burden, protects against the onset of pathologies, improves clinical course disease. Unlike pharmacological therapies, mediated by not limited to a specific target organ but act in multiple biological systems simultaneously. Despite substantial health benefits training, precise molecular signaling processes that lead structural functional tissue adaptation remain largely unknown. Only recently, several bioactive molecules have been discovered produced following exercise. These collectively called “exerkines”. Exerkines released from various tissues response exercise, play crucial role mediating beneficial body. Major discoveries involving exerkines highlight their diverse functions implications, particularly metabolic regulation, neuroprotection, muscle adaptation. molecules, including peptides, nucleic acids, lipids, microRNAs, through paracrine, endocrine, autocrine pathways exert organs tissues. represent complex network mediate Their roles importance maintaining preventing

Language: Английский

Citations

2